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Epsilon-Aminocaproic Acid (EACA)

open access: yesSeminars in Thrombosis and Hemostasis, 2008
Epsilon-aminocaproic acid (EACA) is a synthetic inhibitor of the plasmin-plasminogen system. It is the only potent antifibrinolytic agent which is commercially available in the United States. Effective blood levels of the drug are readily obtainable with either oral or intravenous administration, with very high levels of the drug being found in the ...
J D, Griffin, L, Ellman
openaire   +3 more sources
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Reduction of Postprostatectomy Bleeding by Epsilon-Aminocaproic Acid

New England Journal of Medicine, 1962
EPSILON-aminocaproic acid (EACA) is a potent inhibitor of plasminogen activation in relatively low concentrations (5 × 10–4M) and of plasmin at considerably higher concentrations (1 × 10–2M).1 , 2 This drug, first described by Japanese investigators, has the structural formula: Clinical studies have indicated that it is effective in hemorrhagic ...
Theodore H Spaet   +2 more
exaly   +3 more sources

Epsilon Aminocaproic Acid — A Dangerous Weapon

open access: yesNew England Journal of Medicine, 1969
Of the body's defenses against injury, the proteolytic activity of plasmin, an enzyme that can evolve in plasma from an inert precursor, plasminogen, is most intriguing. Clinical attention has been centered upon the digestion of fibrin by plasmin, but this enzyme also digests other clotting factors, converts the first component of complement to its ...
Oscar D. Ratnoff
openaire   +3 more sources

Rhabdomyolysis During Treatment With Epsilon-Aminocaproic Acid

open access: yesArchives of Neurology, 1980
Severe rhabdomyolysis and acute renal failure occurred in a patient receiving epsilon-aminocaproic acid. The lack of evidence of vascular involvement in the muscle biopsy specimen suggests that epsilon-aminocaproic acid may have direct myotoxicity. This drug may produce a spectrum of muscle disease from mild myopathy to life-threatening rhabdomyolysis.
C W, Britt   +3 more
openaire   +3 more sources

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