Results 81 to 90 of about 507,315 (208)

Insights into the potential role of sEH inhibition in the prevention and progression of neurological disorders

Endocrine and Metabolic Science
Neurological disorders are associated with decreased blood supply to the brain, neuronal damage, oxidative stress, and inflammation. While treatments are limited, soluble epoxide hydrolase inhibitors can be useful in alleviating neurological disorders ...
Mamatha Gavisiddaiah, Sumanta Kumar Goswami, Manali Somanna, Bruce D. Hammock, Kenganora Mruthunjaya, Abigail Fielding, Dithu Thekkekkara, Santhepete Nanjundaiah Manjula   +7 more
doaj   +1 more source

Liver Soluble Epoxide Hydrolase Regulates Behavioral and Cellular Effects of Chronic Stress

Cell Reports, 2019
Summary: Major depression is a serious global health concern; however, the pathophysiology underlying this condition remains unclear. While numerous studies have focused on brain-specific mechanisms, few have evaluated the role of peripheral organs in ...
Xi-He Qin, Zhou Wu, Jing-Hua Dong, Yuan-Ning Zeng, Wen-Chao Xiong, Ce Liu, Meng-Yao Wang, Min-Zhen Zhu, Wen-Jun Chen, Yuan Zhang, Qi-Yuan Huang, Xin-Hong Zhu   +11 more
doaj   +1 more source

Reorganization of Innate Immune Cell Lipid Profiles by Bioinspired Meroterpenoids to Limit Inflammation

Advanced Science, Volume 13, Issue 59, 23 October 2026.
Resolution pharmacology is an emerging strategy to tackle inflammatory pathologies. Bioinspired meroterpenoids induce a lipid mediator class switch toward inflammation resolution in vitro and in vivo by targeting key nodes in lipid mediator biosynthesis and neutral lipid dynamics.
Lorenz Waltl, David Holubek, Klaus Speck, Raphael Wildermuth, Franz‐Lucas Haut, Stephan Permann, Immanuel Plangger, Christian Steinborn, Zhigang Rao, Danilo D'Avino, Ida Cerqua, Julia Stadler, Fiorentina Roviezzo, Peter Schlenke, Anita Siller, Harald Schennach, Solveigh C. Koeberle, Eva‐Maria Pferschy‐Wenzig, Antonietta Rossi, Thomas Magauer, Andreas Koeberle   +20 more
wiley   +1 more source

Identification of Food-Derived Peptide Inhibitors of Soluble Epoxide Hydrolase

, 2023
Over the course of more than ten years, there has been a significant increase in the approach employed to inhibit the function of soluble epoxide hydrolase (sEH).
Obeme-Nmom, Joy
core   +1 more source

Soluble Epoxide Hydrolase Regulation of Lipid Mediators Limits Pain [PDF]

, 2020
The role of lipids in pain signaling is well established and built on decades of knowledge about the pain and inflammation produced by prostaglandin and leukotriene metabolites of cyclooxygenase and lipoxygenase metabolism, respectively.
Hammock, Bruce D, Gomes, Aldrin, McReynolds, Cindy B, Wagner, Karen M, Karen M. Wagner, Aldrin Gomes, Bruce D. Hammock, Cindy B. McReynolds   +7 more
core   +1 more source

Soluble Epoxide Hydrolase Inhibitor: A Novel Potential Therapeutic or Prophylactic Drug for Psychiatric Disorders

Frontiers in Pharmacology, 2019
Psychiatric disorders, including depression and schizophrenia, affect millions of individuals worldwide. However, the precise neurobiology of psychiatric disorders remains unclear. Accumulating evidence suggests that various inflammatory processes play a
Qian Ren, Qian Ren
doaj   +1 more source

Progress report on new epilepsy treatments: A summary of the Eighteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XVIII). II. Treatments in more advanced clinical development

Epilepsia, Volume 67, Issue 10, Page 5075-5125, October 2026.
Abstract This article summarizes data for 13 investigational treatments for which at least preliminary seizure outcome data in patients with epilepsy were reported at the Eighteenth Eilat Conference on New Antiepileptic Drugs and Devices held in Madrid, Spain, on May 3–6, 2026.
Meir Bialer, Cecilie Johannessen Landmark, Matthias J. Koepp, Emilio Perucca, Piero Perucca, Torbjörn Tomson, H. Steve White, Elaine Wirrell   +7 more
wiley   +1 more source

Soluble Epoxide Hydrolase Inhibition Protected against Angiotensin II-induced Adventitial Remodeling

Scientific Reports, 2017
Epoxyeicosatrienoic acids (EETs), the metabolites of cytochrome P450 epoxygenases derived from arachidonic acid, exert important biological activities in maintaining cardiovascular homeostasis.
Chi Zhou, Jin Huang, Qing Li, Jiali Nie, Xizhen Xu, Dao Wen Wang   +5 more
doaj   +1 more source

Panax notoginseng Saponins Accelerate Diabetic Wound Repair by Minimizing Mitochondrial Dysfunction and Inhibiting Pyroptosis of Macrophage via Regulating Ephx2/11,12‐EET Axis

Food Science &Nutrition, Volume 14, Issue 10, October 2026.
Panax notoginseng saponins (PNS) accelerate diabetic wound healing via targeting the Ephx2/11,12‐EET axis in macrophages. PNS inhibits Ephx2 expression to elevate 11,12‐EET levels, which restores mitochondrial homeostasis by regulating mitochondrial dynamic proteins, reduces mtROS production, and subsequently suppresses NLRP3 inflammasome‐mediated ...
Nan Chen, Bo Zhu, Cai‐hua Sun, Tong Hou   +3 more
wiley   +1 more source

Flavonoids as Modulators of Lipid Mediator Signaling: A Narrative Review on Mechanisms, Current Evidence, and Gaps in the Literature

Molecular Nutrition &Food Research, Volume 70, Issue 20, 28 October 2026.
Flavonoid consumption may modulate phospholipase activity and COX‐, LOX‐, and CYP450‐dependent oxylipin biosynthesis, reshaping lipid mediator networks. Emerging evidence suggests these shifts may favor inflammatory resolution over propagation, with implications for metabolic, cardiovascular, and neuroinflammatory disease risk.
Joseph Arballo, Mary Ann Lila
wiley   +1 more source