Results 111 to 120 of about 7,307 (207)

Deletion of soluble epoxide hydrolase attenuates mice Hyperoxic acute lung injury

BMC Anesthesiology, 2018
Background Recent studies reported that soluble epoxide hydrolase (sEH) plays an important role in lung diseases. However, the role of sEH in hyperoxia-induced ALI is unclear.
Li-Ping Liu, Bin Li, Tian-Kui Shuai, Lei Zhu, Yu-Min Li   +4 more
doaj   +1 more source

Identification of potent inhibitors of the chicken soluble epoxide hydrolase [PDF]

, 2015
In vertebrates, soluble epoxide hydrolase (sEH) hydrolyzes natural epoxy-fatty acids (EpFAs), which are chemical mediators modulating inflammation, pain, and angiogenesis.
Harris, Todd R, Hammock, Bruce D, Lee, Kin Sing S, Yang, Jun, Merzlikin, Oleg, Shihadih, Diyala S, Morisseau, Christophe   +6 more
core   +1 more source

Enzyme inhibition kinetics of MMU on human soluble epoxide hydrolase. [PDF]

, 2015
Enzyme kinetic analysis was performed on recombinant human soluble epoxide hydrolase (2 nM) using [3H] t-DPPO as a substrate. For each substrate concentration (4.0–30.0 μM), the velocity was plotted as a function of inhibitor concentration (0–1000 nM ...
Maximilienne Nyegue (690549), Bruce D. Hammock (65754), Shizuo G. Kamita (192776), Christophe Morisseau (362750), Gina R. De Nicola (690548), Bora Inceoglu (495917), Seiya Kitamura (690547)   +6 more
core   +1 more source

Evaluation of fish models of soluble epoxide hydrolase inhibition.

Environmental Health Perspectives, 2001
Substituted ureas and carbamates are mechanistic inhibitors of the soluble epoxide hydrolase (sEH). We screened a set of chemicals containing these functionalities in larval fathead minnow (Pimphales promelas) and embryo/larval golden medaka (Oryzias latipes) models to evaluate the utility of these systems for investigating sEH inhibition in vivo. Both
J W, Newman, D L, Denton, C, Morisseau, C S, Koger, C E, Wheelock, D E, Hinton, B D, Hammock   +6 more
openaire   +2 more sources

Theoretical study of the full reaction mechanism of human soluble epoxide hydrolase [PDF]

, 2006
The complete reaction mechanism of soluble epoxide hydrolase (sEH) has been investigated by using the B3LYP density functional theory method. Epoxide hydrolases catalyze the conversion of epoxides to their corresponding vicinal diols.
Himo, Fahmi,, Hopmann, Kathrin H.,
core   +1 more source

Deficiency of Soluble Epoxide Hydrolase Protects Cardiac Function Impaired by LPS-Induced Acute Inflammation

Frontiers in Pharmacology, 2019
Lipopolysaccharide (LPS) is a bacterial wall endotoxin producing many pathophysiological conditions including myocardial inflammation leading to cardiotoxicity.
Victor Samokhvalov, K. Lockhart Jamieson, Ahmed M. Darwesh, Hedieh Keshavarz-Bahaghighat, Tim Y. T. Lee, Matthew Edin, Fred Lih, Darryl C. Zeldin, John M. Seubert, John M. Seubert   +9 more
doaj   +1 more source

Discovery of the First in Vivo Active Inhibitors of the Soluble Epoxide Hydrolase Phosphatase Domain [PDF]

, 2019
The emerging pharmacological target soluble epoxide hydrolase (sEH) is a bifunctional enzyme exhibiting two different catalytic activities that are located in two distinct domains.
Brunst, Steffen, Heering, Jan, Bellien, Jeremy, Wittmann, Sandra, K, Hiesinger, Kerstin, Wittmann, Sandra,, Kramer, Jan S, Rovati, GE, Sala, Angelo, Rondeaux, Julie, Hernandez-Olmos, Victor, Hammock, Bruce, Rovati, Enrico, G, Lillich, Felix,, Woltersdorf, Stefano, Proschak, Ewgenij, Klingler, Franca-M, Duflot, Thomas, Buccellati, Carola, Knapp, Stefan, Hammock, Bruce D, Merk, Daniel, Rovati, G Enrico, Rovati, Enrico,, Lillich, Felix, F, Pogoryelov, Denys, Fraineau, Sylvain, Morisseau, Christophe, Wittmann, Sandra K, Leuillier, Matthieu, Chaikuad, Apirat, Knöll, Felix, Lillich, Felix F, Steinhilber, Dieter, Kramer, Jan   +34 more
core   +1 more source

Soluble epoxide hydrolase inhibition decreases reperfusion injury after focal cerebral ischemia

Scientific Reports, 2018
Epoxyeicosatrienoic acids (EETs) are produced by cytochrome P450 epoxygenases from arachidonic acid, and their rapid metabolism is mainly through soluble epoxide hydrolase (sEH).
Ranran Tu, Jillian Armstrong, Kin Sing Stephen Lee, Bruce D. Hammock, Adam Sapirstein, Raymond C. Koehler   +5 more
doaj   +1 more source

Soluble Epoxide Hydrolase Inhibitors: New Molecules with Potential for Use in Veterinary Medicine [PDF]

, 2014
Treatments for inflammation and pain are important consideration in human and veterinary medicine. The classical drugs for treatments of inflammation and pain act by inhibition of cyclooxygenase and lypoxygenase pathways. However, there is still a need
Giorgi M., DE VITO, Virginia, Lee HK
core   +2 more sources

Editorial: Clinical Paths for Soluble Epoxide Hydrolase Inhibitors

Frontiers in Pharmacology, 2020
John D. Imig, Christophe Morisseau
doaj   +1 more source