Results 61 to 70 of about 507,315 (208)

Effects of Glyphosate and Glyphosate‐Based Herbicides on the Mammalian Gut Microbiome: A Critical Review

Journal of Applied Toxicology, EarlyView.
ABSTRACT Glyphosate has long been considered to pose negligible direct risk to mammals on the grounds that its molecular target, 5‐enolpyruvylshikimate‐3‐phosphate synthase (EPSPS), of the shikimate pathway, is absent from animal cells. This rationale is inaccurate as a complete toxicological argument, because the shikimate pathway is present in some ...
Robin Mesnage
wiley   +1 more source

Soluble Epoxide Hydrolase

Asian Journal of Pharmaceutical Research and Development
Epoxyeicosatrienoic acids (EETs) have numerous cardiovascular benefits, including vasodilation, anti-inflammatory actions, and anti-migratory effects on vascular smooth muscle cells. However, sEH, an enzyme that breaks down EETs into diols, limits these benefits.
Pooja M. Sontakke, Suraj G. Malpani, Pooja R. Tange, MD Rayees Ahmad, Vishweshwar M. Dharashive   +4 more
openaire   +1 more source

Visualization of a covalent intermediate between microsomal epoxide hydrolase, but not cholesterol epoxide hydrolase, and their substrates

, 1997
Mammalian soluble and microsomal epoxide hydrolases have been proposed to belong to the family of alpha/beta-hydrolase-fold enzymes. These enzymes hydrolyse their substrates by a catalytic triad, with the first step of the enzymatic reaction being the ...
Willy Hinz, Oesch, F, Seidel, A, Blée, E, Albrecht Seidel, Hinz, W, Frank Müller, Lars Winkler, Arand, Michael; https://orcid.org/, Hänel, K, Beetham, J K, Heinz Frank, Franz Oesch, Hammock, B D, Karen Hänel, Bruce D. Hammock, Elizabeth Blée, Jeffrey K. Beetham, Müller, F, Michael Arand, Frank, H, Winkler, L   +21 more
core   +1 more source

Synthesis of Microbial‐Derived Octadecanoids

Lipids, EarlyView.
C18‐carbon containing dietary polyunsaturated fatty acids (e.g., linoleic acid, α‐linolenic acid, and γ‐linolenic acid) are metabolized by bacteria in the gut into oxygenated lipid mediators termed octadecanoids. To study the biological function of these compounds, we report here the chemical synthesis of multiple octadecanoids.
Johanna Revol‐Cavalier, Katarína Bankóová, Olivier Salamin, Alessandro Quaranta, Juan Du, Mats Hamberg, Craig E. Wheelock   +6 more
wiley   +1 more source

Soluble Epoxide Hydrolase [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2012
Objective— Sex differences in cerebral ischemic injury are, in part, arrtibutable to the differences in cerebrovascular perfusion. We determined whether the brain microvascular endothelial cells (ECs) isolated from the female brain are more resistant to ischemic injury compared with male ECs, and whether the difference is ...
Nandita C, Gupta, Catherine M, Davis, Jonathan W, Nelson, Jennifer M, Young, Nabil J, Alkayed   +4 more
openaire   +2 more sources

Association between the soluble epoxide hydrolase gene and preeclampsia

Hypertension in Pregnancy, 2017
Objective: In this study the association between K55R polymorphism, methylation level of the EPHX2 promoter region, and PE was investigated in 520 individuals including 260 PE patients and 260 healthy pregnant women.
Ismail Sari, Hatice Pinarbasi, Ergun Pinarbasi, Caglar Yildiz   +3 more
doaj   +1 more source

2-(Piperidin-4-yl)acetamides as Potent Inhibitors of Soluble Epoxide Hydrolase with Anti-Inflammatory Activity

Pharmaceuticals, 2021
The pharmacological inhibition of soluble epoxide hydrolase (sEH) has been suggested as a potential therapy for the treatment of pain and inflammatory diseases through the stabilization of endogenous epoxyeicosatrienoic acids.
Juan Martín-López, Sandra Codony, Clara Bartra, Christophe Morisseau, María Isabel Loza, Coral Sanfeliu, Bruce D. Hammock, José Brea, Santiago Vázquez   +8 more
doaj   +1 more source

Analysis of Carbohydrates and Glycoconjugates by Matrix‐Assisted Laser Desorption/Ionization Mass Spectrometry: An Update for 2023–2024

Mass Spectrometry Reviews, EarlyView.
ABSTRACT The use of MALDI mass spectrometry for the analysis of carbohydrates and glycoconjugates is a well‐established technique and this comprehensive review is the twelfth update of the original article published in 1999 and brings coverage of the literature to the end of 2024.
David J. Harvey
wiley   +1 more source

Impact of the acute local inhibition of soluble epoxide hydrolase on diabetic skin microcirculatory dysfunction [PDF]

, 2019
International audienceThe impact of the local inhibition of soluble epoxide hydrolase, which metabolizes vasodilator and anti-inflammatory epoxyeicosanoids, on diabetic skin microvascular dysfunction was assessed. In diabetic db/db mice, basal skin blood
Richard, Vincent, Bellien, Jeremy, Roustit, Matthieu, Morisseau, Christophe, Hammock, Bruce, Skiba, Mohamed, Imbert, Laurent, Cornic, Marie, Thiébaut, Pierre-Alain, Picquenot, Jean-Michel, Savina, Yann, Kotzki, Sylvain, Duflot, Thomas, Cracowski, Jean-Luc, Serreau, Pierre-Alex, Bounoure, Frederic   +15 more
core   +1 more source

Physiological and anatomical determinants of placental drug transfer

The Journal of Physiology, EarlyView.
Abstract figure legend Fetal exposure to pharmaceuticals and their subsequent clearance back to the maternal circulation are governed by placental transfer. Passive diffusion down a maternal‐to‐fetal concentration gradient is the primary route of fetal drug exposure, with specific compounds undergoing transporter‐mediated transfer.
Rohan M. Lewis, Anandita Umapathy, Jane K. Cleal, Bram G. Sengers   +3 more
wiley   +1 more source