Results 1 to 10 of about 11,381 (191)

A Comprehensive Analysis of Epoxide Hydrolase 2 (EPHX2) in Pan‐Cancer [PDF]

Cancer Reports
Background and Aims Epoxide hydrolase 2 (EPHX2) regulates lipid signaling across various metabolites by encoding soluble epoxide hydrolase. However, its mechanisms and implications in human malignancies remain unknown.
Weiquan Hu, Xiaoli Ding, Xiangsheng Wu, Xuxiang Xi, Jing Xu, Shengyun Dai, Jing Chen, Suping Hu, Qinfei Zhao, Fangfang Chen   +9 more
doaj   +5 more sources

Association of Epoxide Hydrolase 2 Gene Arg287Gln with the Risk for Primary Hypertension in Chinese [PDF]

International Journal of Hypertension, 2020
Background. Epoxide hydrolase 2 (EPHX2) gene coding for soluble epoxide hydrolase is a potential candidate in the pathogenesis of hypertension. Objectives.
Liang Ma, Hailing Zhao, Meijie Yu, Yumin Wen, Tingting Zhao, Meihua Yan, Qian Liu, Yongwei Jiang, Yongtong Cao, Ping Li, Wenquan Niu   +10 more
doaj   +4 more sources

Mechanism of protection by soluble epoxide hydrolase inhibition in type 2 diabetic stroke. [PDF]

PLoS ONE, 2014
Inhibition of soluble epoxide hydrolase (sEH) is a potential target of therapy for ischemic injury. sEH metabolizes neuroprotective epoxyeicosatrienoic acids (EETs).
Kristen L Zuloaga, Stephanie M Krasnow, Xinxia Zhu, Wenri Zhang, Sari A Jouihan, Robert E Shangraw, Nabil J Alkayed, Daniel L Marks   +7 more
doaj   +5 more sources

Regulation Roles of Juvenile Hormone Epoxide Hydrolase Gene 2 in the Female River Prawn Macrobrachium nipponense Reproductive Process [PDF]

Current Issues in Molecular Biology
In this study, we investigated the regulatory roles of the juvenile hormone epoxide hydrolase (JHEH) gene in the reproductive process of female Macrobrachium nipponense. Its total cDNA length was 1848 bp, encoding for 460 amino acids.
Jisheng Wang, Mengying Zhang, Hongtuo Fu, Wenyi Zhang, Yiwei Xiong, Shubo Jin, Hui Qiao, Sufei Jiang   +7 more
doaj   +6 more sources

2-(Piperidin-4-yl)acetamides as Potent Inhibitors of Soluble Epoxide Hydrolase with Anti-Inflammatory Activity [PDF]

Pharmaceuticals, 2021
The pharmacological inhibition of soluble epoxide hydrolase (sEH) has been suggested as a potential therapy for the treatment of pain and inflammatory diseases through the stabilization of endogenous epoxyeicosatrienoic acids.
Juan Martín-López, Sandra Codony, Clara Bartra, Christophe Morisseau, María Isabel Loza, Coral Sanfeliu, Bruce D. Hammock, José Brea, Santiago Vázquez   +8 more
doaj   +9 more sources

Cytochrome P450-soluble epoxide hydrolase derived linoleic acid oxylipins and cognitive performance in type 2 diabetes [PDF]

Journal of Lipid Research, 2023
Type 2 diabetes mellitus (T2DM) increases the risk of cognitive decline and dementia. Disruptions in the cytochrome P450-soluble epoxide hydrolase (CYP450-sEH) pathway have been reported in T2DM, obesity and cognitive impairment. We examine linoleic acid
Natasha Z. Anita, Felicia Kwan, Si Won Ryoo, Chelsi Major-Orfao, William Z. Lin, Shiropa Noor, Krista L. Lanctôt, Nathan Herrmann, Paul I. Oh, Baiju R. Shah, Jeremy Gilbert, Angela Assal, Ilana J. Halperin, Ameer Y. Taha, Walter Swardfager   +14 more
doaj   +6 more sources

A novel activity of microsomal epoxide hydrolase: metabolism of the endocannabinoid 2-arachidonoylglycerol [PDF]

Journal of Lipid Research, 2014
Microsomal epoxide hydrolase (EPHX1, EC 3.3.2.9) is a highly abundant α/β-hydrolase enzyme that is known for its catalytical epoxide hydrolase activity.
Kasem Nithipatikom, Michael P. Endsley, Adam W. Pfeiffer, John R. Falck, William B. Campbell   +4 more
doaj   +4 more sources

Characterization of an isobutylene epoxide hydrolase (IbcK) from the isobutylene-catabolizing bacterium Mycolicibacterium sp. ELW1 [PDF]

Applied and Environmental Microbiology
Isobutylene (IB) is produced on a large scale by the petrochemical industry and is metabolized by the aerobic alkene-metabolizing bacterium Mycolicibacterium sp. ELW1. The initial metabolite of IB catabolism by this bacterium is proposed to be 2-methyl-1,
Nicholas W. Faulkner, John B. Joyce, Christy Smith, Paul Swartz, Robert B. Rose, Eric S. Miller, Michael R. Hyman   +6 more
doaj   +2 more sources

Inhibition of soluble epoxide hydrolase in endotoxin induced pig lung injury [PDF]

Frontiers in Pharmacology
Pharmacological inhibition of soluble epoxide hydrolase has been shown to attenuate lung injury development in rodents exposed to bacterial lipopolysaccharide. To investigate if these effects can be reproduced in larger animals, we tested soluble epoxide
Niklas Larsson, Cindy B. McReynolds, Sung Hee Hwang, Debin Wan, Jun Yang, Richard Lindberg, Stefan Lehtipalo, Jonas Claesson, Amanda Irgum Liljeström, Alicia Lind, Anders Brolin, Martin Isaksson Mettävainio, Bruce D. Hammock, Christophe Morisseau, Malin L. Nording, Malin L. Nording   +15 more
doaj   +2 more sources

Inhibitory Activity of Quercetin 3-O-Arabinofuranoside and 2-Oxopomolic Acid Derived from Malus domestica on Soluble Epoxide Hydrolase [PDF]

Molecules, 2020
Flavonoids and triterpenoids were revealed to be the potential inhibitors on soluble epoxide hydrolase (sEH). The aim of this study is to reveal sEH inhibitors from Fuji apples.
In Sook Cho, Jang Hoon Kim, Yunjia Lin, Xiang Dong Su, Jong Seong Kang, Seo Young Yang, Young Ho Kim   +6 more
doaj   +2 more sources