Results 151 to 160 of about 8,971 (179)

Association of soluble epoxide hydrolase gene polymorphism with insulin resistance in type 2 diabetic patients

Biochemical and Biophysical Research Communications, 2005
The insulin resistance found in diabetes is influenced by vascular tone and local blood flow. Endothelial-derived hyperpolarizing factor (EDHF) functions as a potent vasodilator to regulate vascular tone, and its production is regulated by soluble epoxide hydrolase (sEH).
Kentaro Ohtoshi, Hideaki Kaneto, Koichi Node, Yumiko Nakamura, Toshihiko Shiraiwa, Munehide Matsuhisa, Yoshimitsu Yamasaki   +6 more
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Metabolism of tridiphane (2-(3,5-dichlorophenyl)-2(2,2,2-trichloroethyl)oxirane) by hepatic epoxide hydrolases and glutathione S-transferases in mouse

Toxicology and Applied Pharmacology, 1987
The transformation of the herbicide tridiphane (Tandem, Dowco 356, 2-(3,5-dichlorophenyl)-2(2,2,2-trichloroethyl)oxirane by the epoxide-metabolizing enzymes, epoxide hydrolases (EH) and glutathione S-transferases (GST), was investigated in mouse liver microsomes and cytosol. The microsomal EH catalyzed the formation of tridiphane diol.
Jacques Magdalou, Bruce D. Hammock
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Inhibition of epoxide hydrolases and glutathione S-transferases by 2-, 3-, and 4-substituted derivatives of 4′-phenylchalcone and its oxide

Archives of Biochemistry and Biophysics, 1987
4'-Phenylchalcones, chalcone oxides, and related compounds were synthesized and tested as inhibitors of cytosolic epoxide hydrolase, microsomal epoxide hydrolase, and glutathione S-transferases from mouse and rat liver. Several compounds were more potent inhibitors of the cytosolic epoxide hydrolase than the parent 4'-phenylchalcone oxide while large ...
Toru Miyamoto, Marilyn Silva, Bruce D. Hammock   +2 more
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Organ distribution of epoxide hydrolases in cytosolic and microsomal fractions of normal and nafenopin-treated male DBA/2 mice

Biochemical Pharmacology, 1988
Using trans-stilbene oxide and styrene oxide as substrates, epoxide hydrolase activities were measured in cytosolic and microsomal fractions from liver, kidney, heart, lung and testis of male DBA/2 mice. The activities towards these two substrates are remarkably organ specific: trans-stilbene oxide was most effectively hydrolyzed in subcellular ...
Felix Waechter, P. Bentley, F. Bieri, Samar F. Muakkassah-Kelly, W. Stäubli, Monique Villermain   +5 more
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Preparation of (S)-2-, 3-, and 4-chlorostyrene oxides with the epoxide hydrolase from Sphingomonas sp. HXN-200

Tetrahedron: Asymmetry, 2008
Abstract The epoxide hydrolase from Sphingomonas sp. HXN-200 catalyzed the enantioselective hydrolysis of racemic 2-, 3-, and 4-chlorostyrene oxides 1 – 3 to form the corresponding ( R )-diols and gave the ( S )-epoxides 1 – 3 in high ee. The reactions were examined with frozen/thawed cells as well as cell-free extracts of Sphingomonas sp ...
Xin Jia, Zunsheng Wang, Zhi Li
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Enantioselectivities of yeast epoxide hydrolases for 1,2-epoxides

Tetrahedron: Asymmetry, 1999
Abstract Kinetic resolution of homologous series of unbranched 1,2-epoxyalkanes (C-4 to C-12), 1,2-epoxyalkenes (C-4, C-6 and C-8), a 2,2-dialkylsubstituted epoxide (2-methyl-1,2-epoxyheptane) and a benzyloxy-substituted epoxide (benzyl glycidyl ether) was investigated using resting cells of 10 different yeast strains.
Botes, A.L., Weijers, C.A.G.M., Botes, P.J., van Dyk, M.S.   +3 more
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Metabolism of epoxidized phosphatidylcholine by phospholipase A₂ and epoxide hydrolase

Lipids, 1981
AbstractThe isolation and measurement of phospholipid epoxides as major peroxidation products in biomembrane preparations prompted an investigation of enzymatic mechanisms which may be responsible for their elimination. Analysis of microsomal epoxide hydrolase and phospholipase A2 activity against a phospholipid epoxide commonly encountered in tissues ...
Robert A. Stein, James F. Mead, Alex Sevanian   +2 more
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Serum soluble epoxide hydrolase related oxylipins and major depression in patients with type 2 diabetes

Psychoneuroendocrinology, 2021
People with type 2 diabetes mellitus (T2DM) are at increased risk for depression. Both conditions are associated with disturbances in polyunsaturated fatty acids. Omega-3 and omega-6 fatty acids can be converted into bioactive epoxides by cytochrome P450s (CYP450), which play pro-resolving roles in the inflammatory response; however, soluble epoxide ...
Krista L. Lanctôt, Ameer Y. Taha, Radia Kamal, Di Yu, Michelle M. Nguyen, Nathan Herrmann, Paul Oh, Baiju R. Shah, Nubaira Forkan, Sophie K. Wong, Angela Assal, Ilana Halperin, Jeremy Gilbert, Walter Swardfager, Walter Swardfager, Walter Swardfager, Chelsi Major-Orfao, Natasha Z. Anita, Theresa L. Pedersen   +18 more
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Elevation of hepatic microsomal epoxide hydrolase activity by 2-acetylaminofluorene: role of metabolism

Carcinogenesis, 1985
Brief exposure of rats to hepatocarcinogenic agents causes a rapid elevation in hepatic microsomal epoxide hydrolase (EH) activity. Previous studies have demonstrated that animals which are resistant to the hepatocarcinogenic effects of 2-acetylaminofluorene (AAF) are also resistant to EH induction by this compound.
Dent Jg, Graichen Me
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Enantioselective Hydrolysis of 2, 2-Disubstituted Oxiranes Mediated by Microsomal Epoxide Hydrolase

Synthetic Communications, 1995
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
S. B. Raju, Deevi Basavaiah
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