Results 161 to 170 of about 947,323 (274)

HER2‐Targeted AIE Nanotheranostics Overcome SHR‐A1811 Resistance via Immunogenic Pyroptosis and Tumor‐Associated Macrophage Reprogramming in Breast Cancer

Small, EarlyView.
HER2‐targeted AIE780‐A1811 nanoparticles self‐assemble via amide coupling of a mitochondria‐directed photosensitizer with the ADC SHR‐A1811. Upon 660 nm irradiation, they generate ROS, photothermal effects, and controlled drug release, inducing immunogenic pyroptosis and M2‐to‐M1 macrophage reprogramming. This dual action remodels the immunosuppressive
Xiaohong Liu, Nisha Wu, Zaihui Peng, Guozhi Zhang, Lin Ren, Qiuyun Li, Jie Xiao, Jing He, Yuxiuzi Xiao, Li Ma, Yi Zhang, Ying Gong, Xiaowei Qi   +12 more
wiley   +1 more source

Real-Time Monitoring of Tissue Oxygenation During Hyperbaric Oxygen Exposure Using In Vivo EPR Oximetry. [PDF]

Magn Reson Med
Kmiec MM, Petryakov SV, Kheirollah A, Ubert CS, O'Connell RC, Kuppusamy P.   +5 more
europepmc   +1 more source

L Band EPR tooth dosimetry for heavy ion irradiation

Electron Paramagnetic Resonance (EPR) tooth dosimetry is being developed as a device to rapidly assess large populations that were potentially exposed to radiation during a major radiation accident or terrorist event.
N, Kunugita, 須田, 充, 佐藤, 斉, 484694, 濱野, 毅, 484693, 484696, 山口 一郎, 484695, 484698, 484697, 484699, 須田 充, 吉井, 裕, 濱野 毅, 川村, 拓, 川村 拓, M, Miyake, 484687, 484686, 484689, 484688, 484690, 484692, 484691, 佐藤 斉, 吉井 裕, 山口, 一郎   +27 more
core  

A lysosomal escape‐enabled endoplasmic reticulum‐targeting BODIPY photothermal agent for enhanced tumor ablation

Smart Molecules, EarlyView.
To advance precision cancer therapy, we engineered ER‐BDP NPs, a self‐assembled nanomedicine designed for selective ER localization. By integrating organelle targeting with localized laser activation, this agent mediates precision‐guided tumor destruction in vitro and in vivo while reducing off‐target effects, effectively balancing therapeutic efficacy
Shaoyang Shi, Yanbing Cao, Jiexuan Zuo, Qiushi Li, Xiaolong Zeng, Jianjun Du, Jiangli Fan, Wen Sun, Xiaojun Peng   +8 more
wiley   +1 more source

Combining Oxygen-Enhanced MRI and Electron Paramagnetic Resonance Oximetry for Quantitative OE-MRI (qOE-MRI) as a Method for Mapping Absolute Oxygen Levels (pO₂) in Tumors. [PDF]

Magn Reson Med
Ubert CS, Kassey VB, Kmiec MM, Wallin DJ, Kheirollah A, Petryakov SV, O'Connell RC, Schaner PE, Kuppusamy P.   +8 more
europepmc   +1 more source

Advances in research on layered double hydroxides for biomedical applications

Smart Molecules, EarlyView.
Layered double hydroxides (LDHs) are pH‐responsive nanomaterials with broad biomedical applications. This review summarizes LDH synthesis methods and compares their advantages. It highlights LDHs' progress in cancer therapy, including chemo‐photothermal, chemo‐immunotherapy, and photodynamic‐immunotherapy combinations and their potential in bone repair.
Xinhui Yang, Zhiping Zhang, Zhao Wang, Hao Zhang, Yen Leng Pak, Yingying Jing, Yurong Guo, Fang Li, Xiao Wang, Quanxiang Han, Lei Yu, Xuejiao Li, Xing Gao, Jibin Song   +13 more
wiley   +1 more source

Smart mesoporous silica nanoparticles for precision cancer therapy: Tumor targeting and stimuli‐responsive controlled release

Smart Molecules, EarlyView.
Smart mesoporous silica nanoparticles integrate tunable pore structures, molecular gates, targeting ligands, and stimuli‐responsive components to achieve controlled drug release for precision cancer therapy. This review highlights design principles, therapeutic applications, and future directions in immunotherapy, biodegradability, biosafety, and ...
Majdi Al‐Amili, Lei Lei, Zhu Jin
wiley   +1 more source

Engineering metal‐organic framework‐based smart porous nanoplatforms for targeted therapy and theranostic applications

Smart Molecules, EarlyView.
MOFs offer high porosity and tunability for biomedical applications, especially in cancer therapy via ROS generation and targeted delivery. Though toxicity, stability, and scalability remain key clinical challenges. Drug loading in MOFs exceeds 60%–70% with controlled release behavior.
Jagabandhu Bag, Subhasis Banerjee, Sabyasachi Banerjee, Sourav De, S. K. Ashok Kumar, Yan‐Jye Shyong, Subhankar Mukhopadhyay   +6 more
wiley   +1 more source

Lsp2 links early-life diet to adult translation and lifespan in Drosophila. [PDF]

Nature
Kosakamoto H, Okada R, Barker CS, Isomura-Matoba A, Seita J, Dohmae N, Imami K, Obata F.   +7 more
europepmc   +1 more source

Alkyl chain elongation engineering: Unlocking high‐brightness NIR‐II O‐xanthene dyes for in vivo bioimaging

Smart Molecules, EarlyView.
O‐xanthene–based fluorophore enhanced fluorescence quantum yield and brightness were achieved by extending the N‐alkyl chain on the aniline donor. Abstract NIR‐II fluorescent probes are powerful tools for advanced imaging, with performance governed by molar extinction coefficient (ε), quantum yield (Φ), and brightness (ε × Φ).
Yu Zhao, Hong Zhang, Ruirui Zhang, Wenli Xia, Zhouyu Wang, Jie Chen, Xiaoqi Yu, Kun Li   +7 more
wiley   +1 more source