Results 21 to 30 of about 11,381 (191)
Microsomal epoxide hydrolase is not a 2-arachidonyl glycerol hydrolase [PDF]
Matters, 2016 Michael Arand, Anne Marowsky
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A Long-Wavelength, Fluorogenic Probe for Epoxide Hydrolase: 7-(2-(Oxiran-2-yl)ethoxy) Resorufin
Biological and Pharmaceutical Bulletin, 2009 Epoxide hydrolase plays an important role in the detoxification of genotoxic compounds and in the control of physiological signaling molecules. Altered levels of epoxide hydrolase activity are associated with many diseases, such as emphysema, lung cancer, ovarian cancer, and laryngeal carcinoma. We designed and synthesized a resorufin-based fluorogenic
Wei Shen +4 more
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Organic Communications, 2023 Inhibition of soluble epoxide hydrolase (sEH) is implicated as a new therapeutic approach against inflammatory disorders in the context of metabolic and cardiovascular diseases. In the course of our ongoing research on sEH inhibitors, we synthesized novel piperidine/piperazine amide derivatives of the chromone-2-carboxylic acid, and evaluated their ...
Tuğçe Gür Maz, H. Burak Caliskan
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Dual inhibition of cyclooxygenase-2 and soluble epoxide hydrolase synergistically suppresses primary tumor growth and metastasis [PDF]
Proceedings of the National Academy of Sciences, 2014 SignificanceOur study suggests that cyclooxygenase (COX)-2 and soluble epoxide hydrolase (sEH) pathways have potent synergistic antiangiogenic and anticancer activity. Dual pharmacological inhibition of COX-2 and sEH pathways may be useful in treating cancer with minimal toxicity associated with COX-2 inhibition.
Guodong Zhang +13 more
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Physiological Reports, 2021 Oxylipins are metabolites of polyunsaturated fatty acids that mediate cardiovascular health by attenuation of inflammation, vascular tone, hemostasis, and thrombosis.
Rachel E. Walker +4 more
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Elevation of hepatic microsomal epoxide hydrolase activity by 2-acetylaminofluorene: strain and species differences [PDF]
Carcinogenesis, 1984 Hepatocarcinogens have been shown to cause marked elevation of hepatic microsomal epoxide hydrolyase activity in the rat at short intervals after administration. The present studies were designed to characterize 2-acetylaminofluorene (AAF) mediated epoxide hydrolase elevation and to investigate the relationship between epoxide hydrolase increases, AAF ...
M. Elizabeth Graichen, John G. Dent
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A novel ovary‐specific and ovulation‐associated variant of epoxide hydrolase 2 [PDF]
FEBS Letters, 2007 Ovulation is a complex process initiated by the surge of the pituitary luteinizing hormone (LH) that provokes the expression of specific genes. We report herein the isolation and characterization of an ovulation‐associated, ovary‐specific novel isoform of epoxide hydrolase 2 (Ephx2), Ephx2C.
Shkolnik, Ketty +4 more
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Frontiers in Pharmacology, 2020 Acute ischemic stroke is a serious disease that endangers human health. In our efforts to develop an effective therapy, we previously showed that the potent, highly selective inhibitor of soluble epoxide hydrolase called 1-trifuoromethoxyphenyl-3-(1 ...
Linlei Zhang +10 more
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Inhibitory Activity of Quaternary Isoquinoline Alkaloids on Soluble Epoxide Hydrolase
Current Issues in Molecular Biology, 2022 The quaternary isoquinoline alkaloids of palmatine (1), berberine (2), and jatrorrhizine (3) were evaluated in terms of their ability to inhibit soluble epoxide hydrolase (sEH). They had similar inhibitory activities, with IC50 values of 29.6 ± 0.5, 33.4
Jang Hoon Kim +8 more
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Maresin biosynthesis and identification of maresin 2, a new anti-inflammatory and pro-resolving mediator from human macrophages. [PDF]
PLoS ONE, 2014 Maresins are a new family of anti-inflammatory and pro-resolving lipid mediators biosynthesized from docosahexaenoic acid (DHA) by macrophages. Here we identified a novel pro-resolving product, 13R,14S-dihydroxy-docosahexaenoic acid (13R,14S-diHDHA ...
Bin Deng +6 more
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