Results 81 to 90 of about 45,811 (284)

Can price transparency contribute to more affordable patient access to medicines? [PDF]

, 2017
No abstract ...
Paterson, Kenneth R., Vogler, Sabine
core   +1 more source

Design of Single‐Atom Nanozymes for Precision Treatment of Erectile Dysfunction with Integrated Single‐Cell RNA Sequencing and Machine Learning

Advanced Science, EarlyView.
It is innovatively utilized single‐cell RNA sequencing to explore the underlying causes of diabetes mellitus‐induced erectile dysfunction, followed by machine learning‐driven design of a single‐atom nanozyme (Fe‐DMOF) for precision treatment of erectile dysfunction.
Xiang Zhou, Xi Zhang, Sihan Chen, Mengchi Yu, Yilan Hu, Chi Gan, Xianghu Meng, Long Li, Ninghong Song   +8 more
wiley   +1 more source

Construction of a MOF‐Based Snap‐Top Delivery Nanosystem for Powerful Dual‐Responsive Synergistic Colitis Treatment

Advanced Science, EarlyView.
A snap‐top delivery nanosystem based on an azobenzene metal–organic framework achieves targeted release of 6‐mercaptopurine via acid‐stable frameworks and hypoxia/pH dual‐responsive β‐cyclodextrin gates. This multifunctional platform integrates three synergistic mechanisms: precision drug delivery to inflammatory sites, intrinsic antioxidant properties
Xin Li, Miao Xu, Heran Li, Huan Jiang, Xin Wang, Lianjun Ma, Ying‐Wei Yang   +6 more
wiley   +1 more source

Operational intervention levels for reactor emergencies IAEA recommendations

Brazilian Journal of Radiation Sciences, 2018
The IAEA publication EPR-NPP-OILs-2017, OPERATIONAL INTERVENTION LEVELS FOR REACTOR EMERGENCIES AND METHODOLOGY FOR THEIR DERIVATION [1], provides selected default OIL values, describing a methodology for their derivation, as well as practical tools and ...
Lais Alencar de Aguiar, Arlene Alves dos Reis, Raul dos Santos   +2 more
doaj   +1 more source

A Hydrogen‐Releasing Nanozyme Engineers a Mitochondrial ROS Amplifier for Self‐Sustaining Catalytic Immunotherapy

Advanced Science, EarlyView.
We developed a RhPd‐H nanozyme that integrates enhanced POD‐mimetic catalytic activity with thermally triggered H2 release. H2 shields and reprograms mitochondria to continuously leak endogenous ·O2−. This dual‐path ROS spatially and temporally disrupts redox homeostasis, inducing persistent oxidative stress for tumor suppression and antitumor immunity,
Mingfan Shi, Jingrui Cao, Tong Wu, Guang Yang, YaWen Yang, Shixin Zhang, Wenwen Su, Hongyu Chu, Yangyang Zhao, Shan Jiang, Qiong Wu, Dongxu Jiao, Fangfang Chen   +12 more
wiley   +1 more source

Biomimetic Polymerization of Tellurocysteine: Breaking the Natural Amino Acid Radioprotection Limitation

Advanced Science, EarlyView.
Inspired by natural amino acid polymer‐melanin systems, this study strategically incorporated tellurocysteine to develop advanced radiation‐shielding materials. This approach transformed the primary interaction mechanism between melanin‐based materials and incident photons from Compton scattering to the photoelectric effect. Tellurocysteine‐polymerized
Wei Chen, Hanjie Zhu, Yue Zhang, Yuqing Qiao, Ruotong Deng, Huaping Xu, Wei Cao   +6 more
wiley   +1 more source

Direct test of time-reversal symmetry in the entangled neutral kaon system at a $\phi$-factory [PDF]

, 2012
We present a novel method to perform a direct T (time reversal) symmetry test in the neutral kaon system, independent of any CP and/or CPT symmetry tests.
A. Di Domenico, Abe, Adler, Ambrosino, Ambrosino, Ambrosino, Ambrosino, Ambrosino, Amelino-Camelia, Angelopoulos, Angelopoulos, Apostolakis, Aubert, Aubert, Banner, Banuls, Banuls, Banuls, Beringer, Bernabeu, Bernabeu, Chao, Christenson, Di Domenico, Di Domenico, Domenico, DʼAmbrosio, Einstein, J. Bernabeu, Kabir, Lees, Li, Lipkin, Lipkin, Maiani, Nakada, P. Villanueva-Perez, Quinn, Silarski, Wolfenstein, Wu, Álvarez   +41 more
core   +2 more sources

Development of an EPR-based methodology to study protein-lipid interaction

Biophysical Chemistry
ABSTRACT The interaction of protein with other biomolecules is central to all cellular processes. In particular, protein-lipid interactions play an essential role in regulating soluble and membrane protein function, structure, and dynamics.
Clara Piersson, Shikhar Prakash, Victoria Lublin, Melanie Rossotti, Baptiste Fischer, Madhur Srivastava, Yann Fichou   +6 more
openaire   +1 more source

Self‐Amplifying Redox Cycle Triggers Ferroptosis/Cuproptosis Synergy for Enhanced Bacterial Eradication

Advanced Science, EarlyView.
This study designs a targeted nanocomposite (ct@HMCF‐Dex) that responds to acidic infection microenvironments, releasing components which amplify oxidative stress. It disrupts bacterial redox balance, chelates metals to sustain lipid peroxidation, and synergistically induces cuproptosis/ferroptosis‐like death.
Zehui Xiao, Shaolong Qiu, Jiangli Cao, Jifeng Liu, Zhiyong Song, Ting Du, Xinjun Du   +6 more
wiley   +1 more source

Topology‐Dependent Coke Formation in the Catalytic Pyrolysis of Phenol Over HFAU and HZSM‐5 Zeolites

Angewandte Chemie, EarlyView.
The coke formation and speciation during the catalytic pyrolysis of lignin over different zeolite topologies were studied with a combination of operando EPR spectroscopy and ex situ pulsed techniques aided with DFT calculations. Operando EPR data showed that the coke formation in HFAU is fast compared to HZSM‐5.
Jörg W. A. Fischer, Allen Puente‐Urbina, Zeyou Pan, Mikhail Agrachev, Patrick Hemberger, Gunnar Jeschke, Jeroen A. van Bokhoven   +6 more
wiley   +2 more sources