Results 11 to 20 of about 8,971 (179)

Inhibition of soluble epoxide hydrolase is renoprotective in 5/6 nephrectomized Ren‐2 transgenic hypertensive rats [PDF]

Clinical and Experimental Pharmacology and Physiology, 2014
Summary The aim of the present study was to test the hypothesis that increasing kidney tissue concentrations of epoxyeicosatrienoic acids (EETs) by preventing their degradation to the biologically inactive dihydroxyeicosatrienoic acids (DHETEs) using blockade of soluble epoxide hydrolase (sEH) would attenuate the progression of chronic kidney disease
Petr Kujal, Věra Čertíková Chábová, Petra Škaroupková, Zuzana Husková, Z Vernerová, Herbert J. Kramer, Agnieszka Walkowska, Elżbieta Kompanowska‐Jezierska, Janusz Sadowski, Kento Kitada, Akira Nishiyama, Sung Hee Hwang, Bruce D. Hammock, John D. Imig, Luděk Červenka   +14 more
openalex   +6 more sources

Silencing of soluble epoxide hydrolase 2 gene reduces H₂O₂-induced oxidative damage in rat intestinal epithelial IEC-6 cells via activating PI3K/Akt/GSK3β signaling pathway. [PDF]

Cytotechnology, 2020
Li J, Luo J, Zhang Y, Tang C, Wang J, Chen C.   +5 more
europepmc   +3 more sources

A Long-Wavelength, Fluorogenic Probe for Epoxide Hydrolase: 7-(2-(Oxiran-2-yl)ethoxy) Resorufin

Biological and Pharmaceutical Bulletin, 2009
Epoxide hydrolase plays an important role in the detoxification of genotoxic compounds and in the control of physiological signaling molecules. Altered levels of epoxide hydrolase activity are associated with many diseases, such as emphysema, lung cancer, ovarian cancer, and laryngeal carcinoma. We designed and synthesized a resorufin-based fluorogenic
Wei Shen, Jiaming Zhang, Genjun Mao, Keyi Jiang, Qing Zhu   +4 more
openalex   +4 more sources

2-Oxaadamant-1-yl Ureas as Soluble Epoxide Hydrolase Inhibitors: In Vivo Evaluation in a Murine Model of Acute Pancreatitis [PDF]

Journal of Medicinal Chemistry, 2020
In vivo pharmacological inhibition of soluble epoxide hydrolase (sEH) reduces inflammatory diseases, including acute pancreatitis (AP). Adamantyl ureas are very potent sEH inhibitors, but the lipophilicity and metabolism of the adamantane group compromise their overall usefulness.
Sandra Codony, Eugènia Pujol, Javier Pizarro‐Delgado, Ferran Feixas, Elena Valverde, Marı́a Isabel Loza, José Brea, Elena Sáez, Julen Oyarzábal, António Pineda-Lucena, Belén Pérez, Concepción Pérez, María Isabel Rodríguez‐Franco, Rosana Leiva, Sílvia Osuna, Christophe Morisseau, Bruce D. Hammock, Manuel Vázquez‐Carrera, Santiago Vázquez   +18 more
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Elevation of hepatic microsomal epoxide hydrolase activity by 2-acetylaminofluorene: strain and species differences [PDF]

Carcinogenesis, 1984
Hepatocarcinogens have been shown to cause marked elevation of hepatic microsomal epoxide hydrolyase activity in the rat at short intervals after administration. The present studies were designed to characterize 2-acetylaminofluorene (AAF) mediated epoxide hydrolase elevation and to investigate the relationship between epoxide hydrolase increases, AAF ...
M. Elizabeth Graichen, John G. Dent
openalex   +5 more sources

Cytochrome P450-soluble epoxide hydrolase oxylipins, depression and cognition in type 2 diabetes

Journal of Diabetes and its Complications
This study examined serum cytochrome P450-soluble epoxide hydrolase (CYP450-sEH) oxylipins and depressive symptoms together in relation to cognitive performance in individuals with type 2 diabetes mellitus (T2DM).Clinically cognitively normal T2DM individuals were recruited (NCT04455867).
Natasha Z. Anita, Nathan Herrmann, Si Won Ryoo, Chelsi Major-Orfao, William Z. Lin, Felicia Kwan, Shiropa Noor, Jennifer S. Rabin, Susan Marzolini, Sean M. Nestor, Myuri Ruthirakuhan, Bradley J. MacIntosh, Maged Goubran, Pearl Yang, Hugo Cogo‐Moreira, Mark Rapoport, Damien Gallagher, Sandra E. Black, Benjamin I. Goldstein, Krista L. Lanctôt, Paul Oh, Ameer Y. Taha, Walter Swardfager   +22 more
openalex   +4 more sources

Inhibitory Activity of Quercetin 3-O-Arabinofuranoside and 2-Oxopomolic Acid Derived from Malus domestica on Soluble Epoxide Hydrolase [PDF]

Molecules, 2020
Flavonoids and triterpenoids were revealed to be the potential inhibitors on soluble epoxide hydrolase (sEH). The aim of this study is to reveal sEH inhibitors from Fuji apples.
In Sook Cho, Jang Hoon Kim, Yunjia Lin, Xiang Dong Su, Jong Seong Kang, Seo Young Yang, Young Ho Kim   +6 more
doaj   +2 more sources

Dual inhibition of cyclooxygenase-2 and soluble epoxide hydrolase synergistically suppresses primary tumor growth and metastasis [PDF]

Proceedings of the National Academy of Sciences, 2014
Significance Our study suggests that cyclooxygenase (COX)-2 and soluble epoxide hydrolase (sEH) pathways have potent synergistic antiangiogenic and anticancer activity. Dual pharmacological inhibition of COX-2 and sEH pathways may be useful in treating cancer with minimal toxicity associated with COX-2 inhibition.
Guodong Zhang, Dipak Panigrahy, Sung Hee Hwang, Jun Yang, Lisa M. Mahakian, Hiromi I. Wettersten, Jun‐Yan Liu, Yanru Wang, Elizabeth S. Ingham, Sarah Tam, Mark W. Kieran, Robert H. Weiss, Katherine W. Ferrara, Bruce D. Hammock   +13 more
openalex   +5 more sources

Microsomal epoxide hydrolase is not a 2-arachidonyl glycerol hydrolase [PDF]

Matters, 2016
Michael Arand, Anne Marowsky
openalex   +5 more sources

Epoxide hydrolase 2 (EPHX2; CEH) [PDF]

Science-Business eXchange, 2013
Barbara A. Boczar
  +7 more sources