Results 81 to 90 of about 11,381 (191)

Review for "Inhibition of soluble epoxide hydrolase (sEH) protects hippocampal neurons and reduces cognitive decline in type 2 diabetic mice"

, 2021
Baruh Polis
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Role of CYP2C9, CYP2C19 and EPHX Polymorphism in the Pharmacokinetic of Phenytoin: A Study on Uruguayan Caucasian Subjects

Pharmaceuticals, 2017
Phenytoin (PHT) oxidative route leads to its main metabolite p-hydroxyphenytoin (p-HPPH), by means of CYP2C9 and CYP2C19. Formation of p-HPPH proceeds via a reactive arene-oxide intermediate.
Natalia Guevara, Cecilia Maldonado, Manuel Uría, Raquel González, Manuel Ibarra, Silvana Alvariza, Antonella Carozzi, Carlos Azambuja, Pietro Fagiolino, Marta Vázquez   +9 more
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Active maintenance of endothelial cells prevents kidney fibrosis

Kidney Research and Clinical Practice, 2017
Background: Soluble epoxide hydrolase (sEH) expressed by endothelial cells catalyzes the metabolism of epoxyeicosatrienoic acids (EETs), which are vasoactive agents.
Seung Hee Yang, Yong Chul Kim, Jung Nam An, Jin Hyuk Kim, Juhoh Lee, Hee-Yoon Lee, Joo-Youn Cho, Jin Ho Paik, Yun Kyu Oh, Chun Soo Lim, Yon Su Kim, Jung Pyo Lee   +11 more
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Epoxyeicosatrienoic acid (EET)-stimulated angiogenesis is mediated by epoxy hydroxyeicosatrienoic acids (EHETs) formed from COX-2

Journal of Lipid Research, 2019
Epoxyeicosatrienoic acids (EETs) are formed from the metabolism of arachidonic acid by cytochrome P450s. EETs promote angiogenesis linked to tumor growth in various cancer models that is attenuated in vivo by cyclooxygenase 2 (COX-2) inhibitors.
Amy A. Rand, Anita Rajamani, Sean D. Kodani, Todd R. Harris, Lukas Schlatt, Bodgan Barnych, Anthony G. Passerini, Bruce D. Hammock   +7 more
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Redox Regulation of Soluble Epoxide Hydrolase by 15-Deoxy-Δ-Prostaglandin J ₂ Controls Coronary Hypoxic Vasodilation [PDF]

, 2010
Rebecca L. Charles, Joseph R. Burgoyne, Manuel Mayr, Steven M. Weldon, Norbert Hübner, Hua Dong, Christophe Morisseau, Bruce D. Hammock, Aimee Landar, Philip Eaton   +9 more
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Soluble Epoxide Hydrolase Inhibition Protected against Angiotensin II-induced Adventitial Remodeling

Scientific Reports, 2017
Epoxyeicosatrienoic acids (EETs), the metabolites of cytochrome P450 epoxygenases derived from arachidonic acid, exert important biological activities in maintaining cardiovascular homeostasis.
Chi Zhou, Jin Huang, Qing Li, Jiali Nie, Xizhen Xu, Dao Wen Wang   +5 more
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Combined Inhibition of Soluble Epoxide Hydrolase and Renin-Angiotensin System Exhibits Superior Renoprotection to Renin-Angiotensin System Blockade in 5/6 Nephrectomized Ren-2 Transgenic Hypertensive Rats with Established Chronic Kidney Disease [PDF]

, 2018
Věra Čertíková Chábová, Petr Kujal, Petra Škaroupková, Zdeňka Varňourková, Šárka Vacková, Zuzana Husková, Soňa Kikerlová, Janusz Sadowski, Elżbieta Kompanowska‐Jezierska, Iwona Baranowska, Sung Hee Hwang, Bruce D. Hammock, John D. Imig, Vladimı́r Tesař, Luděk Červenka   +14 more
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SP074SOLUBLE EPOXIDE HYDROLASE INHIBITION AUGMENTS RAS BLOCKADE RENOPROTECTION INSUBTOTALLY NEPHRECTOMIZED REN-2 TRANSGENIC HYPERTENSIVE RATS WITH CHRONIC KIDNEY DISEASE [PDF]

, 2018
Věra Čertíková Chábová, Petr Kujal, Petra Škaroupková, Zdeňka Vaňourková, Libor Kopkan, Zuzana Husková, Lenka Sedláková, Janusz Sadowski, Elżbieta Kompanowska‐Jezierska, Sun Wook Hwang, Bruce D. Hammock, John D. Imig, Luděk Červenka   +12 more
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Soluble epoxide hydrolase inhibition enhances anti-inflammatory and antioxidative processes, modulates microglia polarization, and promotes recovery after ischemic stroke

Neuropsychiatric Disease and Treatment, 2019
Chien-Fu Yeh,1–3,* Tung‐Yueh Chuang,4,* Yu-Wen Hung,5 Ming-Ying Lan,2,3 Ching-Han Tsai,4 Hao-Xiang Huang,4 Yung-Yang Lin1,4,6–8 1Institute of Brain Science, National Yang-Ming University, Taipei 11221, Taiwan; 2Department of ...
Yeh CF, Chuang TY, Hung YW, Lan MY, Tsai CH, Huang HX, Lin YY   +6 more
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Addition of Endothelin A-Receptor Blockade Spoils the Beneficial Effect of Combined Renin-Angiotensin and Soluble Epoxide Hydrolase Inhibition: Studies on the Course of Chronic Kidney Disease in 5/6 Nephrectomized Ren-2 Transgenic Hypertensive Rats [PDF]

, 2019
Věra Čertíková Chábová, Petr Kujal, Zdeňka Vaňourková, Petra Škaroupková, Janusz Sadowski, Elżbieta Kompanowska‐Jezierska, Vladimı́r Tesař, Bruce D. Hammock, John D. Imig, Hana Maxová, Luděk Červenka, Ivana Vaněčková   +11 more
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