Results 41 to 50 of about 8,971 (179)

A genome-wide association study identified one variant associated with static spatial working memory in Chinese population

Frontiers in Genetics, 2022
Spatial working memory (SWM) is a kind of memory that temporarily preserves spatial information (the location or order of objects, etc.). Individuals with mental disorders tend to show worse performance in SWM task.
Liming Zhang, Zijian Zhu, Qing Yang, Jingjing Zhao   +3 more
doaj   +1 more source

Integrative Analysis of Methylation and Copy Number Variations of Prostate Adenocarcinoma Based on Weighted Gene Co-expression Network Analysis

Frontiers in Oncology, 2021
Prostate adenocarcinoma (PRAD) is the most pervasive carcinoma diagnosed in men with over 170,000 new cases every year in the United States and is the second leading cause of death from cancer in men despite its indolent clinical course.
Yaxin Hou, Yaxin Hou, Junyi Hu, Junyi Hu, Lijie Zhou, Lijie Zhou, Lilong Liu, Lilong Liu, Ke Chen, Ke Chen, Xiong Yang   +10 more
doaj   +1 more source

Acetylation‐Deacetylation‐Driven Natural Product Biosynthesis

ChemistryEurope, EarlyView.
This review summarizes the role of acetylation‐deacetylation in natural product biosynthesis, including acetylation followed by deacetylation after several biosynthetic steps, acetylation‐mediated rearrangement, acetylation‐triggered elimination, and the acetylation cycle as a regulatory mechanism. These processes are vital for the formation of complex
Huibin Wang, Ikuro Abe
wiley   +1 more source

Epoxide Hydrolase‐Catalyzed Enantioselective Synthesis of Chiral 1,2‐Diols via Desymmetrization of meso‐Epoxides. [PDF]

ChemInform, 2004
AbstractFor Abstract see ChemInform Abstract in Full Text.
Lishan Zhao, David P. Weiner, Mark J. Burk, et al. et al.   +3 more
openaire   +2 more sources

Engineering of the Thiamine Diphosphate‐Dependent JanthE for the Synthesis of Tertiary Alcohols

Chemistry – A European Journal, EarlyView.
The synthesis of chiral tertiary alcohols is in high demand. Here we investigate in detail the aldehyde–ketone cross‐coupling reactions catalyzed by the promising thiamine diphosphate‐dependent lyase JanthE. Focusing on both reaction parameters and engineering, we rationally develop JanthE to improve its applicability and demonstrate its evolvability ...
Lucrezia Lanza, Daniela Bjarnesen, Mehmet Mervan Çakar, Andrea Rizzo, Akash Pandya, Carmen Aranda, Zvjezdana Findrik Blažević, Michael Müller   +7 more
wiley   +1 more source

The effect of deep eutectic solvents on the asymmetric hydrolysis of styrene oxide by mung bean epoxide hydrolases

Bioresources and Bioprocessing, 2018
Background Deep eutectic solvents have attracted considerable attention in numerous fields. There is little information on mung bean epoxide hydrolase-catalyzed epoxides in deep eutectic solvent-containing system.
Fei Peng, Ying Zhao, Fang-Zhou Li, Min-Hua Zong, Wen-Yong Lou   +4 more
doaj   +1 more source

Inhibitory Activity of Flavonoids, Chrysoeriol and Luteolin-7-O-Glucopyranoside, on Soluble Epoxide Hydrolase from Capsicum chinense

Biomolecules, 2020
Three flavonoids derived from the leaves of Capsicum chinense Jacq. were identified as chrysoeriol (1), luteolin-7-O-glucopyranoside (2), and isorhamnetin-7-O-glucopyranoside (3).
Jang Hoon Kim, Chang Hyun Jin
doaj   +1 more source

Changes in Protein Expression of Renal Drug Transporters and Drug‐Metabolizing Enzymes in Autosomal Dominant Polycystic Kidney Disease Patients

Clinical Pharmacology &Therapeutics, EarlyView.
Autosomal dominant polycystic kidney disease is the most prevalent inherited kidney disease and leads to bilateral kidney enlargement and progressive loss of renal function, often over decades. Comorbidities include hypertension, flank pain, and bacterial infections. The condition often necessitates prolonged multidrug therapy.
Annika C. Tillmann, Dorien J. M. Peters, Amin Rostami‐Hodjegan, Patricia Wilson, Jill Norman, Jill Barber, Zubida M. Al‐Majdoub   +6 more
wiley   +1 more source

Species Differences in Metabolism of Soluble Epoxide Hydrolase Inhibitor, EC1728, Highlight the Importance of Clinically Relevant Screening Mechanisms in Drug Development

Molecules, 2021
There are few novel therapeutic options available for companion animals, and medications rely heavily on repurposed drugs developed for other species.
Cindy B. McReynolds, Jun Yang, Alonso Guedes, Christophe Morisseau, Roberto Garcia, Heather Knych, Caitlin Tearney, Briana Hamamoto, Sung Hee Hwang, Karen Wagner, Bruce D. Hammock   +10 more
doaj   +1 more source

Synthesis of 19‐Hydroxyarachidonic Acid by Fungal Peroxygenases: An Experimental and Computational Study

ChemSusChem, Accepted Article.
Hydroxylated derivatives of arachidonic acid play crucial roles in physiology and inflammation response, with distinct biological effects for (R)‐ and (S)‐enantiomers, highlighting their pharmaceutical relevance. Here, we harness recombinant unspecific peroxygenases (UPOs)—from the fungi Coprinopsis cinerea (rCciUPO) and Agrocybe aegerita (rAaeUPO ...
Alejandro González-Benjumea, Mireia Martínez-Sugrañes, Miguel Alcalde, Elvira Romero, Víctor Guallar, Martin Floor, Angel T. Martínez, Ana Gutiérrez   +7 more
wiley   +1 more source