Results 161 to 170 of about 8,971 (179)

Hydrolysis of the 2',3'-allylic epoxides of allylbenzene, estragole, eugenol, and safrole by both microsomal and cytosolic epoxide hydrolases.

Drug Metabolism and Disposition, 1992
2',3'-Allylic epoxide derivatives of allylbenzene and its analogs estragole, eugenol, and safrole were synthesized, and their enzymatic conversion to dihydrodiols by cytosolic and microsomal epoxide hydrolases was examined. All four epoxides were good substrates for both epoxide hydrolases, with Michaelis constants in the low micromolar range.
G, Luo, M K, Qato, T M, Guenthner
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Circulating epoxide hydrolase immunodeterminants in rats bearing hyperplastic nodules induced by 2-acetylaminofluorene☆

Cancer Letters, 1988
Epoxide hydrolase immunodeterminants (EH-immunodeterminants), as measured by a highly sensitive and specific enzyme-linked immunosorbent assay (ELISA), were detected in the sera of rats bearing hyperplastic liver nodules induced by feeding 2-acetylaminofluorene (2-AAF), while they were low or absent (less than 0.05 microgram/ml) in the sera of rats fed
Robert H. Broyles, Martin J. Griffin, Martin J. Griffin, Ram B. Palakodety   +3 more
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Biocatalytic resolution of 2-methyl-2-(aryl)alkyloxiranes using novel bacterial epoxide hydrolases

Tetrahedron: Asymmetry, 1997
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Wolfgang Kroutil, I. Osprian, Kurt Faber, M. Mischitz   +3 more
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Structure of epoxide hydrolase 2 from Mangifera indica throws light on the substrate specificity determinants of plant epoxide hydrolases

Biochemical and Biophysical Research Communications
Epoxide hydrolases (EHs) are a group of ubiquitous enzymes that catalyze hydrolysis of chemically reactive epoxides to yield corresponding dihydrodiols. Despite extensive studies on EHs from different clades, generic rules governing their substrate specificity determinants have remained elusive.
Ashwini Bhoite, Neeraj K. Gaur, Megha Palange, Ravindar Kontham, Vidya Gupta, Kiran Kulkarni   +5 more
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Stereoselective hydrolysis of 2,3-epoxysteroids by hepatic microsomal epoxide hydrolase

Biochemical and Biophysical Research Communications, 1971
Summary The present study was undertaken to clarify problems on the stereochemical course of the enzymatic hydrolysis of olefin oxides using 2α, 3α- and 2β, 3β-epoxy-5α-cholestanes (2α, 3α- and 2β, 3β-ECs, respectively) as model substrates for microsomal epoxide hydrolase.
Shoji Hara, Kazuko Akamatsu, Kazue Kiyonaga, Tadashi Watabe   +3 more
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Monensin biodegradation pathway and role of epoxide hydrolase in Stenotrophomonas maltophilia DM‐2

Journal of Chemical Technology & Biotechnology, 2020
AbstractBACKGROUNDMonensin is widely used in livestock and poultry production to promote animal growth and control coccidiosis. Most monensin is excreted as unchanged parent compounds via feces. However，monensin is very stable and difficult to degrade in the environment, and is potentially risky for the health of wildlife and humans.
Hao Li, Jie Li, Qiang Wan, Chuanwen Wang, Weiwei Sun, Jiayi Zhao, Yidan Xing, Baoliang Pan   +7 more
openaire   +2 more sources

Characterization of the induction of cytosolic and microsomal epoxide hydrolases by 2-ethylhexanoic acid in mouse liver.

Drug Metabolism and Disposition, 1987
When mice were exposed to 1% 2-ethylhexanoic acid in the diet, cytosolic and microsomal epoxide hydrolase (EC 3.3.2.3) activities were increased maximally (2-2.5- and 0.5-1-fold, respectively) after 3 days. Immunochemical quantitation of these enzymes indicated that the process involved was a true induction in both cases.
B, Lundgren, J, Meijer, J W, DePierre
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Enantioselective Hydrolysis of Functionalized 2,2-Disubstituted Oxiranes with Bacterial Epoxide Hydrolases

European Journal of Organic Chemistry, 2000
The biohydrolysis of 2,2-disubstituted oxiranes bearing various oxygen functional groups was investigated using the epoxide hydrolase activity of 11 bacterial strains. The results show that the activity and the selectivity strongly depend on the substrate structure and the biocatalyst.
Romano V. A. Orru, Kurt Faber, Sandra F. Mayer, Andreas Steinreiber, Ingrid Osprian   +4 more
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Inhibition of catalase and epoxide hydrolase by the renal cystogen 2-amino-4,5-diphenylthiazole and its metabolites

Toxicology, 1990
Subchronic feeding of 2-amino-4,5-diphenylthiazole (DPT) to rats results in the development of renal cysts and has been used as a model system to study polycystic kidney disease. Because previous studies revealed changes in renal enzymes following DPT administration, a possible direct effect of DPT and its phenolic metabolites on catalase and a related
Robert Whalen, Frank A. Carone, Thomas M. Guenthner, Kevin Bell, J. Thomas Hjelle, George Flouret   +5 more
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Studies on the Catalytic Promiscuity of Limonene Epoxide Hydrolases in the Non‐hydrolytic Ring Opening of 1,2‐Epoxides

ChemBioChem, 2020
AbstractThe non‐hydrolytic ring opening of 1,2‐epoxides in the presence of limonene epoxide hydrolases (LEHs) and different nucleophiles has been investigated. Lyophilized, wild‐type LEHs were tested in selected water‐saturated organic solvents in the presence of cyclohexene oxide as substrate and different alcohols, thiols and primary amines as ...
Bassanini I, Ferrandi EE, Monti D, Riva S   +3 more
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