Results 111 to 120 of about 507,315 (208)

Isolation of a putative hydroxyacyl enzyme intermediate of an epoxide hydrolase

, 1994
A putative covalent, alpha-hydroxyacyl intermediate was isolated by the brief exposure of murine soluble epoxide hydrolase to its substrate. The reaction was reversed by time and blocked by competitive inhibitors.
Hammock, B D, Oesch, F, Pinot, F, Beetham, J K, Grant, D F, Arand, Michael E; https://orcid.org/   +5 more
core   +1 more source

Soluble epoxide hydrolase inhibitory activity of phenolic components from the rhizomes and roots of Gentiana scabra

, 2015
Two new (1 and 2) and seven known phenolic compounds were isolated from a methanol extract of the rhizomes and roots of Gentiana scabra. Their structures were identified by spectroscopic analysis and comparing with reported values. The inhibitory effects
Jang Hoon Kim (683664), Wei Li (7081), Jin Yeul Ma (299100), Young Ho Kim (121751), Sang Hee Shim (683665), Wei Zhou (24328)   +5 more
core   +1 more source

The involvement of soluble epoxide hydrolase in the development of cardiovascular diseases through epoxyeicosatrienoic acids

Frontiers in Pharmacology
Arachidonic acid (AA) has three main metabolic pathways: the cycloxygenases (COXs) pathway, the lipoxygenases (LOXs) pathway, and the cytochrome P450s (CYPs) pathway. AA produces epoxyeicosatrienoic acids (EETs) through the CYPs pathway.
Shan Jiang, Shan Jiang, Siyi Han, Dao Wen Wang, Dao Wen Wang   +4 more
doaj   +1 more source

Stereo- and enantioselectivity of the soluble epoxide hydrolase-catalysed hydrolysis of (+/-)-cis-dialkyl substituted oxiranes

, 1999
Both enantiomers of cis-(+/-)-2,3-epoxyheptane (1a), cis-3,4-epoxyheptane (1b), cis-3,4-epoxynonane (1c) cis-3,4-epoxynonane-1-ol (1d) and cis-1-methoxy-3,4-epoxynonane (1e) are transformed into the corresponding threo-diols 2a-e by soluble epoxide ...
Palese CD, CHIAPPE, CINZIA
core   +1 more source

Bifunctional catalysis in human epoxide hydrolase

, 2006
The X-ray crystal structure of human soluble epoxide hydrolase (sEH) has been determined at 2.6 Å resolution, revealing a domain-swapped quaternary structure identical to that observed for the murine enzyme [Argiriadi, M.A., Morisseau, C., Hammock, B.D.,
Gomez, German Ariel
core  

Downregulation of osteoclast differentiation and activation by the soluble epoxide hydrolase inhibition. [PDF]

J Pharmacol Exp Ther
Martins G, Oliveira D, Rivas CA, Clemente-Napimoga JT, Hammock BD, Van Dyke TE, Napimoga MH, Abdalla HB.   +7 more
europepmc   +1 more source

TPPU, a soluble epoxide hydrolase inhibitor, mitigates Aβ-induced neurotoxicity via dual modulation of mitochondrial stabilization and JNK suppression. [PDF]

Biochem Biophys Rep
Song J, He A, Li S, Wu Q.
europepmc   +1 more source

Allosteric ensembles elucidate mechanisms of inhibition in the human soluble epoxide hydrolase. [PDF]

Commun Biol
Qiu Q, Gracia Carmona O, Abis G, Fraternali F, Conte MR.   +4 more
europepmc   +1 more source

Fragment-Based Discovery of Fenamic Acids as Pan-Species Inhibitors of the Soluble Epoxide Hydrolase Phosphatase Domain. [PDF]

ACS Chem Biol
Zhu WF, Feugray G, Brunst S, Messaoudi H, Yang M, Martinez-Conde N, Krämer A, Weizel L, Ehrler JMH, Kramer JS, Kaiser A, Al-Tarrass M, Pereira T, Valet M, Brunel V, Schubert-Zsilavecz M, Knapp S, Lillich FF, Hernandez-Olmos V, Duflot T, Hiesinger K, Qian H, Proschak A, Bellien J, Proschak E.   +24 more
europepmc   +1 more source

Supplementary information Novel Soluble Epoxide Hydrolase Inhibitor: Toward Regulatory Preclinical Studies

Neuroinflammation is widely recognized as a key pathological hallmark of Alzheimer’s disease (AD). Recently, inhibiting soluble epoxide hydrolase (sEH) has emerged as a promising therapeutic strategy for AD.
Sanfeliu, Coral, Codony, Sandra, Sánchez, Javier, Müller, Christa E., Vazquez, Santiago, Griñán-Ferré, Christian, Schneider, Marion, Jarne-Ferrer, Júlia, Pallàs, Mercè, Franco, Rafael   +9 more
core   +1 more source