Results 71 to 80 of about 108,615 (251)
Outcomes among North American patients with diffuse large B-cell lymphoma are independent of tumor Epstein-Barr virus positivity or immunosuppression
Haematologica, 2018 The prevalence, presenting clinical and pathological characteristics, and outcomes for patients with diffuse large B-cell lymphoma that is Epstein-Barr virus positive remain uncertain as does the impact of congenital or iatrogenic immunosuppression ...Sean I. Tracy, Thomas M. Habermann, Andrew L. Feldman, Matthew J. Maurer, Ahmet Dogan, Usha S. Perepu, Sergei Syrbu, Stephen M. Ansell, Carrie A. Thompson, George J. Weiner, Grzegorz S. Nowakowski, Cristine Allmer, Susan L. Slager, Thomas E. Witzig, James R. Cerhan, Brian K. Link +15 moredoaj +1 more sourceEfficacy of immune checkpoint inhibitors in paediatric, adolescent and young adults with primary refractory or relapsed classical Hodgkin lymphoma: A national multicentre real‐world study
British Journal of Haematology, EarlyView.Summary
Classical Hodgkin lymphoma (cHL) is the most frequent lymphoma in children, adolescents and young adults (CAYA). Despite therapeutic advances, around 15% of patients relapse or have refractory (R/R) disease. Conventional salvage regimens remain effective but are associated with substantial long‐term toxicity. Immune checkpoint inhibitors (CPIs),Marlène Pouthier, Nathalie Garnier, Amaury Leruste, Charlotte Rigaud, Catherine Curtillet, Stéphane Ducassou, Marilyne Poirée, Marie‐Emilie Dourthe, Cécile Pochon, Marie‐Laure Couec, Jacinthe Bonneau‐Lagacherie, Françoise Montravers, Sabah Boudjemaa, Bénédicte Jonca, Stéphanie Haouy, Thierry Leblanc, Judith Landman Parker, Mathieu Simonin +17 morewiley +1 more sourceImmunoprofiling, sex‐ and age‐related determinants of treatment response in paediatric, adolescent and young adult Hodgkin lymphoma
British Journal of Haematology, EarlyView.Multimodal integration of sex‐ and age‐related immune‐gene signatures with baseline tumor burden (TMTV1) improves prediction of treatment response in adolescents and young adults with classical Hodgkin lymphoma. Summary
The study investigates how sex and age influence treatment response in paediatric, adolescent and young adult (AYA) classical Hodgkin ...Valli De Re, Egesta Lopci, Giulia Brisotto, Caterina Elia, Angelo Vitullo, Veronica Paduano, Mariangela De Zorzi, Lara Mussolin, Paola Quarello, Simona Bianchi, Salvatore Buffardi, Alberto Garaventa, Paola Muggeo, Marta Pillon, Alessandra Sala, Luciana Vinti, Emanuele d'Amore, Christine Mauz‐Korholz, Maurizio Mascarin, on behalf of the AIEOP Hodgkin's Lymphoma Study Group, Alberto Garaventa, Alessandra Sala, Antonella Sau, Assunta Tornesello, Daniela Galimberti, Domenico Sperlì, Elena Facchini, Eulalia Galea, Federico Verzegnassi, Fiorina Giona, Francesca Rossi, Fulvio Porta, Irene D’Alba, Katia Perruccio, Luciana Vinti, Marco Zecca, Marta Pillon, Massimo Provenzi, Maurizio Bianchi, Maurizio Mascarin, Monica Cellini, Nadia Vacca, Paola Muggeo, Patrizia Bertolini, Piero Farruggia, Raffaella De Santis, Roberta Pericoli, Rosamaria Mura, Salvatore Buffardi, Salvatore D’Amico, Sayla Bernasconi, Simona Rinieri, Simone Cesaro, Tommaso Casini, Valerio Cecinati +54 morewiley +1 more sourceExpression of Glycoprotein B (gB) Correlates With Poor Prognosis in Nasopharyngeal Carcinoma
