Advanced Science, Volume 13, Issue 61, 3 November 2026.A nanomodulator called L‐Arginine/lificiguat@Copper‐hollow Prussian blue@Calcium phosphate nanoparticles is constructed to launch a self‐amplifying “avalanche effect” in tumor cells. The ensuing cascade, triggered by the acidic tumor microenvironment and near‐infrared light, induces calcium overload, generates a reactive oxygen species and reactive ...
Hongmei Zhou +9 more
wiley +1 more source
Angewandte Chemie, Volume 138, Issue 44, 26 October 2026.Cancer stem cells (CSCs) drive metastasis, relapse and resist conventional apoptosis‐inducing chemotherapies. We report a cobalt(III)‐cyclam complex with pyrene and diflunisal moieties that reduces the viability of breast CSCs at low micromolar concentrations.
Jiaxin Fang +7 more
wiley +2 more sources
Chemical Bond‐Orchestrated Energy Depletion to Augment Lung Cancer Chemo‐Immunotherapy
Advanced Science, Volume 13, Issue 61, 3 November 2026.This study grafted dichloroacetic acid (DCA) into perylenediimide (PDI) skeleton via ionic or covalent bond to create novel metabolic agent PDIC‐AC and PDIC‐NAC, explicitly elaborated the underlying energy metabolism and therapeutic mechanism, and developed a promising strategy for energy metabolism‐targeting chemo‐immunotherapy by chemical bond ...
Xuejie Zhao +5 more
wiley +1 more source
The Application Potential and Future Challenges of Plant-Derived Exosome-like Nanoparticles in the Treatment of Liver Diseases. [PDF]
PharmaceuticsYe L +7 more
europepmc +1 more source
Immune Markers and Risk of Pancreatic Cancer in the European EPIC Cohort
International Journal of Cancer, Volume 159, Issue 9, Page 2146-2157, 1 November 2026.The immune system has been implicated as a major driver in pancreatic cancer etiology. Previous cohort studies have found associations between pancreatic cancer and single immune system‐derived markers, but omics‐based evidence remains scarce. In this prospective case–control study, the authors investigated 92 proteins involved in immune reactions and ...
Verena A. Katzke +28 more
wiley +1 more source
In vivo dynamic nuclear polarization magnetic resonance imaging reveals cardiac mitochondrial redox imbalance as an early indicator of heart failure. [PDF]
Redox BiolIchihashi K +10 more
europepmc +1 more source
Neutrophils: Heterogeneity, Biology, Diseases, and Therapeutic Strategies
MedComm, Volume 7, Issue 11, November 2026.Neutrophils exhibit remarkable functional plasticity and play dual roles in tissue protection and disease progression. This review summarizes their key biological functions and highlights the shift from conventional broad‐spectrum interventions to neutrophil‐based drug delivery systems.
Yibing Zhang +4 more
wiley +1 more source
ALDH Inhibition‐Primed Photocatalysis Disrupts Cancer Stemness Plasticity
Angewandte Chemie, Volume 138, Issue 43, 19 October 2026.DE‐Et converts ALDH‐mediated redox buffering into a photoredox vulnerability by coupling ALDH inhibition with red‐light‐driven catalytic NADH oxidation. This enzyme‐coupled photoredox strategy sustains mitochondrial NADH/NAD+ imbalance, induces pyroptotic tumor cell death, suppresses tumor growth in vivo, and promotes systemic antitumor immunity ...
Yujin Kim +10 more
wiley +2 more sources
Inflammatory Syndrome Regulated by WNT/β-Catenin, Non-Muscle Myosin and α-SMA Is a Self-Organized Dissipative Structure. [PDF]
Biology (Basel)Lecarpentier Y +3 more
europepmc +1 more source
Isotope-edited ESEEM: A new method for probing copper binding sites in neurodegenerative proteins. [PDF]
J Biol ChemMillhauser GL +3 more
europepmc +1 more source