Results 171 to 180 of about 947,323 (274)

Sulfur‐ and Selenium‐Decorated Coumarins: Synthetic Strategies Involving Cyclization and Late‐Stage Functionalization

open access: yesThe Chemical Record, EarlyView.
Two decades of synthetic strategies for sulfur‐, selenium‐decorated coumarins are critically surveyed through 44 literature reports, with particular emphasis on derivatives functionalized at the C‐3 and C‐4 positions. This review reports the direct construction of the coumarin framework through cyclization processes and late‐stage functionalization of ...
Bruna R. Schneider   +6 more
wiley   +1 more source

Effect of Amifostine, a Radiation-Protecting Drug, on Oxygen Concentration in Tissue Measured by EPR Oximetry and Imaging

open access: yes
Effect of amifostine, a radiation-protecting drug, on muscle tissue partial pressure of oxygen (pO2) was investigated by electron paramagnetic resonance (EPR) spectroscopy and imaging.
481401   +29 more
core  

Long non‐coding RNAs at the crossroads of inflammation, cancer and angiogenesis: Molecular mechanisms and their potential as therapeutic targets

open access: yesBritish Journal of Pharmacology, EarlyView.
Long non‐coding RNAs (lncRNAs), a broad class of non‐protein‐coding RNAs, are characterized as new regulators of gene expression at the epigenetic, transcriptional, and post‐transcriptional level. Thus, lncRNAs are involved in the regulation of physiological processes and the development of human diseases and cancer by modulating proinflammatory ...
Charlie Leboff   +3 more
wiley   +1 more source

GCN5L1-Mediated Lysine Acetylation Regulates Mitochondrial Bioenergetics and Redox Homeostasis in the Aged Heart. [PDF]

open access: yesAntioxidants (Basel)
Stewart JE   +8 more
europepmc   +1 more source

Directional information flow in human frataxin defines allosteric pathways connecting the hydrophobic core to the iron‐binding ridge

open access: yesThe FEBS Journal, EarlyView.
Human frataxin deficiency causes Friedreich's ataxia, yet how iron‐binding events are communicated across the protein is unclear. Using transfer entropy analysis of molecular dynamics simulations, we identify buried hydrophobic core leucines (LEU136, LEU140) as the source of directional signaling toward the iron‐binding acidic ridge.
Kevser Kübra Kırboğa   +1 more
wiley   +1 more source

A comprehensive study on ferredoxin isoforms in the cyanobacterium Synechocystis sp. PCC 6803

open access: yesThe FEBS Journal, EarlyView.
Ferredoxins are small FeS cluster‐containing proteins that play a central role in distributing electrons within the cell. The cyanobacterium Synechocystis sp. PCC 6803 contains several ferredoxin isoforms and their biophysical properties (UV/Vis and EPR spectra, Em potential), expression patterns, and interactions with the electron donors photosystem I
Marko Boehm   +14 more
wiley   +1 more source

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