Results 91 to 100 of about 7,307 (207)
Clinical and Translational Science, Volume 19, Issue 7, July 2026.This study employed an integrated multi‐omics screening strategy incorporating GEO database differential expression analysis, GWAS‐eQTL genetic association analysis, and single‐cell RNA‐seq cell subpopulation localization to identify EPHX2 as a core causal gene in ulcerative colitis (UC).
Tian Dai +8 more
wiley +1 more source
Supplementary information Novel Soluble Epoxide Hydrolase Inhibitor: Toward Regulatory Preclinical Studies [PDF]
Neuroinflammation is widely recognized as a key pathological hallmark of Alzheimer’s disease (AD). Recently, inhibiting soluble epoxide hydrolase (sEH) has emerged as a promising therapeutic strategy for AD.
Sanfeliu, Coral +9 more
core +1 more source
The Plant Journal, Volume 127, Issue 1, July 2026.SUMMARY The Capsicum genus shows remarkable phenotypic diversity, making it an excellent system to study non‐climacteric fruit ripening. Unlike climacteric model species, such as tomato (Solanum lycopersicum), the regulatory networks linking transcriptome and metabolome to fruit quality traits remain poorly understood in non‐climacteric crop species ...
Wesley Elias Bhering Barrios +12 more
wiley +1 more source
Endocrine and Metabolic ScienceNeurological disorders are associated with decreased blood supply to the brain, neuronal damage, oxidative stress, and inflammation. While treatments are limited, soluble epoxide hydrolase inhibitors can be useful in alleviating neurological disorders ...
Mamatha Gavisiddaiah +7 more
doaj +1 more source
Liver Soluble Epoxide Hydrolase Regulates Behavioral and Cellular Effects of Chronic Stress
Cell Reports, 2019 Summary: Major depression is a serious global health concern; however, the pathophysiology underlying this condition remains unclear. While numerous studies have focused on brain-specific mechanisms, few have evaluated the role of peripheral organs in ...
Xi-He Qin +11 more
doaj +1 more source
Supplementary Data from Sorafenib has soluble epoxide hydrolase inhibitory activity, which contributes to its effect profile in vivo [PDF]
, 2009 Supplementary Data from Sorafenib has soluble epoxide hydrolase inhibitory activity, which contributes to its effect profile in ...
Bruce D. Hammock (65754) +5 more
core +1 more source
Frontiers in Pharmacology, 2019 Psychiatric disorders, including depression and schizophrenia, affect millions of individuals worldwide. However, the precise neurobiology of psychiatric disorders remains unclear. Accumulating evidence suggests that various inflammatory processes play a
Qian Ren, Qian Ren
doaj +1 more source
Soluble Epoxide Hydrolase Inhibition Protected against Angiotensin II-induced Adventitial Remodeling
Scientific Reports, 2017 Epoxyeicosatrienoic acids (EETs), the metabolites of cytochrome P450 epoxygenases derived from arachidonic acid, exert important biological activities in maintaining cardiovascular homeostasis.
Chi Zhou +5 more
doaj +1 more source
Regulation of the soluble epoxide hydrolase by peroxynitrite
The FASEB Journal, 2008 Inhibition of the soluble epoxide hydrolase (sEH), which for example converts epoxyeicosatrienoic acids to dihydroxyeicosatrienoic acids (DHETs), has anti‐inflammatory as well as anti‐hypertensive effects. As the enzymatic core of the sEH hydrolase domain contains two tyrosine residues (Tyr383 & 466), we addressed the hypothesis that the activity ...
Eduardo Barbosa‐Sicard +3 more
openaire +1 more source
The Emerging Parkinson's Disease Oxylipin‐Ome
Advanced Science, Volume 13, Issue 33, 15 June 2026.ABSTRACT Parkinson Disease (PD) is increasingly considered a proteinopathy and lipidopathy. This proteinopathy+lipidopathy paradigm has been further refined to a fatty acid (FA)‐opathy, centering dysregulated FA metabolism as fundamental in PD lipid dysfunction.
Julia C. Kelliher, Saranna Fanning
wiley +1 more source