Results 11 to 20 of about 11,381 (191)

Soluble Epoxide Hydrolase 2 Expression Is Elevated in Obese Humans and Decreased by Physical Activity. [PDF]

Int J Mol Sci, 2020
Epoxide hydrolase 2 (EPHX2) is an emerging therapeutic target in several immunometabolic disorders. EPHX2 metabolizes anti-inflammatory epoxyeicosatrienoic acids into pro-inflammatory diols. The contribution of EPHX2 activity to human obesity remains unexplored.
Khadir A, Kavalakatt S, Madhu D, Cherian P, Al-Mulla F, Abubaker J, Tiss A.   +6 more
europepmc   +6 more sources

Inhibition of Soluble Epoxide Hydrolase 2 Ameliorates Diabetic Keratopathy and Impaired Wound Healing in Mouse Corneas. [PDF]

Diabetes, 2018
EPHX2 (encoding soluble epoxide hydrolase [sEH]) converts biologically active epoxyeicosatrienoic acids (EETs), anti-inflammatory and profibrinolytic effectors, into the less biologically active metabolites, dihydroxyeicostrienoic acids. We sought to characterize the expression and the function of EPHX2 in diabetic corneas and during wound healing. The
Sun H, Lee P, Yan C, Gao N, Wang J, Fan X, Yu FS.   +6 more
europepmc   +5 more sources

Soluble epoxide hydrolase‐derived linoleic acid diols, cerebral small vessel disease markers and white matter microstructural integrity in type 2 diabetes mellitus [PDF]

Alzheimers Dement
Abstract Background While polyunsaturated fatty acids can be metabolized into beneficial, anti‐inflammatory epoxides, they are subsequently converted to inactive, cytotoxic diols by soluble epoxide hydrolase (sEH). Increased linoleic acid (LA)‐derived diols have been associated with poorer cognitive performance in type 2 diabetes mellitus (T2DM ...
Ryoo S, Lin W, Ruthirakuhan M, Wong Y, Anita N, Binns M, Montero‐Odasso M, Arnott S, Tartaglia C, Lang A, Symons S, Hegele R, MacIntosh B, Lanctôt K, Taha A, Black S, Swardfager W.   +16 more
europepmc   +4 more sources

Epoxide hydrolase 2 (EPHX2; CEH) [PDF]

Science-Business eXchange, 2013

  +7 more sources

Association of soluble epoxide hydrolase 2 gene with the risk of non-syndromic cleft lip with or without cleft palate in western Han Chinese population. [PDF]

Hua Xi Kou Qiang Yi Xue Za Zhi, 2022
Yang M, Wang Y, Yin B, Zheng Q, Shi B, Jia Z.   +5 more
europepmc   +3 more sources

Diabetic vascular calcification inhibited by soluble epoxide hydrolase gene deletion via regressing NID2-mediated IGF2-ERK1/2 signaling pathway [PDF]

Chinese Medical Journal
. Background:. Epoxyeicosatrienoic acids (EETs), which are metabolites of arachidonic acid catalyzed by cytochrome P450 epoxygenase, are degraded into inactive dihydroxyeicosatrienoic acids by soluble epoxide hydrolase (sEH).
Yueting Cai, Shuiqing Hu, Jingrui Liu, Jinlan Luo, Wenhua Li, Jiaxin Tang, Siyang Liu, Ruolan Dong, Yan Yang, Ling Tu, Xizhen Xu, Rongman Jia   +11 more
doaj   +2 more sources

Epoxide hydrolase 2 (EPHX2) [PDF]

Science-Business eXchange, 2009

openalex   +2 more sources

Silencing of soluble epoxide hydrolase 2 gene reduces H₂O₂-induced oxidative damage in rat intestinal epithelial IEC-6 cells via activating PI3K/Akt/GSK3β signaling pathway. [PDF]

Cytotechnology, 2020
Li J, Luo J, Zhang Y, Tang C, Wang J, Chen C.   +5 more
europepmc   +3 more sources

CYP4X1/sEH‐Dependent Endocannabinoid Metabolism Drives Fibroblast‐Mediated Immunosuppression to Limit Immunotherapy in Colon Cancer

Advanced Science
Cytochrome P450 (CYP) 4X1 and soluble epoxide hydrolase (sEH), the key enzymes responsible for endocannabinoid oxidative metabolism, have been implicated in inflammation and cancer.
Min Mo, Xuewei Chen, Yanzhuo Liu, Chenlong Wang, Xuehan Chen, Nan Zhang, Nan He, Ying Li, Jingyi Wang, Honglei Chen, Jing Yang   +10 more
doaj   +2 more sources

Dual Inhibitors of COX-2 and Soluble Epoxide Hydrolase (sEH)

Journal of Modern Medicinal Chemistry, 2013
Vijaykumar D. Nimbarte, Murtuza Hadianawala, Krishnam Raju Atcha   +2 more
  +5 more sources