Results 171 to 179 of about 8,971 (179)
Some of the next articles are maybe not open access.
Carcinogenesis, 1993
Liver microsomal epoxide hydrolase (mEH) is active in the detoxification of epoxide-containing carcinogens. The effects of thiazole and pyrazine, constituents of tobacco and tobacco smoke as well as of a variety of foods, on the expression and regulation of mEH were examined in rats (200 mg/kg body wt/day, i.p., 1-3 days).
Renu Batra +3 more
openaire +3 more sources
Liver microsomal epoxide hydrolase (mEH) is active in the detoxification of epoxide-containing carcinogens. The effects of thiazole and pyrazine, constituents of tobacco and tobacco smoke as well as of a variety of foods, on the expression and regulation of mEH were examined in rats (200 mg/kg body wt/day, i.p., 1-3 days).
Renu Batra +3 more
openaire +3 more sources
World Neurosurgery, 2017
We sought to simply demonstrate how levels of soluble human epoxide hydrolase-2 show changes in both temporal the cortex and hippocampal complex in patients with temporal lobe epilepsy.A total of 20 patients underwent anterior temporal lobe resection due to temporal lobe epilepsy.
Cihan Coskun +9 more
openaire +3 more sources
We sought to simply demonstrate how levels of soluble human epoxide hydrolase-2 show changes in both temporal the cortex and hippocampal complex in patients with temporal lobe epilepsy.A total of 20 patients underwent anterior temporal lobe resection due to temporal lobe epilepsy.
Cihan Coskun +9 more
openaire +3 more sources
Bioorganic & Medicinal Chemistry Letters, 2013
1-(1,3,5-Triazin-yl)piperidine-4-carboxamide inhibitors of soluble epoxide hydrolase were identified from high through-put screening using encoded library technology. The triazine heterocycle proved to be a critical functional group, essential for high potency and P450 selectivity.
Wensheng Xie +27 more
openaire +3 more sources
1-(1,3,5-Triazin-yl)piperidine-4-carboxamide inhibitors of soluble epoxide hydrolase were identified from high through-put screening using encoded library technology. The triazine heterocycle proved to be a critical functional group, essential for high potency and P450 selectivity.
Wensheng Xie +27 more
openaire +3 more sources
Journal of Molecular Catalysis B: Enzymatic, 2002
Abstract A study aimed to select efficient epoxide hydrolases (EHs) allowing to achieve the enzymatic resolution of 2-, 3- and 4-pyridyloxirane (1–3) has been achieved, using 2-pyridyloxirane 1 as test substrate. Five thus selected EH-sources that showed interesting enantioselectivity were looked at in more detail for the conversion of 1–3.
Roland Furstoss +4 more
openaire +2 more sources
Abstract A study aimed to select efficient epoxide hydrolases (EHs) allowing to achieve the enzymatic resolution of 2-, 3- and 4-pyridyloxirane (1–3) has been achieved, using 2-pyridyloxirane 1 as test substrate. Five thus selected EH-sources that showed interesting enantioselectivity were looked at in more detail for the conversion of 1–3.
Roland Furstoss +4 more
openaire +2 more sources
Journal of the Chemical Society, Perkin Transactions 1, 2000
A series of (±)-2,2-disubstituted oxiranes bearing an alkene or alkyne functional group were resolved by bacterial epoxide hydrolases with excellent selectivities. The presence of a carbon–carbon double or triple bond furnished a highly flexible system for substrate modification, which allowed the enantioselectivity to be tuned by rational substrate ...
Wolfgang Stampfer +2 more
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A series of (±)-2,2-disubstituted oxiranes bearing an alkene or alkyne functional group were resolved by bacterial epoxide hydrolases with excellent selectivities. The presence of a carbon–carbon double or triple bond furnished a highly flexible system for substrate modification, which allowed the enantioselectivity to be tuned by rational substrate ...
Wolfgang Stampfer +2 more
openaire +2 more sources
Dual Inhibitors of COX-2 and Soluble Epoxide Hydrolase (sEH)
Journal of Modern Medicinal Chemistry, 2013openaire +2 more sources
, 2012