Results 81 to 90 of about 45,358 (304)

Multi‐Enzyme Mimetic Molybdenum Nitride Nanozymes Reshape Subgingival Microenvironment for Synergistic Periodontitis Therapy via ROS Regulation and Microbiome Remodeling

Advanced Science, EarlyView.
ABSTRACT Periodontitis, a chronic inflammatory disease initiated and sustained by plaque microorganisms and host immune response, remains an intractable oral disease and a leading cause of tooth loss worldwide. Traditional mechanical debridement and adjunctive antibiotic or antiseptic therapy often shows limited efficacy due to the complex anatomical ...
Weiyu Zhang, Zhongwei Yang, Yunfan Zhang, Longwei Wang, Xiaoyu Zhang, Jiahui Mao, Yizhi Dai, Yifan Yuan, Mingge Wang, Xin Yang, Xin Yu, Jing Liu, Chunying Chen   +12 more
wiley   +1 more source

Structural heterogeneity of α-synuclein fibrils amplified from patient brain extracts

Nature Communications, 2019
Parkinson’s disease (PD) and Multiple System Atrophy (MSA) are characterized by the pathological accumulation of α-synuclein. Here the authors employ fluorescent probes, electron microscopy and NMR spectroscopy to study the properties of α-synuclein ...
Timo Strohäker, Byung Chul Jung, Shu-Hao Liou, Claudio O. Fernandez, Dietmar Riedel, Stefan Becker, Glenda M. Halliday, Marina Bennati, Woojin S. Kim, Seung-Jae Lee, Markus Zweckstetter   +10 more
doaj   +1 more source

High-spin Metal Centres in Dipolar EPR Spectroscopy

CHIMIA, 2018
The substitution of Mg2+ by Mn2+ in the bacterial DnaB helicase from Helicobacter pylori, an ATP:Mg2+-fuelled protein engine, allows electron paramagnetic resonance (EPR) spectroscopy to be performed on this system.
Katharina Keller, Thomas Wiegand, Riccardo Cadalbert, Beat H. Meier, Anja Böckmann, Gunnar Jeschke, Maxim Yulikov   +6 more
doaj   +1 more source

Dual‐Responsive Dynamic Covalent Bond‐Based Assembly of Lipid‐Nanozyme Systems via Multi‐Target Synergy and Efficient Target Enrichment for Ischemic Stroke Therapy

Advanced Science, EarlyView.
This system adopts a biomimetic phospholipid structure, covalently binding iNOS inhibitors, neuroprotective agent PCA and vitamin E derivatives through pH/ROS dual‐responsive bonds, and assembles them with Prussian blue nanozyme to form PBB@AHA. It can efficiently penetrate the blood‐brain barrier and simultaneously release multiple active components ...
Mengcheng Guo, Qingran Guan, Guanyu Qiao, Lixue Zhang, Man Liu, Zhen Li, Qingbiao Yang, Meili Shen, Linlin Liu, Yapeng Li   +9 more
wiley   +1 more source

Advancements in electron paramagnetic resonance (EPR) spectroscopy: A comprehensive tool for pharmaceutical research

Acta Pharmaceutica
Electron paramagnetic resonance (EPR) spectroscopy has long been established across various scientific disciplines for characterizing organic radicals, organometallic complexes, protein structures and dynamics, polymerization processes, and radical ...
Bešić Erim, Rajić Zrinka, Šakić Davor   +2 more
doaj   +1 more source

Electron Paramagnetic Resonance in Lignocellulosic Biomass Pyrolysis Mechanism: Advancements, Applications, and Prospects

Energies
Lignocellulosic biomass can be converted into high-value-added bio-based materials through pyrolysis; however, an unclear pyrolysis mechanism hinders its further application.
Zhongyang Luo, Longyi Liu, Feiting Miao, Wanchen Zhu, Longfei Li, Yuanlin Wang   +5 more
doaj   +1 more source

Oral Bioinspired Peroxisome‐Engineered Probiotics for Modulating Gut Microbiota Homeostasis and Alleviating Cardiac Chemotherapy Toxicity

Advanced Science, EarlyView.
This study developed an oral bioinspired peroxisome‐engineered probiotic (BPEP) by anchoring lipid‐encapsulated ruthenium nanozymes onto Escherichia coli Nissle 1917, utilizing probiotics to deliver nanozymes to the intestinal barrier for reactive oxygen species/reactive nitrogen species elimination, tight junction restoration, and gut microbiota ...
Shuyu Wang, Xiaowan Fan, Chao Zhang, Shuai Han, Yike Guo, Yuchen Wang, Wei Wang, Junyue Xing, Ying Liu, Wei Jiang, Xiaoying Chen   +10 more
wiley   +1 more source

EPR Spectroscopy

, 2020
Suggested mechanisms for NH3‐SCR on V2O5 /TiO 2 based catalysts contain both oxidized and reduced vanadium species. The degree of reduction and the importance of the redox properties of the catalyst are however still widely discussed.
Anita L. Godiksen, Marie H. Funk, Søren B. Rasmussen, Susanne Mossin, Funk, Marie H., Godiksen, Anita Lundager, Rasmussen, Søren Birk, Mossin, Susanne   +7 more
core   +1 more source

Real-time Monitoring of Photoinduced pH-jumps by In Situ Rapid-scan EPR Spectroscopy

, 2023
This work represents the first demonstration of a light-induced pH-switchable process monitored by in situ rapid-scan (RS) electron paramagnetic resonance (EPR) spectroscopy on the millisecond timescale.
Malte, Drescher, Florian, Johannsen, Lara , Williams, Man Him, Chak   +3 more
core   +1 more source

Frustrated Lewis Pairs and Metallic Ni Synergistically Enabled Low‐Temperature Hydrogenolysis of Lignin Models

Advanced Science, EarlyView.
Nickel–aluminum composite oxide (NiAlOx‐300) derived from NiAl layered double hydroxide showed high activity for hydrogenolysis of various lignin models. Especially, hydrogenolysis of benzyl phenyl ether could be efficiently proceeded at 20°C and 1 MPa H2.
Jinpeng Liang, Ziyi Ma, Zhaoxi Cai, Kongqian Liang, Chenglei Xiao, Sitong Chen, Na Wang, Zhimin Xue, Chao Xie, Jinliang Song   +9 more
wiley   +1 more source