Results 21 to 30 of about 8,971 (179)
Inhibiting the soluble epoxide hydrolase increases the EpFAs and ERK1/2 expression in the hippocampus of LiCl-pilocarpine post-status epilepticus rat model. [PDF]
IBRO Neurosci RepPeng W, Hu Z, Shen Y, Wang X.
europepmc +2 more sources
A novel ovary‐specific and ovulation‐associated variant of epoxide hydrolase 2 [PDF]
FEBS Letters, 2007 Ovulation is a complex process initiated by the surge of the pituitary luteinizing hormone (LH) that provokes the expression of specific genes. We report herein the isolation and characterization of an ovulation‐associated, ovary‐specific novel isoform of epoxide hydrolase 2 (Ephx2), Ephx2C.
Ketty Shkolnik +4 more
openaire +3 more sources
Physiological Reports, 2021 Oxylipins are metabolites of polyunsaturated fatty acids that mediate cardiovascular health by attenuation of inflammation, vascular tone, hemostasis, and thrombosis.
Rachel E. Walker +4 more
doaj +1 more source
Frontiers in Pharmacology, 2020 Acute ischemic stroke is a serious disease that endangers human health. In our efforts to develop an effective therapy, we previously showed that the potent, highly selective inhibitor of soluble epoxide hydrolase called 1-trifuoromethoxyphenyl-3-(1 ...
Linlei Zhang +10 more
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Maresin biosynthesis and identification of maresin 2, a new anti-inflammatory and pro-resolving mediator from human macrophages. [PDF]
PLoS ONE, 2014 Maresins are a new family of anti-inflammatory and pro-resolving lipid mediators biosynthesized from docosahexaenoic acid (DHA) by macrophages. Here we identified a novel pro-resolving product, 13R,14S-dihydroxy-docosahexaenoic acid (13R,14S-diHDHA ...
Bin Deng +6 more
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Journal of Enzyme Inhibition and Medicinal Chemistry, 2021 A novel compound 1 and nine known compounds (2–10) were isolated by open column chromatography analysis of the root bark of Ulmus davidiana. Pure compounds (1–10) were tested in vitro to determine the inhibitory activity of the catalytic reaction of ...
Jang Hoon Kim +5 more
doaj +1 more source
Inhibitory Activity of Quaternary Isoquinoline Alkaloids on Soluble Epoxide Hydrolase
Current Issues in Molecular Biology, 2022 The quaternary isoquinoline alkaloids of palmatine (1), berberine (2), and jatrorrhizine (3) were evaluated in terms of their ability to inhibit soluble epoxide hydrolase (sEH). They had similar inhibitory activities, with IC50 values of 29.6 ± 0.5, 33.4
Jang Hoon Kim +8 more
doaj +1 more source
Limonene-1,2-Epoxide Hydrolase from Rhodococcus erythropolis DCL14 Belongs to a Novel Class of Epoxide Hydrolases [PDF]
Journal of Bacteriology, 1998 ABSTRACT An epoxide hydrolase from Rhodococcus erythropolis DCL14 catalyzes the hydrolysis of limonene-1,2-epoxide to limonene-1,2-diol. The enzyme is induced when R. erythropolis is grown on monoterpenes, reflecting its role in the limonene degradation pathway of this microorganism.
van der Werf, M.J. +2 more
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mBio, 2016 Erythrocytes are reservoirs of important epoxide-containing lipid signaling molecules, including epoxyeicosatrienoic acids (EETs). EETs function as vasodilators and anti-inflammatory modulators in the bloodstream.
Natalie J. Spillman +2 more
doaj +1 more source