Results 161 to 170 of about 10,597 (237)

Rhabdomyolysis Induced by Epsilon-Aminocaproic Acid

Annals of Pharmacotherapy, 1997
OBJECTIVE: To report a case of rhabdomyolysis associated with epsilon-aminocaproic acid (epsilon-ACA). CASE SUMMARY: A 33-year-old female patient with chronic granulocytic leukemia was treated with epsilon-ACA for approximately 3.5 months for thrombocytopenic bleeding. The initial dosage was 4 g po q6h.
B D, Seymour, M, Rubinger
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Comparison of different dosage regimes of epsilon aminocaproic acid on blood loss in children undergoing craniosynostosis surgery

Paediatric anaesthesia, 2019
Open cranial vault reconstruction is frequently performed for craniosynostosis. These procedures often involve high volume blood loss that requires blood transfusion.
Thanh T Nguyen, Humphrey V Lam, T. Austin, P. Stricker, Huseyin Tunceroglu, J. Schoenecker   +5 more
semanticscholar   +1 more source

Myopathy induced by epsilon-aminocaproic acid

Journal of Neurosurgery, 1982
✓ The authors present a case of proximal myopathy secondary to epsilon-aminocaproic acid (EACA) administration. This well recognized entity does not occur immediately after institution of therapy, but follows a delay of several days and a cumulative dose.
J A, Brown, R L, Wollmann, S, Mullan
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Epsilon Aminocaproic Acid — A Dangerous Weapon

New England Journal of Medicine, 1969
Of the body's defenses against injury, the proteolytic activity of plasmin, an enzyme that can evolve in plasma from an inert precursor, plasminogen, is most intriguing. Clinical attention has been centered upon the digestion of fibrin by plasmin, but this enzyme also digests other clotting factors, converts the first component of complement to its ...
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Epsilon-Aminocaproic acid therapy in ulcerative colitis

The American Journal of Digestive Diseases, 1973
A double-blind cross-over trial of the effect of Epsilon-Aminocaproic acid (EACA) versus placebo on gastrointestinal blood loss in 13 patients with proctocolitis showed no statistically significant reduction in blood loss recorded by the disappearance rate, as detected by whole-body monitoring of parenterally administered59Fe.
N A, Mowat, A S, Douglas, P W, Brunt, J A, McIntosh, P C, King, K, Boddy   +5 more
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HAEMORRHAGIC CYSTITIS TREATED WITH EPSILON–AMINOCAPROIC ACID

Medical Journal of Australia, 1980
A life-threatening haemorrhagic cystitis, which occurred in a patient with metastatic prostatic carcinoma, was controlled with epsilon-aminocaproic acid (EACA) after conventional approaches to treatment failed. EACA administration was both systemic and intravesical, and control of bleeding occurred within 24 hours after initiation of treatment.
R S, Aroney, D N, Dalley, J A, Levi
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Rhabdomyolysis During Treatment With Epsilon-Aminocaproic Acid

Archives of Neurology, 1980
Severe rhabdomyolysis and acute renal failure occurred in a patient receiving epsilon-aminocaproic acid. The lack of evidence of vascular involvement in the muscle biopsy specimen suggests that epsilon-aminocaproic acid may have direct myotoxicity. This drug may produce a spectrum of muscle disease from mild myopathy to life-threatening rhabdomyolysis.
C W, Britt, R R, Light, B H, Peters, S S, Schochet   +3 more
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The Efficacy and Safety of Epsilon-Aminocaproic Acid for Perioperative Blood Management in Spinal Fusion Surgery: A systematic review and meta-analysis.

World Neurosurgery, 2021
Shang Li, F. Xing, Y. Cen, Zhen-yu Zhang
semanticscholar   +1 more source

epsilon-Aminocaproic Acid Plasma Levels During Cardiopulmonary Bypass

Anesthesia & Analgesia, 1997
epsilon-Aminocaproic acid (EACA) concentrations achieved during cardiopulmonary bypass (CPB) have not been previously reported. It is unknown whether plasma concentrations reported to inhibit fibrinolysis in vitro (130 microg/mL) are achieved or whether differences in these levels relate to variability in postoperative bleeding.
E, Bennett-Guerrero, J G, Sorohan, A T, Canada, L, Ayuso, M F, Newman, J G, Reves, M G, Mythen   +6 more
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Reduction of Postprostatectomy Bleeding by Epsilon-Aminocaproic Acid

New England Journal of Medicine, 1962
EPSILON-aminocaproic acid (EACA) is a potent inhibitor of plasminogen activation in relatively low concentrations (5 × 10–4M) and of plasmin at considerably higher concentrations (1 × 10–2M).1 , 2 This drug, first described by Japanese investigators, has the structural formula: Clinical studies have indicated that it is effective in hemorrhagic ...
E, Sack, T H, Spaet, R L, Gentile, P B, Hudson   +3 more
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