Results 61 to 70 of about 17,243 (178)

A novel 5-enolpyruvylshikimate-3-phosphate synthase from Rahnella aquatilis with significantly reduced glyphosate sensitivity.

PLoS ONE, 2012
The 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS; EC 2.5.1.19) is a key enzyme in the shikimate pathway for the production of aromatic amino acids and chorismate-derived secondary metabolites in plants, fungi, and microorganisms.
Ri-He Peng, Yong-Sheng Tian, Ai-Sheng Xiong, Wei Zhao, Xiao-Yan Fu, Hong-Juan Han, Chen Chen, Xiao-Fen Jin, Quan-Hong Yao   +8 more
doaj   +1 more source

Increased Expression of α‐Synuclein Impairs Trafficking of the Essential SNARE Protein Synaptobrevin‐2

Journal of Neurochemistry, Volume 170, Issue 10, October 2026.
α‐Synuclein is a presynaptic protein extensively studied for its role in Parkinson's disease; however, its native function remains unclear. Here, we show that modest (approximately 2‐fold) overexpression of α‐synuclein in cultured neurons, at levels observed in familial synucleinopathies with SNCA triplication, impairs the endocytic retrieval of the ...
Elyas H. Arvell, James P. Carroll, Joshua Saito, Holly Melland, Ranjith R. Unnithan, Chris French, Danny M. Hatters, Sarah L. Gordon   +7 more
wiley   +1 more source

A Modified phosphate-carrier protein theory is proposed as a non-target site mechanism For glyphosate resistance in weeds Teoria das proteínas carregadoras fosfato modificadas proposta como mecanismo de resistência ao herbicida glyphosate em plantas daninhas

Planta Daninha, 2010
Glyphosate is an herbicide that inhibits the enzyme 5-enolpyruvyl-shikimate-3-phosphate synthase (EPSPs) (EC 2.5.1.19). EPSPs is the sixth enzyme of the shikimate pathway, by which plants synthesize the aromatic amino acids phenylalanine, tyrosine, and ...
A.C. Roso, R.A. Vidal
doaj   +1 more source

Types of Neurons in the Myenteric Plexus of Human Gastric Corpus Identified by Multi‐Layer Immunohistochemical Coding and Vagal Tracing

Neurogastroenterology &Motility, Volume 38, Issue 10, October 2026.
Myenteric nerve cell bodies in the human gastric corpus were divided into 12 classes by the combinatorial expression of 15 neuronal markers, using multiplexed immunohistochemistry (1084 neurons from 7 individuals). Baskets of axonal varicosities from vagal or enteric sources were analyzed to detect targeted patterns of connectivity ...
M. E. Johnson, M. Wee, B. N. Chen, A. Humenick, R. A. Peterson, W. P. Yew, T. J. Hibberd, D. A. Wattchow, L. Kow, T. L. Powley, S. J. H. Brookes   +10 more
wiley   +1 more source

EPSPs obtained with different T-distributions.

, 2014
(A-D) EPSPs at different locations along a single dendritic branch (branch 3), as a response to synaptic input () applied to the dendritic endpoint. Different panels represent different T-distributions, as indicated.
Vaneeda Allken (636441), Geir Halnes (343071), Joy-Loi Chepkoech (636442), Gaute T. Einevoll (267626)   +3 more
core   +1 more source

Palmitoylation of PSD‐95 Orchestrates Learning‐Dependent Metaplasticity in the Amygdala and Fear Memory

Advanced Science, Volume 13, Issue 52, 18 September 2026.
This study reveals that fear learning specifically triggers PICK1/DHHC2‐dependent palmitoylation of PSD‐95 in the lateral amygdala. Fear conditioning induces the dissociation of DHHC5 from PSD‐95 and the association of PSD‐95 with DHHC2. DHHC2‐mediated palmitoylation of PSD‐95 is required for synaptic transmission and underlies fear learning–induced ...
Zu‐Cheng Shen, Yu‐Xuan Weng, Zhi‐Xuan Xia, Yue‐Ling Zhao, Qian‐Qian Ding, Si‐Ying Wang, Ting Cao, Xuan‐Ying Chen, Wu‐Cheng Tao, Shen Lin, Zhou Chen, Yi‐Xiao Luo   +11 more
wiley   +1 more source

EPSPS Gene Copy Number and Whole-Plant Glyphosate Resistance Level in Kochia scoparia.

PLoS ONE, 2016
Glyphosate-resistant (GR) Kochia scoparia has evolved in dryland chemical fallow systems throughout North America and the mechanism of resistance involves 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS) gene duplication.
Todd A Gaines, Abigail L Barker, Eric L Patterson, Philip Westra, Eric P Westra, Robert G Wilson, Prashant Jha, Vipan Kumar, Andrew R Kniss   +8 more
doaj   +1 more source

Parvalbumin interneurons in Alzheimer's disease: Physiological insights and pathophysiological mechanisms

Journal of Cell Communication and Signaling, Volume 20, Issue 3, September 2026.
Physiological and Pathological Alterations in PV+ Neurons: Under physiological conditions, PV+ interneurons exhibit fast‐spiking properties and generate gamma oscillations at the cost of high energy consumption. In AD, PV+ neurons display abnormalities in ion channels, dendrites, neurotransmission, energy metabolism, and neural oscillations, ultimately
Mengyan Wu, Xingdong Zeng, Yongle Cai, Haonan Chen, Qianying Li, Hao Yang   +5 more
wiley   +1 more source

Electrical advantages of dendritic spines.

PLoS ONE, 2012
Many neurons receive excitatory glutamatergic input almost exclusively onto dendritic spines. In the absence of spines, the amplitudes and kinetics of excitatory postsynaptic potentials (EPSPs) at the site of synaptic input are highly variable and depend
Allan T Gulledge, Nicholas T Carnevale, Greg J Stuart   +2 more
doaj   +1 more source

Voltage-Gated Sodium Channels Shape Subthreshold EPSPs in Layer 5 Pyramidal Neurons From Rat Prefrontal Cortex

, 2001
The role of voltage-dependent channels in shaping subthreshold excitatory postsynaptic potentials (EPSPs) in neocortical layer 5 pyramidal neurons from rat medial prefrontal cortex (PFC) was investigated using patch-clamp recordings from visually ...
German Barrionuevo, Guillermo González-Burgos   +1 more
core   +1 more source