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Allosteric Ensembles Elucidate Mechanisms of Inhibition in Human Soluble Epoxide Hydrolase

Conte M, Qiu Q, Carmona OG, Abis G, Fraternali F.   +4 more
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Synthetic applications of epoxide hydrolases

Current Opinion in Chemical Biology, 2001
There have been several recent advances in the area of biocatalysed hydrolytic kinetic resolution of epoxides using 'newly discovered' enzymes (i.e. epoxide hydrolases). These biocatalysts, two of which will become commercially available in the near future, appear to be highly promising tools for fine organic synthesis, as they enable the preparation ...
A, Archelas, R, Furstoss
openaire   +4 more sources

Stereoselectivities of microbial epoxide hydrolases.

Current Opinion in Chemical Biology, 1999
Epoxide hydrolases from bacterial and fungal sources are highly versatile biocatalysts for the asymmetric hydrolysis of epoxides on a preparative scale. Besides kinetic resolution, which yields the corresponding enantiomerically enriched vicinal diol and the remaining nonconverted epoxide, enantioconvergent processes are also possible, which lead to ...
R. Orru, K. Faber
semanticscholar   +3 more sources

The Telltale Structures of Epoxide Hydrolases

Drug Metabolism Reviews, 2003
Traditionally, epoxide hydrolases (EH) have been regarded as xenobiotic-metabolizing enzymes implicated in the detoxification of foreign compounds. They are known to play a key role in the control of potentially genotoxic epoxides that arise during metabolism of many lipophilic compounds.
M. Arand, A. Cronin, F. Oesch, S. Mowbray, T. Alwyn Jones   +4 more
semanticscholar   +3 more sources

Epoxide hydrolases: their roles and interactions with lipid metabolism.

Progress in Lipid Research, 2005
J. Newman, C. Morisseau, B. Hammock
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Mammalian epoxide hydrolases in xenobiotic metabolism and signalling

Archives of Toxicology, 2009
Martina Decker, M. Arand, A. Cronin
semanticscholar   +3 more sources

Cross-linked enzyme aggregates of Mung bean epoxide hydrolases: a highly active, stable and recyclable biocatalyst for asymmetric hydrolysis of epoxides.

Journal of Biotechnology, 2013
Chun-yang Yu, Xiao-feng Li, Wenyong Lou, Min-hua Zong   +3 more
semanticscholar   +3 more sources

Cytosolic epoxide hydrolase

Chemico-Biological Interactions, 1988
Epoxide hydrolase activity is recovered in the high-speed supernatant fraction from the liver of all mammals so far examined, including man. For some as yet unexplained reason, the rat has a very low level of this activity, so that cytosolic epoxide hydrolase is generally studied in mice.
J, Meijer, J W, DePierre
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Fungal epoxide hydrolases: new landmarks in sequence-activity space.

Trends in Biotechnology, 2004
M. S. Smit
semanticscholar   +3 more sources

Epoxide hydrolases: structure, function, mechanism, and assay.

Methods in Enzymology, 2005
M. Arand, A. Cronin, M. Adamska, F. Oesch   +3 more
semanticscholar   +3 more sources