Results 31 to 40 of about 11,381 (191)

Total plasma cytochrome P450‐soluble epoxide hydrolase oxylipins, apolipoprotein E ε4 carrier status, and white matter hyperintensities in cerebrovascular disease [PDF]

Alzheimers Dement
Abstract Background The cytochrome P450‐soluble epoxide hydrolase (CYP450‐sEH) pathway has been implicated in cerebral small vessel disease (cSVD) due to the anti‐inflammatory and vasoactive effects of epoxide species produced by CYP450, which are converted into diols by sEH.
Lin W, Ryoo S, Magliocco A, Anita N, Ruthirakuhan M, Huang C, Perfetto S, Munoz D, Roberts A, Binns M, Lang A, Symons S, Taha A, Swardfager W.   +13 more
europepmc   +2 more sources

Inhibition of soluble epoxide hydrolase by phytochemical constituents of the root bark of Ulmus davidiana var. japonica

Journal of Enzyme Inhibition and Medicinal Chemistry, 2021
A novel compound 1 and nine known compounds (2–10) were isolated by open column chromatography analysis of the root bark of Ulmus davidiana. Pure compounds (1–10) were tested in vitro to determine the inhibitory activity of the catalytic reaction of ...
Jang Hoon Kim, Ji Su Park, Yun Ji Lee, Sena Choi, Young Ho Kim, Seo Young Yang   +5 more
doaj   +1 more source

Exported Epoxide Hydrolases Modulate Erythrocyte Vasoactive Lipids during Plasmodium falciparum Infection

mBio, 2016
Erythrocytes are reservoirs of important epoxide-containing lipid signaling molecules, including epoxyeicosatrienoic acids (EETs). EETs function as vasodilators and anti-inflammatory modulators in the bloodstream.
Natalie J. Spillman, Varun K. Dalmia, Daniel E. Goldberg   +2 more
doaj   +1 more source

Isolation of Two New Compounds and Other Constituents from Leaves of Piper crocatum and Study of Their Soluble Epoxide Hydrolase Activities

Molecules, 2019
Two new phenolic glucosides, pipercroside A and B (1 and 2), along with 10 known compounds were isolated from the leaves of Piper crocatum Ruiz & Pav.
Hong Xu Li, Seo Young Yang, Young Ho Kim, Wei Li   +3 more
doaj   +1 more source

Inhibitory activity of lignanamides isolated from hemp seed hulls(Cannabis sativa L.) against soluble epoxide hydrolase

Heliyon, 2023
Soluble epoxide hydrolase (sEH) is a therapeutic target for inflammation. In the present study, we isolated one new (1) and four known (2–5) compounds from the ethyl acetate fraction of hemp seed hulls.
Jang Hoon Kim, Yun-Chan Huh, Mok Hur, Woo Tae Park, Youn-Ho Moon, Tae IL. Kim, Seon Mi Kim, Sung-Cheol Koo   +7 more
doaj   +1 more source

Soluble Epoxide Hydrolase Inhibitory Activity of Components Isolated from Apios americana Medik

Molecules, 2017
A new compound 1, 5-methoxy-2,5,7,4′-tetrahydroxy-coumaronochromone, along with seven known compounds (2–8), were isolated from Apios americana using open column chromatography. Their structures were established based on an analysis of 1D and 2D NMR, and
Jang Hoon Kim, Hyo Young Kim, Si Yong Kang, Young Ho Kim, Chang Hyun Jin   +4 more
doaj   +1 more source

Inhibition of soluble epoxide hydrolase is renoprotective in 5/6 nephrectomized Ren‐2 transgenic hypertensive rats [PDF]

Clinical and Experimental Pharmacology and Physiology, 2014
Summary The aim of the present study was to test the hypothesis that increasing kidney tissue concentrations of epoxyeicosatrienoic acids (EETs) by preventing their degradation to the biologically inactive dihydroxyeicosatrienoic acids (DHETEs) using blockade of soluble epoxide hydrolase (sEH) would attenuate the progression of chronic kidney disease
Kujal, Petr, Chábová, Vera Čertíková, Škaroupková, Petra, Husková, Zuzana, Vernerová, Zdena, Kramer, Herbert J, Walkowska, Agnieszka, Kompanowska-Jezierska, Elzbieta, Sadowski, Janusz, Kitada, Kento, Nishiyama, Akira, Hwang, Sung H, Hammock, Bruce D, Imig, John D, Červenka, Ludek   +14 more
openaire   +4 more sources

Preclinical evaluation of EPHX2 inhibition as a novel treatment for inflammatory bowel disease.

PLoS ONE, 2019
Epoxyeicosatrienoic acids (EETs) are signaling lipids produced by cytochrome P450 epoxygenation of arachidonic acid, which are metabolized by EPHX2 (epoxide hydrolase 2, alias soluble epoxide hydrolase or sEH).
William C Reisdorf, Qing Xie, Xin Zeng, Wensheng Xie, Neetu Rajpal, Bao Hoang, Mark E Burgert, Vinod Kumar, Mark R Hurle, Deepak K Rajpal, Sarah O'Donnell, Thomas T MacDonald, Anna Vossenkämper, Lin Wang, Mike Reilly, Bart J Votta, Yolanda Sanchez, Pankaj Agarwal   +17 more
doaj   +1 more source

Soluble epoxide hydrolase in the human placenta throughout gestation

Taiwanese Journal of Obstetrics & Gynecology, 2019
Objective: To investigate the spatial and temporal changes of soluble epoxide hydrolase (sEH) in the human placenta throughout gestation and to study the effects of hypoxia-reoxygenation (HR) on the expression of sEH in villous explants in vitro ...
Tai-Ho Hung, Szu-Fu Chen, T'sang-T'ang Hsieh   +2 more
doaj   +1 more source

Altered bioavailability of epoxyeicosatrienoic acids is associated with conduit artery endothelial dysfunction in type 2 diabetic patients

Cardiovascular Diabetology, 2019
Background This pathophysiological study addressed the hypothesis that soluble epoxide hydrolase (sEH), which metabolizes the vasodilator and anti-inflammatory epoxyeicosatrienoic acids (EETs) to dihydroxyeicosatrienoic acids (DHETs), contributes to ...
Thomas Duflot, Lucile Moreau-Grangé, Clothilde Roche, Michèle Iacob, Julien Wils, Isabelle Rémy-Jouet, Anne-Françoise Cailleux, Matthieu Leuillier, Sylvanie Renet, Dongyang Li, Christophe Morisseau, Fabien Lamoureux, Vincent Richard, Gaëtan Prévost, Robinson Joannidès, Jérémy Bellien   +15 more
doaj   +1 more source