Results 21 to 30 of about 11,338 (171)

Combination of a UPO-Based Epoxidation With a Subsequent Ring-Opening Reaction for the Synthesis of Amino Alcohols. [PDF]

Chembiochem
The synthesis of aromatic amino alcohols via a combination of an unspecific peroxygenase‐catalysed reaction, oxyfunctionalization, and addition of selected nucleophiles and electrophiles in a highly atom‐efficient manner was investigated. This study presents the design to aim for an atom‐efficient chemo‐enzymatic synthesis route towards aromatic amino ...
Last S, Dietz N, Weissenborn MJ, von Langermann J.   +3 more
europepmc   +2 more sources

Diabetic vascular calcification inhibited by soluble epoxide hydrolase gene deletion via regressing NID2-mediated IGF2-ERK1/2 signaling pathway [PDF]

Chinese Medical Journal
. Background:. Epoxyeicosatrienoic acids (EETs), which are metabolites of arachidonic acid catalyzed by cytochrome P450 epoxygenase, are degraded into inactive dihydroxyeicosatrienoic acids by soluble epoxide hydrolase (sEH).
Yueting Cai, Shuiqing Hu, Jingrui Liu, Jinlan Luo, Wenhua Li, Jiaxin Tang, Siyang Liu, Ruolan Dong, Yan Yang, Ling Tu, Xizhen Xu, Rongman Jia   +11 more
doaj   +2 more sources

Soluble Epoxide Hydrolase 2 Expression Is Elevated in Obese Humans and Decreased by Physical Activity. [PDF]

Int J Mol Sci, 2020
Epoxide hydrolase 2 (EPHX2) is an emerging therapeutic target in several immunometabolic disorders. EPHX2 metabolizes anti-inflammatory epoxyeicosatrienoic acids into pro-inflammatory diols. The contribution of EPHX2 activity to human obesity remains unexplored.
Khadir A, Kavalakatt S, Madhu D, Cherian P, Al-Mulla F, Abubaker J, Tiss A.   +6 more
europepmc   +4 more sources

Regulation Roles of Juvenile Hormone Epoxide Hydrolase Gene 2 in the Female River Prawn Macrobrachium nipponense Reproductive Process

Current Issues in Molecular Biology
In this study, we investigated the regulatory roles of the juvenile hormone epoxide hydrolase (JHEH) gene in the reproductive process of female Macrobrachium nipponense. Its total cDNA length was 1848 bp, encoding for 460 amino acids.
Jisheng Wang, Mengying Zhang, Hongtuo Fu, Wenyi Zhang, Yiwei Xiong, Shubo Jin, Hui Qiao, Sufei Jiang   +7 more
doaj   +3 more sources

Inhibition of Soluble Epoxide Hydrolase 2 Ameliorates Diabetic Keratopathy and Impaired Wound Healing in Mouse Corneas. [PDF]

Diabetes, 2018
EPHX2 (encoding soluble epoxide hydrolase [sEH]) converts biologically active epoxyeicosatrienoic acids (EETs), anti-inflammatory and profibrinolytic effectors, into the less biologically active metabolites, dihydroxyeicostrienoic acids. We sought to characterize the expression and the function of EPHX2 in diabetic corneas and during wound healing. The
Sun H, Lee P, Yan C, Gao N, Wang J, Fan X, Yu FS.   +6 more
europepmc   +4 more sources

Effects of inflammation and soluble epoxide hydrolase inhibition on oxylipin composition of very low‐density lipoproteins in isolated perfused rat livers

Physiological Reports, 2021
Oxylipins are metabolites of polyunsaturated fatty acids that mediate cardiovascular health by attenuation of inflammation, vascular tone, hemostasis, and thrombosis.
Rachel E. Walker, Olga V. Savinova, Theresa L. Pedersen, John W. Newman, Gregory C. Shearer   +4 more
doaj   +1 more source

A novel ovary‐specific and ovulation‐associated variant of epoxide hydrolase 2 [PDF]

FEBS Letters, 2007
Ovulation is a complex process initiated by the surge of the pituitary luteinizing hormone (LH) that provokes the expression of specific genes. We report herein the isolation and characterization of an ovulation‐associated, ovary‐specific novel isoform of epoxide hydrolase 2 (Ephx2), Ephx2C.
Shkolnik, Ketty, Ben-Dor, Shifra, Galiani, Dalia, Hourvitz, Ariel, Dekel, Nava   +4 more
openaire   +2 more sources

Protective Effects of the Soluble Epoxide Hydrolase Inhibitor 1-Trifluoromethoxyphenyl-3-(1-Propionylpiperidin-4-yl) Urea in a Rat Model of Permanent Middle Cerebral Artery Occlusion

Frontiers in Pharmacology, 2020
Acute ischemic stroke is a serious disease that endangers human health. In our efforts to develop an effective therapy, we previously showed that the potent, highly selective inhibitor of soluble epoxide hydrolase called 1-trifuoromethoxyphenyl-3-(1 ...
Linlei Zhang, Linlei Zhang, Shasha Xu, Xiaoxiao Wu, Farah Mohamed Muse, Jiaou Chen, Yungang Cao, Jueyue Yan, Zicheng Cheng, Xingyang Yi, Zhao Han   +10 more
doaj   +1 more source

Inhibitory Activity of Quaternary Isoquinoline Alkaloids on Soluble Epoxide Hydrolase

Current Issues in Molecular Biology, 2022
The quaternary isoquinoline alkaloids of palmatine (1), berberine (2), and jatrorrhizine (3) were evaluated in terms of their ability to inhibit soluble epoxide hydrolase (sEH). They had similar inhibitory activities, with IC50 values of 29.6 ± 0.5, 33.4
Jang Hoon Kim, Chong Woon Cho, Mok Hur, Woo Tae Park, Youn-Ho Moon, Sung-Cheol Koo, Yun-Chan Hur, Jong Seong Kang, Ik Soo Lee   +8 more
doaj   +1 more source

Maresin biosynthesis and identification of maresin 2, a new anti-inflammatory and pro-resolving mediator from human macrophages. [PDF]

PLoS ONE, 2014
Maresins are a new family of anti-inflammatory and pro-resolving lipid mediators biosynthesized from docosahexaenoic acid (DHA) by macrophages. Here we identified a novel pro-resolving product, 13R,14S-dihydroxy-docosahexaenoic acid (13R,14S-diHDHA ...
Bin Deng, Chin-Wei Wang, Hildur H Arnardottir, Yongsheng Li, Chien-Yee Cindy Cheng, Jesmond Dalli, Charles N Serhan   +6 more
doaj   +1 more source