Cancer Science, EarlyView.The extent of EBV lytic replication in NPC has not been fully clarified. Our study demonstrated EBV replication and release in NPC and identified a significant association between expression of the late lytic protein gB and poor prognosis. These findings suggest that late lytic gene products may contribute to tumor progression and that gB represents a ...Shigetaka Komura, Satoru Kondo, Hideya Kawasaki, Shinji Watanabe, Satoshi Yamada, Hirotomo Dochi, Han Gia Nguyen, Isao Ohta, Makiko Moriyama‐Kita, Masaki Fukuyo, Kousho Wakae, Yuki Kitagawa, Harue Mizokami, Luyao Liu, Nobuyuki Hirai, Eiji Kobayashi, Takayoshi Ueno, Yosuke Nakanishi, Kazuhira Endo, Hisashi Sugimoto, Naohiro Wakisaka, Rikinari Hanayama, Kiyoshi Misawa, Atsushi Kaneda, Tomokazu Yoshizaki +24 morewiley +1 more sourceEarly‐Onset Digestive System Cancers: Risk Factors and Clinicopathological and Molecular Features Across Organ Sites
Cancer Science, EarlyView.Shared risk factors, clinical features, and tumor characteristics across multiple early‐onset cancer types are shown in this Graphical Abstract. Integrative approaches combining molecular pathology, oncology, and population sciences offer opportunities to clarify underlying mechanisms and help us develop preventive strategies for early‐onset cancers ...Nobuhiro Nakazawa, Satoko Ugai, Atsushi Kondo, Kosuke Matsuda, Shu Kato, Genki Usui, Shiori Tanaka, Hwa‐Young Lee, Xinyuan Zhang, Hideo Miyagawa, Mai Chan Lau, Hiroshi Saeki, Yukihide Kanemitsu, Andrew T. Chan, Shuji Ogino, Minkyo Song, Juha P. Väyrynen, Tomotaka Ugai +17 morewiley +1 more sourcePresenting Clinical Features of Vitreoretinal Lymphoma
Clinical &Experimental Ophthalmology, EarlyView.ABSTRACT Background
Vitreoretinal lymphoma is a rare cancer, widely recognised to present diagnostic challenges. We aimed to report information that would support the clinician in considering this diagnosis. Methods
We interrogated the International Vitreoretinal B‐Cell Lymphoma Registry for clinical data from patients newly diagnosed with ...The International Vitreoretinal B‐Cell Lymphoma Registry Investigator Group, Mara Albert‐Fort, Sofia Androudi, Neni Anggraini, Atitaya Apivatthakakul, J. Fernando Arevalo, Meghan K. Berkenstock, Ester Carreño, Anita S.Y. Chan, Soon‐Phaik Chee, Fred K. Chen, Janejit Choovuthayakorn, Luca Cimino, Elisa E. Cornish, Gábor G. Deák, Alexandra L. Farrall, Christina J. Flaxel, Marion Funk, Zsuzsanna Gehl, Pietro Gentile, Debra A. Goldstein, John A. Gonzales, Fabrizio Gozzi, Antonio Hernández‐Pons, Samar Issa, Timothy M. Janetos, Hyeong Min Kim, Min Kim, Jared E. Knickelbein, Zachary A. Kroeger, Paradee Kunavisarut, Rina La Distia Nora, Seung Min Lee, Lyndell L. Lim, Ming Lee Lin, Victor Llorenç, Yunhua Loo, Lucía Martínez‐Costa, Janet M. Matthews, Peter J. McCluskey, David L. McKay, Matteo Menean, Elisabetta Miserocchi, Manabu Mochizuki, Rachael L. Niederer, Roderick F. O’day, Amy S. Pai, Alan G. Palestine, Kessara Pathanapitoon, Mark H.B. Radford, Josephine Richards, Sukhum Silpa‐archa, Joanne L. Sims, Justine R. Smith, Robert T. Swan, Yukiko Terada, Daniel V. Vasconcelos‐Santos, Anagha Vaze, Samanthila Waduthantri, Travers R.E. Weaver, Keryn L. Williams, Se Joon Woo, Richard J. Woodman, Frances Wu, Christine Younan +64 morewiley +1 more sourceTeplizumab in Stage 2 Type 1 Diabetes: Clinical Practice Experience on Feasibility in 3 Adult Patients
Diabetes, Obesity and Metabolism, EarlyView.ABSTRACT Aim
To describe the first Italian experience with teplizumab administered under a compassionate use programme for adults with Stage 2 type 1 diabetes (T1D), and to evaluate its feasibility, safety and early metabolic outcomes in a real‐life clinical setting outside formal clinical trials.V. Guarnotta, F. Pantò, E. Vigneri, G. Piombo, M. I. Mineo, L. Tomasello, G. Arnaldi +6 morewiley +1 more source
