Results 51 to 60 of about 17,243 (178)

TRPM3 regulates fear memory encoding and seizure susceptibility in the lateral amygdala

British Journal of Pharmacology, EarlyView.
Abstract Background and purpose TRPM3 is best known for its role as a peripheral sensor of pain and heat. Recent studies reporting gain‐of‐function TRPM3 mutations in patients with neurodevelopmental and epilepsy‐associated disorders suggest a previously unrecognized role of this channel in the brain.
Attila Gyéresi, Laura Mundrucz, Máté Deák, Angéla Kecskés, Éva Borbély, Viktória Kormos, Balázs Gaszner, Orsolya Mihály, Balázs István Tóth, Joris Vriens, Thomas Voets, Erzsébet Kövesdi, Miklós Kecskés   +12 more
wiley   +1 more source

Patent landscape analysis of inventions based on plant genetic resources for food and agriculture and related digital sequence information

The Journal of World Intellectual Property, EarlyView.
Abstract This article provides an overview of the patent landscape in relation to PGRFA‐based inventions involving naturally occurring (“native”) traits and related Digital Sequence Information/Genetic Sequence Data (DSI/GSD). In particular, it focuses on the potential of patent claims to limit others' uses of PGRFA and related DSI/GSD on which the ...
Claudio Chiarolla, Michael Andreas Kock, Paul Oldham, Michael Halewood, Isabel López Noriega, Jasmine Kindness   +5 more
wiley   +1 more source

Weak and straddling secondary nicotinic synapses can drive firing in rat sympathetic neurons and thereby contribute to ganglionic amplification

Frontiers in Neurology, 2010
Interactions between nicotinic EPSPs critically determine whether paravertebral sympathetic ganglia behave as simple synaptic relays or as integrative centers that amplify preganglionic activity.
Katrina Rimmer, John P Horn
doaj   +1 more source

Paternal chromosome elimination of inducer triggers induction of double haploids in Brassica napus

Frontiers in Plant Science, 2023
A synthetic octoploid rapeseed, Y3380, induces maternal doubled haploids when used as a pollen donor to pollinate plant. However, the mechanism underlying doubled haploid formation remains elusive.
Shihui Zhao, Shihui Zhao, Liangjun Huang, Liangjun Huang, Qing Zhang, Ying Zhou, Ying Zhou, Meicui Yang, Meicui Yang, Haoran Shi, Yun Li, Jin Yang, Chao Li, Xianhong Ge, Wanzhuo Gong, Jisheng Wang, Qiong Zou, Lanrong Tao, Zeming Kang, Zhuang Li, Chaowen Xiao, Qiong Hu, Shaohong Fu, Shaohong Fu   +23 more
doaj   +1 more source

Metabolic Rewiring of the Shikimate Pathway Enables Rose‐Scented Rice

Plant Biotechnology Journal, EarlyView.
ABSTRACT Rice fragrance is a key determinant of grain quality, yet the aroma profile of cultivated rice is highly uniform and largely dominated by the popcorn‐like compound 2‐acetyl‐1‐pyrroline. Here we expanded the aromatic repertoire of rice by engineering a rose‐like fragrance through reconstruction of the phenylalanine‐derived 2‐phenylethanol (2‐PE)
Xiaoqing Cui, Wenhao Yao, Honglin Yang, Yangning Ou, Keyi Chen, Yifei Qin, Chengxuan Li, Boxi Zhu, Wenyi Wang, Jiayang Li, Mengyun Xu, Jian Wu   +11 more
wiley   +1 more source

Deciphering the structure of Arabidopsis thaliana 5-enol-pyruvyl-shikimate-3-phosphate synthase: An essential step toward the discovery of novel inhibitors to supersede glyphosate

Computational and Structural Biotechnology Journal, 2022
Glyphosate interferes with plant aromatic metabolism through the inhibition of 5-enol-pyruvyl-shikimate-3-phosphate (EPSP) synthase [EPSPS, EC 2.5.1.19]. For this reason, EPSPS has been extensively studied in a vast array of organisms.
Milosz Ruszkowski, Giuseppe Forlani
doaj   +1 more source

A Computational Framework for Myelin as a Regulator of Temporal Integration, Neuronal Excitability, and Synaptic Plasticity

Glia, Volume 74, Issue 12, December 2026.
Computational models illustrate how myelinating glia may shape the temporal integration of spikes upon a common postsynaptic target. Models show consequences for synaptic plasticity, neuronal excitability, and the fidelity of neural signals. ABSTRACT Myelin regulates neural signaling not only by enabling fast conduction but also by dynamically tuning ...
Daniel O'Sullivan, Aref Pariz, Daniel Trotter, Noor Z. Al Dahhan, Juliet K. Knowles, Paul W. Frankland, Donald Mabbott, Jérémie Lefebvre   +7 more
wiley   +1 more source

Herbicidas inibidores da EPSPs: revisão de literatura [PDF]

, 2000
The herbicides inhibitors ofthe enzyme EPSPs, glyphosate and sulfosate, are among the most used compounds in Brazil and in the world. The objectives ofthis review are to synthesize the information about the weeds controlled, physic-chemical ...
Trezzi, Michelangelo M., Kruse, Nelson D., Vidal, Ribas A.   +2 more
core  

Serotonin engages divergent 5‐HT receptor pathways for cell type‐resolved modulation of prefrontal layer 5 microcircuits

British Journal of Pharmacology, Volume 183, Issue 19, Page 5832-5853, October 2026.
Serotonin differentially modulates layer 5 mPFC microcircuits through cell type‐specific pre‐ and postsynaptic receptor pathways. Presynaptic 5‐HT1BRs suppress glutamate and GABA release, whereas presynaptic and postsynaptic 5‐HT3ARs enhance fast‐spiking interneuron activity, whilst distinct pyramidal neuron subtypes exhibit divergent 5‐HT1AR‐ and 5 ...
Ramya Rama, Guanxiao Qi, Gabriele Radnikow, Danqing Yang, Dirk Feldmeyer   +4 more
wiley   +1 more source

Sequence alignment of the EPSPS proteins from the Solanaceae family.

, 2018
EPSPS amino acid sequences from Capsicum annuum, Nicotiana attenuata, Nicotiana sylvestris, Nicotiana tabcum, Nicotiana tomentosiformis, Petunia hybrida, Solanum lycopersicum, Solanum pennellii and Solanum tuberosum were compared to the sequences of Zea ...
Wathsala Rajapakse (5094641), Kimberly Apodaca (5094629), Yvonne Lucero (5094635), Champa Sengupta-Gopalan (5094632), Suman Bagga (5094644), Jose Luis Ortega (5094638)   +5 more
core   +1 more source