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Alterations of Bioactive Lipid Profiles in the Retina Following Traumatic Optic Neuropathy in Mice. [PDF]

Biomolecules
Kim MY, Koneru N, Alahdab G, Risner M, Ibrahim AS, Maddipati KR, Al-Shabrawey M.   +6 more
europepmc   +1 more source

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Serum soluble epoxide hydrolase related oxylipins and major depression in patients with type 2 diabetes

Psychoneuroendocrinology, 2021
People with type 2 diabetes mellitus (T2DM) are at increased risk for depression. Both conditions are associated with disturbances in polyunsaturated fatty acids. Omega-3 and omega-6 fatty acids can be converted into bioactive epoxides by cytochrome P450s (CYP450), which play pro-resolving roles in the inflammatory response; however, soluble epoxide ...
Natasha Z, Anita, Nubaira, Forkan, Radia, Kamal, Michelle M, Nguyen, Di, Yu, Chelsi, Major-Orfao, Sophie K, Wong, Krista L, Lanctôt, Nathan, Herrmann, Paul I, Oh, Baiju R, Shah, Jeremy, Gilbert, Angela, Assal, Ilana J, Halperin, Theresa L, Pedersen, Ameer Y, Taha, Walter, Swardfager   +16 more
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Metabolism of epoxidized phosphatidylcholine by phospholipase A₂ and epoxide hydrolase

Lipids, 1981
AbstractThe isolation and measurement of phospholipid epoxides as major peroxidation products in biomembrane preparations prompted an investigation of enzymatic mechanisms which may be responsible for their elimination. Analysis of microsomal epoxide hydrolase and phospholipase A2 activity against a phospholipid epoxide commonly encountered in tissues ...
A, Sevanian, R A, Stein, J F, Mead
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Enantioselective Hydrolysis of 2, 2-Disubstituted Oxiranes Mediated by Microsomal Epoxide Hydrolase

Synthetic Communications, 1995
Abstract 2-Aryl-2-methyloxiranes are enantioselectively hydrolyzed with microsomal epoxide hydrolase from pig liver to provide 1, 2-diols containing a tertiary benzylic alcohol stereogenic centre upto 34% enantio-meric purities.
Deevi Basavaiah, Sarikonda Bhaskar Raju
openaire   +1 more source