Results 51 to 60 of about 202,744 (245)

NIPAL1 Drives a Metabolic‐Epigenetic Feedback Loop to Promote Lactate‐Mediated Immune Evasion in Esophageal Cancer

Advanced Science, EarlyView.
The study identifies a NIPAL1‐driven metabolic‐epigenetic circuit in esophageal squamous cell carcinoma that promotes glycolysis, lactate accumulation, and H3K18 histone lactylation, forming a self‐sustaining loop that suppresses CD8+ T cell immunity.
Ri‐Xin Chen, Xiao‐Dan Ma, Shui‐Dan Xu, Ao‐Tian Mo, Min‐Hua Deng, Jun‐Han Wu, Wei‐Tao Zhuang, Jin‐Ling Duan, Shu‐Huan Xie, Jin‐Long Lin, Peng Lin, Ji‐Ming Tang, Hai‐Yu Zhou, Xiao‐Song Ben, Gui‐Bin Qiao, Dan Xie   +15 more
wiley   +1 more source

DETECTION OF EPSTEIN BARR VIRUS IN RENAL TRANSPLANT RECIPIENTS: TWO CENTERS STUDY

The Iraqi Journal of Medical Sciences
Background:Viruses are among the most common causes of opportunistic infections after transplantation. The risk for viral infection is a function of the specific virus encountered and the intensity of immune suppression used to prevent graft rejection ...
Sahar A. Shams-aldein, Ahmed S. Abdlameer, Asmaa B. Al-Obaidi, Haider S. Kadhim, Ali J.Al-Saedi   +4 more
doaj   +6 more sources

About features clinical acute Epstein-Barr virus infection in children syndrome undifferentiated Connective tissue dysplasia

Журнал инфектологии, 2014
The aim of the study was to investigate the clinical course of acute Epstein-Barr virus infection in children with the syndrome undifferentiated connective tissue dysplasia.
S. N. Orlova, S. A. Machin, S. V. Zhambarova   +2 more
doaj   +1 more source

Epstein-Barr Virus-induced Jaundice [PDF]

, 2020
Infectious mononucleosis is primarily caused by Epstein-Barr virus (EBV) and is a common di-agnosis made in emergency departments worldwide. Subclinical and transient transaminase ele-vations are a well-established sequela of EBV.
Grimaldo, Felipe, Herold, Jessica
core  

Measurement of Epstein-Barr virus DNA load using a novel quantification standard containing two EBV DNA targets and SYBR Green I dye [PDF]

, 2016
BACKGROUND Reactivation of Epstein-Barr virus (EBV) infection may cause serious, life-threatening complications in immunocompromised individuals. EBV DNA is often detected in EBV-associated disease states, with viral load believed to be a reflection of ...
Ausimmune Investigator Group (AIG), Dwyer, Dominic E, Lay, Meav-Lang J, Lucas, Robyn, Ponsonby, Anne-Louise, Ratnamohan, Mala, Taylor, Janette   +6 more
core   +1 more source

Androgen Receptor‐Induced Lactoferrin Accelerates Prostate Tumorigenesis Through Modulating Ferroptosis

Advanced Science, EarlyView.
This study demonstrates that transcription factor androgen receptor (AR) directly binds the LF promoter, driving lactoferrin overexpression to promote ferritin (FTH1/FTL) upregulation and inhibit p53‐ALOX12‐mediated ferroptosis in prostate cancer. Lactoferrin could be a new potential therapeutic target in prostate cancer.
Can Liu, Qiu Peng, Xiaoyue Zhang, Zhengshuo Li, Yangge Wu, Yuqing Wen, Run Zheng, Shuanglong Wu, Chenfei Zhou, Zhengyu Hu, Lanjun Shu, Xinyi Ma, Qiuyang Li, Ya Ma, Chunlin Ou, Ming Zhao, Songqing Fan, Lingyu Wei, Jian Ma   +18 more
wiley   +1 more source

Presencia del virus de Epstein-Barr en casos colombianos de linfoma de Hodgkin y su relación con la respuesta al tratamiento.

