Results 51 to 60 of about 11,381 (191)

Development of Dimethylsulfonium Probes for Broad Profiling of Methyllysine Reader Proteins

Advanced Science, EarlyView.
Development of oligoglycine‐based dimethylsulfonium probes for unbiased crosslinking to methyllysine readers. The general probe facilitates profiling of site‐specific methyllysine readers, evaluation of selectivity and activity of reader inhibitors, and global profiling of methyllysine readers.
Jinyu Yang, Yihang Xiao, Yingxiao Gao, Mingxuan Wu   +3 more
wiley   +1 more source

In Vitro and In Silico Insights into sEH Inhibitors with Amide-Scaffold from the Leaves of Capsicum chinense Jacq.

Computational and Structural Biotechnology Journal, 2018
Two compounds termed 1 and 2 were isolated from the leaves of Capsicum chinense using column chromatography. Their structures were identified as amide scaffolds by analyzing spectroscopic signals.
Jang Hoon Kim, Yeong Deuk Jo, Hyo-Young Kim, Bo-Ram Kim, Bomi Nam   +4 more
doaj   +1 more source

Anti-inflammatory of disenecionyl cis-khellactone in LPS-stimulated RAW264.7 cells and the its inhibitory activity on soluble epoxide hydrolase

Heliyon, 2023
The objective of the present study was to investigate anti-inflammatory effects of disenecionyl cis-khellactone (DK) isolated from Peucedanum japonicum Thunberg, a traditional edible plant, in RAW264.7 cells stimulated with lipopolysaccharide (LPS). Anti-
Ji Hyeon Park, Jang Hoon Kim, Seon Il Jang, Byoung Ok Cho   +3 more
doaj   +1 more source

Bioinformatics‐based discovery of the involvement of PSAT1 in mediating the anti‐lung adenocarcinoma activity of triptolide

Animal Models and Experimental Medicine, EarlyView.
Transcriptome sequencing was performed on tumor tissues from triptolide‐treated tumor‐bearing mice. The sequencing results were integrated with data from public databases for comprehensive analysis, and potential regulatory targets of triptolide were identified.
Zhiwen Cao, Lulu Zhang, Wenqiang Zhang, Rong Wan, Xiaogang Peng, Jinyan Xie, Ruru Bai, Jiejing Jin, Changqi Shi, Lan Yan, Xiangyu Guo, Yang Shen, Cheng Lu   +12 more
wiley   +1 more source

Integrative Analysis of Methylation and Copy Number Variations of Prostate Adenocarcinoma Based on Weighted Gene Co-expression Network Analysis

Frontiers in Oncology, 2021
Prostate adenocarcinoma (PRAD) is the most pervasive carcinoma diagnosed in men with over 170,000 new cases every year in the United States and is the second leading cause of death from cancer in men despite its indolent clinical course.
Yaxin Hou, Yaxin Hou, Junyi Hu, Junyi Hu, Lijie Zhou, Lijie Zhou, Lilong Liu, Lilong Liu, Ke Chen, Ke Chen, Xiong Yang   +10 more
doaj   +1 more source

Parkinson's‐Linked LRRK2 and GBA1 Mutations Modulate the Peripheral Immune Response to Pseudomonas aeruginosa

Movement Disorders, EarlyView.
Abstract Background Peripheral disease mechanisms such as immune dysregulation may contribute to Parkinson's disease (PD). To investigate interactions between common PD mutations and immune responses to environmental pathogens, we studied responses to Pseudomonas aeruginosa (P.
Julian R. Mark, Hannah A. Staley, Ann M. Titus, Julian Agin‐Liebes, Alicia Garrido, Laura Hughes, Nicolas Dzamko, Rebecca L. Wallings, Malú Gámez Tansey   +8 more
wiley   +1 more source

The effect of deep eutectic solvents on the asymmetric hydrolysis of styrene oxide by mung bean epoxide hydrolases

Bioresources and Bioprocessing, 2018
Background Deep eutectic solvents have attracted considerable attention in numerous fields. There is little information on mung bean epoxide hydrolase-catalyzed epoxides in deep eutectic solvent-containing system.
Fei Peng, Ying Zhao, Fang-Zhou Li, Min-Hua Zong, Wen-Yong Lou   +4 more
doaj   +1 more source

Human genetics and real‐world patient data fuel target and drug discovery in Alzheimer's disease using Artificial Intelligence [PDF]

Alzheimers Dement
Abstract Background Although high‐throughput DNA/RNA sequencing technologies from the NIA‐funded Alzheimer's disease sequencing project (ADSP) have generated massive genetic and genomic data in human disease, translation of these findings into new patient treatment has not materialized by lack of effective approaches, such as Artificial Intelligence ...
Cheng F, Hou Y, Pieper A, Haines J, Cummings J.   +4 more
europepmc   +2 more sources

D‐Optimal Design for Enzymatic Ring‐Opening Polymerization of ε‐Caprolactone: Toward Sustainable Polyester Synthesis Using Biobased Solvents

Journal of Polymer Science, EarlyView.
A D‐optimal design of experiments maps the influence of key reaction parameters on enzymatic ε‐caprolactone polymerization. Thus linking multivariate conditions to conversion, molar mass characteristics, and by‐product formation, whilst demonstrating that biobased solvents offer viable, sustainable media for polyester synthesis.
Emily G. Dixon, Emily Chau, Luisa Ciano, Anca Pordea, Karen Alvey, Vincenzo Taresco   +5 more
wiley   +1 more source

Bioresolution Production of (2R,3S)-Ethyl-3-phenylglycidate for Chemoenzymatic Synthesis of the Taxol C-13 Side Chain by Galactomyces geotrichum ZJUTZQ200, a New Epoxide-Hydrolase-Producing Strain

Molecules, 2014
A newly isolated Galactomyces geotrichum ZJUTZQ200 strain containing an epoxide hydrolase was used to resolve racemic ethyl 3-phenylglycidate (rac-EPG) for producing (2R,3S)-ethyl-3-phenylglycidate ((2R,3S)-EPG). G.
Chun Wei, Jinlong Ling, Honglei Shen, Qing Zhu   +3 more
doaj   +1 more source