Results 91 to 100 of about 507,315 (208)

Coumarin‐Benzimidazole Hybrids as Multitarget Scaffolds for Antileishmanial Drug Discovery

ChemistrySelect, Volume 11, Issue 38, 13 October 2026.
Coumarin‐benzimidazole hybrids emerge as promising antileishmanial agents through virtual screening against essential Leishmania enzymes, Cathepsin B (CatB), and N‐myristoyltransferase (NMT). Molecular docking and dynamics simulations reveal highly stable target interactions that surpass the reference drug miltefosine (MTF).
Fernanda Melo Jucá, Damião Sampaio de Sousa, Caio Henrique Alexandre Roberto, Márcia Machado Marinho, Emmanuel Silva Marinho   +4 more
wiley   +1 more source

Identification of potent inhibitors of the chicken soluble epoxide hydrolase [PDF]

, 2015
In vertebrates, soluble epoxide hydrolase (sEH) hydrolyzes natural epoxy-fatty acids (EpFAs), which are chemical mediators modulating inflammation, pain, and angiogenesis.
Harris, Todd R, Hammock, Bruce D, Lee, Kin Sing S, Yang, Jun, Merzlikin, Oleg, Shihadih, Diyala S, Morisseau, Christophe   +6 more
core   +1 more source

Soluble Epoxide Hydrolase as a Therapeutic Target for Neuropsychiatric Disorders

, 2022
It has been found that soluble epoxide hydrolase (sEH; encoded by the EPHX2 gene) in the metabolism of polyunsaturated fatty acids (PUFAs) plays a key role in inflammation, which, in turn, plays a part in the pathogenesis of neuropsychiatric disorders ...
Shan, Jiajing, Hashimoto, Kenji, Kenji Hashimoto, Jiajing Shan   +3 more
core   +1 more source

Naturally occurring monoepoxides of eicosapentaenoic acid and docosahexaenoic acid are bioactive antihyperalgesic lipids[S]

Journal of Lipid Research, 2010
Beneficial physiological effects of long-chain n-3 polyunsaturated fatty acids are widely accepted but the mechanism(s) by which these fatty acids act remains unclear.
Christophe Morisseau, Bora Inceoglu, Kara Schmelzer, Hsing-Ju Tsai, Steven L. Jinks, Christine M. Hegedus, Bruce D. Hammock   +6 more
doaj   +1 more source

β‐Catenin‐Deficient Intervertebral Disc Cells Reduce Chemotactic Transcription and Myeloid Cell Recruitment to Injured Discs of Mice

Aging Cell, Volume 25, Issue 10, October 2026.
(Left) In young discs, Wnt signaling‐replete nucleus pulposus cells secrete ECM components and, upon disc injury, cytokines to recruit myeloid cells. (Right) Whereas, β‐catenin‐deficient disc cells, modeling age‐related absence of Wnt signaling, exhibit reduced anabolic activity and, upon disc injury, secrete fewer pro‐inflammatory cytokines and ...
Tori M. Kroon, Jazz Munitz, Anna Ranzenigo, Martin Umali, William Wang, Jonathan J. Huang, Abraham J. P. Teunissen, Nilsson Holguin   +7 more
wiley   +1 more source

Theoretical study of the full reaction mechanism of human soluble epoxide hydrolase

, 2006
The complete reaction mechanism of soluble epoxide hydrolase (sEH) has been investigated by using the B3LYP density functional theory method. Epoxide hydrolases catalyze the conversion of epoxides to their corresponding vicinal diols.
Himo, Fahmi,, Hopmann, Kathrin H.,
core   +1 more source

Chromosomal mapping and expression levels of a mouse soluble epoxide hydrolase gene.

, 1994
The chromosomal location of a murine soluble epoxide hydrolase gene was determined using in situ mapping, restriction fragment length polymorphism (RFLP) and simple sequence length polymorphism (SSLP) analysis. In situ hybridization to mouse metaphase
Hammock, B D, Storms, D H, Taylor, B A, Adler, D A, Edelhoff, S, Disteche, C M, Spearow, J L, Grant, D F   +7 more
core   +1 more source

Genetic deletion of soluble epoxide hydrolase delays the progression of Alzheimer’s disease

Journal of Neuroinflammation, 2019
Background Soluble epoxide hydrolase (sEH) is a bifunctional enzyme with COOH-terminal hydrolase and NH2-terminal lipid phosphatase activities. It is expressed in various cell types in the brain and is involved in the pathogenesis of inflammatory and ...
Hsueh-Te Lee, Kuan-I Lee, Chia-Hui Chen, Tzong-Shyuan Lee   +3 more
doaj   +1 more source

Pharmaceutical Effects of Inhibiting the Soluble Epoxide Hydrolase in Canine Osteoarthritis

Frontiers in Pharmacology, 2019
Osteoarthritis (OA) is a degenerative joint disease that causes pain and bone deterioration driven by an increase in prostaglandins (PGs) and inflammatory cytokines.
Cindy B. McReynolds, Cindy B. McReynolds, Sung Hee Hwang, Sung Hee Hwang, Jun Yang, Jun Yang, Debin Wan, Karen Wagner, Karen Wagner, Christophe Morisseau, Dongyang Li, William K. Schmidt, Bruce D. Hammock, Bruce D. Hammock   +13 more
doaj   +1 more source

Soluble Epoxide Hydrolase Inhibitory Activity of Selaginellin Derivatives from Selaginella tamariscina

Molecules, 2015
Selaginellin derivatives 1–3 isolated from Selaginella tamariscina were evaluated for their inhibition of soluble epoxide hydrolase (sEH) to demonstrate their potential for the treatment of cardiovascular disease.
Jang Hoon Kim, Chong Woon Cho, Bui Huu Tai, Seo Young Yang, Gug-seoun Choi, Jong Seong Kang, Young Ho Kim   +6 more
doaj   +1 more source