Biomédica: revista del Instituto Nacional de Salud, 2004
En el desarrollo y patogénesis del linfoma de Hodgkin se ha propuesto al virus de Epstein-Barr como posible factor etiológico debido a la detección de ADN viral en las células de Reed- Sternberg en un subgrupo de tumores y a los altos niveles de ...
Sandra Quijano, Carlos Saavedra, Susana Fiorentino, Oscar Orozco, María Mercedes Bravo   +4 more
doaj   +1 more source

Immunosenescence and lymphomagenesis [PDF]

, 2018
One of the most important determinants of aging-related changes is a complex biological process emerged recently and called \u201cimmunosenescence\u201d.
A Beheshti, A Engert, A Grignolio, A Nicolae, A Rosenwald, A Tucci, AM Evens, BB Hart, BF Skinnider, BK Edwards, BO Nilsson, C Caruso, C Castelo-Branco, C Falandry, C Falandry, C Franceschi, C Franceschi, C Kenis, C Sarkozy, C Sarkozy, C Thieblemont, CC Porter, CM Koebel, D Aldinucci, D Hanahan, D Zhou, DB Palmer, DM Parkin, DP Shanley, E Campo, E Cesarman, E Zucca, F Suarez, FL Erdkamp, FT Hakim, G Accardi, G Genovese, G Lenz, G Pawelec, GM Clifford, H Wildiers, I Schwering, J Campisi, J Wang, JJ Castillo, L Malaguarnera, LM Morton, M Goto, M Martelli, M Weltevrede, Marco Santoro, Mariasanta Napolitano, Melania Carlisi, N Asano, NS Wong, O Balague Ponz, P Skrabek, PJ Linton, PR Taylor, PR Walker, R Kim, RF Jarrett, RL Bowman, RR Montgomery, S Dubois, S Joos, S Mareschal, S Mathas, S Mathas, S Puvvada, Salvatrice Mancuso, Sergio Siragusa, SH Swerdlow, Simona Raso, SJ Morrison, SJ Proctor, SL Glaser, SR Gordon, SR Hadrup, T Finkel, T Fulop, T Fulop, T Fülöp, T Fülöp, T Fülöp, T Ishida, T Wada, W Drew, W Klapper, Z Ju, Z Song   +90 more
core   +1 more source

Phenotypic Diversity and Outcomes in Pediatric NMDA Receptor Encephalitis: A 15‐Year Retrospective Study from the Largest Children's Hospital in the United States

Advanced Science, EarlyView.
ABSTRACT Anti‐NMDAR encephalitis (NMDARE) is an autoantibody‐mediated disorder characterized by seizures, movement disorders, neurocognitive deficits, and psychosis, but the complete phenotypic heterogeneity, and outcomes are incompletely understood in children.
Alexander J. Sandweiss, Timothy Erickson, Yike Jiang, Varun Kannan, Jonathan M. Yarimi, Kristen S. Fisher, Nikita Shukla, Tim Lotze, Eyal Muscal, Kristy O. Murray   +9 more
wiley   +1 more source

Identifying Cytokine Motif‐Containing, Immunomodulatory Bacterial Proteins in Human Gut Microbiome

Advanced Science, EarlyView.
By building and constructing HMM (Upper left, blue), the authors identify CMCPs in bacteria genomes and CRC related metagenomes and enriched CRC‐related CMCPs (Upper right, blue). They analyze sequence and structural similarity of hits (Lower left, green), test function with engineered EcN delivered to tumors in a mouse tumor model (Lower right, pink ...
Ziyu Wang, Siqi Guo, Jing Li, Qianqian Huang, Jing Ning, Binbin Xia, Xun Lv, Xiang Liu, Zeyu Gao, Jine Li, Longchao Liu, Moshi Song, Jun Wang   +12 more
wiley   +1 more source