Results 41 to 50 of about 11,381 (191)

ZDHXB-101 (3′,5-Diallyl-2, 4′-dihydroxy-[1,1′-biphen-yl]-3,5′-dicarbaldehyde) protects against airway remodeling and hyperresponsiveness via inhibiting both the activation of the mitogen-activated protein kinase and the signal transducer and activator of transcription-3 signaling pathways

Respiratory Research, 2020
Airway remodeling consists of the structural changes of airway walls, which is often considered the result of longstanding airway inflammation, but it may be present to an equivalent degree in the airways of children with asthma, raising the need for ...
Jun-xia Jiang, Hui-juan Shen, Yan Guan, Yong-liang Jia, Jian Shen, Qi Liu, Qiang-min Xie, Xiao-feng Yan   +7 more
doaj   +1 more source

Bioactive Hydroperoxyl Cembranoids from the Red Sea Soft Coral Sarcophyton glaucum

Marine Drugs, 2012
A chemical investigation of an ethyl acetate extract of the Red Sea soft coral Sarcophyton glaucum has led to the isolation of two peroxide diterpenes, 11(S) hydroperoxylsarcoph-12(20)-ene (1), and 12(S)-hydroperoxylsarcoph-10-ene (2), as well as 8-epi ...
Abdelaaty A. Shahat, Bruce R. Whittlesey, Paul W. Paré, Fathy F. Abdel-Latif, Tarik A. Mohamed, Mohamed-Elamir F. Hegazy, Amira M. Gamal Eldeen   +6 more
doaj   +1 more source

CES2 sustains HNF4α expression to promote pancreatic adenocarcinoma progression through an epoxide hydrolase-dependent regulatory loop

Molecular Metabolism, 2022
Objective: Intra-tumoral expression of the serine hydrolase carboxylesterase 2 (CES2) contributes to the activation of the pro-drug irinotecan in pancreatic ductal adenocarcinoma (PDAC).
Yihui Chen, Michela Capello, Mayrim V. Rios Perez, Jody V. Vykoukal, David Roife, Ya'an Kang, Laura R. Prakash, Hiroyuki Katayama, Ehsan Irajizad, Alia Fleury, Sammy Ferri-Borgogno, Dodge L. Baluya, Jennifer B. Dennison, Kim-Anh Do, Oliver Fiehn, Anirban Maitra, Huamin Wang, Paul J. Chiao, Matthew H.G. Katz, Jason B. Fleming, Samir M. Hanash, Johannes F. Fahrmann   +21 more
doaj   +1 more source

Cytochrome P450-soluble epoxide hydrolase oxylipins, depression and cognition in type 2 diabetes

Journal of Diabetes and its Complications
This study examined serum cytochrome P450-soluble epoxide hydrolase (CYP450-sEH) oxylipins and depressive symptoms together in relation to cognitive performance in individuals with type 2 diabetes mellitus (T2DM).Clinically cognitively normal T2DM individuals were recruited (NCT04455867).
Natasha Z. Anita, Nathan Herrmann, Si Won Ryoo, Chelsi Major-Orfao, William Z. Lin, Felicia Kwan, Shiropa Noor, Jennifer S. Rabin, Susan Marzolini, Sean M. Nestor, Myuri Ruthirakuhan, Bradley J. MacIntosh, Maged Goubran, Pearl Yang, Hugo Cogo‐Moreira, Mark Rapoport, Damien Gallagher, Sandra E. Black, Benjamin I. Goldstein, Krista L. Lanctôt, Paul Oh, Ameer Y. Taha, Walter Swardfager   +22 more
openalex   +4 more sources

A genome-wide association study identified one variant associated with static spatial working memory in Chinese population

Frontiers in Genetics, 2022
Spatial working memory (SWM) is a kind of memory that temporarily preserves spatial information (the location or order of objects, etc.). Individuals with mental disorders tend to show worse performance in SWM task.
Liming Zhang, Zijian Zhu, Qing Yang, Jingjing Zhao   +3 more
doaj   +1 more source

Human exposure to diesel exhaust induces CYP1A1 expression and AhR activation without a coordinated antioxidant response

Particle and Fibre Toxicology, 2023
Background Diesel exhaust (DE) induces neutrophilia and lymphocytosis in experimentally exposed humans. These responses occur in parallel to nuclear migration of NF-κB and c-Jun, activation of mitogen activated protein kinases and increased production of
M. Friberg, A. F. Behndig, J. A. Bosson, Ala Muala, S. Barath, R. Dove, D. Glencross, F. J. Kelly, A. Blomberg, I. S. Mudway, T. Sandström, J. Pourazar   +11 more
doaj   +1 more source

Regulation of Juvenile Hormone on Summer Diapause of Geleruca daurica and Its Pathway Analysis

Insects, 2021
Juvenile hormone (JH) signaling plays an important role in regulation of reproductive diapause in insects. However, we have little understanding of the effect of JH on gene expression at the transcriptome level in diapause. Galeruca daurica is a new pest
Hong-Yue Ma, Yan-Yan Li, Ling Li, Yao Tan, Bao-Ping Pang   +4 more
doaj   +1 more source

Structural Modifications Yield Novel Insights Into the Intriguing Pharmacodynamic Potential of Anti-inflammatory Nitro-Fatty Acids

Frontiers in Pharmacology, 2021
Endogenous nitro-fatty acids (NFA) are potent electrophilic lipid mediators that exert biological effects in vitro and in vivo via selective covalent modification of thiol-containing target proteins.
Nadine Hellmuth, Camilla Brat, Omar Awad, Omar Awad, Sven George, Astrid Kahnt, Tom Bauer, Hai Phong Huynh Phuoc, Dieter Steinhilber, Carlo Angioni, Mohamed Hassan, Mohamed Hassan, Katharina J. Hock, Georg Manolikakes, Kai Zacharowski, Jessica Roos, Jessica Roos, Thorsten J. Maier, Thorsten J. Maier   +18 more
doaj   +1 more source

A Quantum Framework for Protein Binding‐Site Structure Prediction on Utility‐Level Quantum Processors

Advanced Science, EarlyView.
This study presents a hybrid quantum‐classical framework for accurate prediction of protein structures on utility‐level quantum processors. We evaluate the practical application of the Variational Quantum Eigen‐solver (VQE) in protein structure prediction and demonstrate its superiority over state‐of‐the‐art deep learning methods in molecular docking ...
Yuqi Zhang, Yuxin Yang, William Martin, Kingsten Lin, Zixu Wang, Cheng‐Chang Lu, Weiwen Jiang, Ruth Nussinov, Joseph Loscalzo, Qiang Guan, Feixiong Cheng   +10 more
wiley   +1 more source

Effect Of Dual sEH/COX-2 Inhibition on Allergen-Induced Airway Inflammation

Frontiers in Pharmacology, 2019
Arachidonic acid metabolites resulting from the cyclooxygenase (COX), lipoxygenase, and cytochrome P450 oxidase enzymatic pathways play pro- and anti-inflammatory roles in allergic airway inflammation (AAI) and asthma.
Mythili Dileepan, Stephanie Rastle-Simpson, Yana Greenberg, Dayanjan S. Wijesinghe, Naren Gajenthra Kumar, Jun Yang, Sung Hee Hwang, Bruce D. Hammock, P. Sriramarao, Savita P. Rao   +9 more
doaj   +1 more source