Results 71 to 80 of about 11,381 (191)

Fasting and postprandial soluble epoxide hydrolase-associated eicosanoids of remitted patients with eating disorder

Data in Brief, 2018
Food aversion and food avoidance are significant challenges to overcome for patients with eating disorder such as anorexia nervosa. The epoxide hydrolase 2 gene (EPXH2) has been uncovered as a novel anorexia nervosa risk gene.
Jun Yang, Pei-an Betty Shih
doaj   +1 more source

GMPPB‐CDG Results in Lysosomal Dysfunction and Acid Alpha‐Glucosidase Deficiency

Journal of Inherited Metabolic Disease, Volume 49, Issue 1, January 2026.
ABSTRACT GDP‐mannose pyrophosphorylase B (GMPPB) deficiency is a congenital disorder of glycosylation due to pathogenic variants of the GMPPB gene. GMPPB catalyzes GDP‐mannose synthesis, an early step in multiple glycosylation pathways, including N‐glycosylation, O‐mannosylation, C‐mannosylation, and glycosylphosphatidylinositol‐anchor formation.
Carla Damiano, Antonietta Tarallo, Vincenza Gragnaniello, Sandra Strollo, Simona Fecarotta, M. Rosaria Tuzzi, Elena Polishchuk, Sandro Montefusco, Anna Valanzano, Antonia Assunto, Nadia Minopoli, Roberto Della Casa, Roman Polishchuk, Stijn L. M. in 't Groen, Diego Luis Medina, Enrico Bertini, Rosalba Carrozzo, Julia Emmerich, Benedikt Schoser, W. W. M. Pim Pijnappel, Giancarlo Parenti   +20 more
wiley   +1 more source

Arabidopsis root lipid droplets are hubs for membrane homeostasis under heat stress, and triterpenoid synthesis and storage

New Phytologist, Volume 249, Issue 2, Page 892-916, January 2026.
Summary Plant lipid droplets (LDs) and their associated proteins have numerous subcellular and physiological functions. While considerable progress has been made for LDs in many tissues, the function and composition of LDs in roots remain largely unexplored.
Patricia Scholz, Janis Dabisch, Ana C. Vilchez, Alyssa C. Clews, Philipp W. Niemeyer, Magdiel S. S. Lim, Siqi Sun, Lea Hembach, Mayuko Naganawa, Fabienne Dreier, Katharina F. Blersch, Lea M. Preuß, Martin Bonin, Elena Lesch, Yuya Iwai, Takashi L. Shimada, Jürgen Eirich, Iris Finkemeier, Katharina Gutbrod, Peter Dörmann, You Wang, Robert T. Mullen, Till Ischebeck   +22 more
wiley   +1 more source

Microvascular Health as a Key Determinant of Organismal Aging

Advanced Science, Volume 12, Issue 47, December 18, 2025.
Abstract Aging is a complex, multifaceted process affecting all organ systems, with vascular aging playing a central role in organismal health decline. Beyond its role in circulation, the vascular system acts as a dynamic interface between tissues, influencing countless physiological functions such as tissue regeneration and repair, immune responses ...
Mattia Cenciarini, Andrea Uccelli, Francesca Mangili, Myriam Grunewald, Simone Bersini   +4 more
wiley   +1 more source

Soluble epoxide hydrolase inhibitor improves cardiac ischemic tolerance in Ren‐2 transgenic rats

The FASEB Journal, 2008
Arachidonic acid metabolites of the cytochrome P450 epoxygenase pathway, the epoxyeicosatrienoic acids (EETs), have been shown to protect hearts against ischemia/reperfusion injury. Here, we examined effects of inhibition of the EETs‐degrading enzyme, soluble epoxide hydrolase (sEH), on cardiac ischemic tolerance in hypertensive ...
Jan Neckar, Ludek Cervenka, Bruce D Hammock, Sung H Hwang, John D Imig, Frantisek Kolar   +5 more
openaire   +1 more source

Missense Genetic Polymorphisms of Microsomal (EPHX1) and Soluble Epoxide Hydrolase (EPHX2) and Their Relation to the Risk of Large Artery Atherosclerotic Ischemic Stroke in a Turkish Population

Neuropsychiatric Disease and Treatment, 2021
Birsen Can Demirdöğen,1 Yağmur Miçooğulları,2 Aysun Türkanoğlu Özçelik,3 Orhan Adalı4 1Department of Biomedical Engineering, TOBB University of Economics and Technology, Ankara, Turkey; 2Institute of Natural and Applied ...
Can Demirdöğen B, Miçooğulları Y, Türkanoğlu Özçelik A, Adalı O   +3 more
doaj  

The Role and Therapeutic Potential of the cGAS‐STING Signaling Pathway in Alzheimer's Disease

Brain and Behavior, Volume 15, Issue 12, December 2025.
This work reveals the relationship between the cGAS‐STING signaling pathway and the pathological mechanisms of Alzheimer's disease.The role of the cGAS‐STING signaling pathway in AD pathology. AD leads to the production of neutrophil extracellular traps (NETs), endoplasmic reticulum (ER) stress, and the release of mitochondrial DNA (mtDNA) and nuclear ...
Xue Li, Wei Gao, Qiuyan Ye, Honglin Li
wiley   +1 more source

Author response for "Inhibition of soluble epoxide hydrolase (sEH) protects hippocampal neurons and reduces cognitive decline in type 2 diabetic mice"

, 2020
Jing Wu, Zhen Fan, Yuxing Zhao, Qiunan Chen, Qian Xiao   +4 more
openalex   +2 more sources

Exploring the Antiangiogenic and Anti-Inflammatory Potential of Homoisoflavonoids: Target Identification Using Biotin Probes

Biomolecules
Chemical proteomics using biotin probes of natural products have significantly advanced our understanding of molecular targets and therapeutic potential.
Xiang Fei, Sangil Kwon, Jinyoung Jang, Minyoung Seo, Seongwon Yu, Timothy W. Corson, Seung-Yong Seo   +6 more
doaj   +1 more source

A Novel Dual Soluble Epoxide Hydrolase Inhibitor/Cyclooxygenase‐2 Inhibitor Treats Type 2 Diabetic Complications in Obese ZSF1 Rats

The FASEB Journal, 2019
Diabetes is a highly prevalent chronic disease worldwide that represents a global healthcare burden. A devastating type 2 diabetes complication is diabetic nephropathy. We developed a novel dual modulator, PTUPB that concurrently acts as a soluble epoxide hydrolase (sEH) inhibitor as well as a cyclooxyganse‐2 inhibitor (sEHi/COXi ...
Abdul Hye Khan, Lauren Kolb, Melissa Skibba, Michael M Yeboah, Marla A Chesnik, Sung H Hwang, Bruce D Hammock, John D Imig   +7 more
openaire   +1 more source