Results 101 to 110 of about 7,307 (207)

Naturally occurring monoepoxides of eicosapentaenoic acid and docosahexaenoic acid are bioactive antihyperalgesic lipids[S]

Journal of Lipid Research, 2010
Beneficial physiological effects of long-chain n-3 polyunsaturated fatty acids are widely accepted but the mechanism(s) by which these fatty acids act remains unclear.
Christophe Morisseau, Bora Inceoglu, Kara Schmelzer, Hsing-Ju Tsai, Steven L. Jinks, Christine M. Hegedus, Bruce D. Hammock   +6 more
doaj   +1 more source

Electrochemical Hofmann Rearrangement for Modular Synthesis of Unsymmetrical Ureas and Late‐Stage Modification of Drugs

Advanced Science, Volume 13, Issue 31, 4 June 2026.
An electrochemical Hofmann rearrangement of amide involving amine or other amide nucleophiles has been developed. The use of NaI guarantees the feasibility and compatibility of the electrosynthesis protocol, which enables highly chemoselective synthesis of unsymmetrical N‐acylureas from two different amides, as well as the production of unsymmetrical ...
Xue‐Qing Mou, Xiao Zha, Yu‐Rui Jian, Shao‐Xing Zhong, Xin‐Yu Fu, Sheng‐Yang Xu, Wei Xiang, Bao‐Dong Cui, Yun Zhang, Yong‐Zheng Chen   +9 more
wiley   +1 more source

Orally Bioavailable Potent Soluble Epoxide Hydrolase Inhibitors [PDF]

, 2016
A series of N,N‘-disubstituted ureas having a conformationally restricted cis- or trans-1,4-cyclohexane α to the urea were prepared and tested as soluble epoxide hydrolase (sEH) inhibitors.
Bruce D. Hammock (65754), Christophe Morisseau (362750), Jun-Yan Liu (192782), Sung Hee Hwang (495922), Hsing-Ju Tsai (2131708)   +4 more
core   +1 more source

Soluble epoxide hydrolase inhibition modulates vascular remodeling

American Journal of Physiology-Heart and Circulatory Physiology, 2010
The soluble epoxide hydrolase enzyme (SEH) and vascular remodeling are associated with cardiovascular disease. Although inhibition of SEH prevents smooth muscle cell proliferation in vitro, the effects of SEH inhibition on vascular remodeling in vivo and mechanisms of these effects remain unclear.
A N, Simpkins, R D, Rudic, S, Roy, H J, Tsai, B D, Hammock, J D, Imig   +5 more
openaire   +3 more sources

Genetic deletion of soluble epoxide hydrolase delays the progression of Alzheimer’s disease

Journal of Neuroinflammation, 2019
Background Soluble epoxide hydrolase (sEH) is a bifunctional enzyme with COOH-terminal hydrolase and NH2-terminal lipid phosphatase activities. It is expressed in various cell types in the brain and is involved in the pathogenesis of inflammatory and ...
Hsueh-Te Lee, Kuan-I Lee, Chia-Hui Chen, Tzong-Shyuan Lee   +3 more
doaj   +1 more source

Asp333, Asp495, and His523 form the catalytic triad of rat soluble epoxide hydrolase [PDF]

, 1996
On the basis of the sequence similarity between mammalian epoxide hydrolases and bacterial haloalkane dehalogenase reported earlier (Arand, M., Grant, D. F., Beetham, J. K., Friedberg, T., Oesch, F., and Hammock, B. D. (1994) FEBS Lett.
Oesch, F, Wagner, H, Arand, Michael; https://orcid.org/   +2 more
core   +1 more source

Pharmaceutical Effects of Inhibiting the Soluble Epoxide Hydrolase in Canine Osteoarthritis

Frontiers in Pharmacology, 2019
Osteoarthritis (OA) is a degenerative joint disease that causes pain and bone deterioration driven by an increase in prostaglandins (PGs) and inflammatory cytokines.
Cindy B. McReynolds, Cindy B. McReynolds, Sung Hee Hwang, Sung Hee Hwang, Jun Yang, Jun Yang, Debin Wan, Karen Wagner, Karen Wagner, Christophe Morisseau, Dongyang Li, William K. Schmidt, Bruce D. Hammock, Bruce D. Hammock   +13 more
doaj   +1 more source

Soluble Epoxide Hydrolase Inhibitory Activity of Selaginellin Derivatives from Selaginella tamariscina

Molecules, 2015
Selaginellin derivatives 1–3 isolated from Selaginella tamariscina were evaluated for their inhibition of soluble epoxide hydrolase (sEH) to demonstrate their potential for the treatment of cardiovascular disease.
Jang Hoon Kim, Chong Woon Cho, Bui Huu Tai, Seo Young Yang, Gug-seoun Choi, Jong Seong Kang, Young Ho Kim   +6 more
doaj   +1 more source

Soluble Epoxide Hydrolase Inhibition for Ocular Diseases: Vision for the Future

Frontiers in Pharmacology, 2019
Ocular diseases cause visual impairment and blindness, imposing a devastating impact on quality of life and a substantial societal economic burden. Many such diseases lack universally effective pharmacotherapies.
Bomina Park, Bomina Park, Timothy W. Corson, Timothy W. Corson, Timothy W. Corson   +4 more
doaj   +1 more source

Bifunctional catalysis in human epoxide hydrolase [PDF]

, 2006
The X-ray crystal structure of human soluble epoxide hydrolase (sEH) has been determined at 2.6 Å resolution, revealing a domain-swapped quaternary structure identical to that observed for the murine enzyme [Argiriadi, M.A., Morisseau, C., Hammock, B.D.,
Gomez, German Ariel
core