Results 1 to 10 of about 1,844 (69)

Eptifibatide, an Older Therapeutic Peptide with New Indications: From Clinical Pharmacology to Everyday Clinical Practice

International Journal of Molecular Sciences, 2023
Therapeutic peptides are oligomers or short polymers of amino acids used for various medical purposes. Peptide-based treatments have evolved considerably due to new technologies, stimulating new research interests.
Gašper Tonin, Jasna Klen
semanticscholar   +1 more source

Impact of maintenance dose of eptifibatide in patients with ST-segment elevation myocardial infarction who underwent primary percutaneous coronary intervention

Egyptian Heart Journal, 2023
ST-segment elevation myocardial infarction (STEMI) is usually caused by a rupture in the atherosclerotic plaque, followed by platelet aggregation which ultimately leads to acute coronary artery occlusion.
R. Jalalian, B. Bagheri, Jamshid Yazdani Charati, Shahrnaz Khalaghi, M. Iranian, Mahsa Mohammadi   +5 more
semanticscholar   +1 more source

Combined Approach to Eptifibatide and Thrombectomy in Acute Ischemic Stroke Because of Large Vessel Occlusion: A Matched-Control Analysis

Stroke, 2022
Background: In patients undergoing mechanical thrombectomy (MT), adjunctive antithrombotic might improve angiographic reperfusion, reduce the risk of distal emboli and reocclusion but possibly expose patients to a higher intracranial hemorrhage risk ...
G. Ma, Xuan Sun, Huiran Cheng, W. Burgin, W. Luo, W. Jia, Yajie Liu, Wenlong He, Xiaokun Geng, Liangfu Zhu, Xingyu Chen, Huaizhang Shi, Haowen Xu, Litong Zhang, Anxin Wang, D. Mo, N. Ma, F. Gao, Ligang Song, X. Huo, Yiming Deng, Lian Liu, G. Luo, Baixue Jia, X. Tong, Liping Liu, Zeguang Ren, Z. Miao   +27 more
semanticscholar   +1 more source

Eptifibatide use in ischemic stroke patients undergoing endovascular thrombectomy: A matched cohort analysis

Frontiers in Neurology, 2022
Introduction Small studies have suggested that eptifibatide (EPT) may be safe in acute ischemic stroke (AIS) following intravenous thrombolysis or during endovascular therapy (EVT) for large vessel occlusion (LVO).
Ameena Rana, Siyuan Yu, Savina Reid-Herrera, Scott Kamen, K. Hunter, H. Shaikh, T. Jovin, Olga R Thon, Parth Patel, J. Siegler, Jesse M. Thon   +10 more
semanticscholar   +1 more source

Eptifibatide-Induced Severe Thrombocytopenia After ST-Elevation Myocardial Infarction (STEMI): A Case Report

Cureus, 2022
Eptifibatide is a platelet glycoprotein (GP) IIb/IIIa inhibitor that is used in certain cases of acute coronary syndrome, including those with high thrombus burden or with no-reflow.
Zaid Gheith, Areej Kilani, Tam Nguyen
semanticscholar   +1 more source

Treatment of progressive ischemic stroke with low‑dose eptifibatide: A retrospective case‑control study

Experimental and Therapeutic Medicine, 2022
Progressive ischemic stroke (PIS) is a therapeutic challenge in clinical practice. The present retrospective study aimed to investigate the safety and effectiveness of eptifibatide in the treatment of PIS.
Longfeng Luo, Jinsheng Lin, Ye Deng, Zhigang Li, Ying Yuan, Wen Zhang   +5 more
semanticscholar   +1 more source

A NEW HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY METHOD FOR THE SEPARATION AND SIMULTANEOUS QUANTIFICATION OF EPTIFIBATIDE AND ITS IMPURITIES IN PHARMACEUTICAL INJECTION FORMULATION

International Journal of Applied Pharmaceutics, 2021
Objective: The objective of the present study is to develop a stability-indicating reverse-phase high-performance liquid chromatography (RP-HPLC) method for qualitative and quantitative determination of Eptifibatide and its impurities in bulk and ...
K. S. Girija, Bikshal Babu Kasimala, Venkateswara Rao Anna   +2 more
semanticscholar   +1 more source

Eptifibatide-induced acute profound thrombocytopenia: A case report

Medicine, 2022
Rationale: Eptifibatide is an antiplatelet agent used in the medical management of acute coronary syndrome. Although multiple studies did not reveal a significant association between eptifibatide and the development of thrombocytopenia, recent case ...
Mohammed A. Alamin, A. Al-Mashdali, Dawoud I. Al Kindi, Elkhansa A. Elshaikh, Fahmi Othman   +4 more
semanticscholar   +1 more source

The Pharmacological Effects of Silver Nanoparticles Functionalized with Eptifibatide on Platelets and Endothelial Cells

International Journal of Nanomedicine, 2022
Purpose In the search for new drug delivery platforms for cardiovascular diseases and coating of medical devices, we synthesized eptifibatide-functionalized silver nanoparticles (AgNPs-EPI) and examined the pharmacological activity of AgNPs-EPI on ...
Justyna Hajtuch, E. Iwicka, Anna Szczoczarz, D. Flis, E. Megiel, Piotr Cieciórski, M. Radomski, M. Santos-Martinez, I. Inkielewicz-Stępniak   +8 more
semanticscholar   +1 more source

Eptifibatide bridging therapy for staged carotid artery stenting and cardiac surgery: Safety and feasibility

Vascular, 2022
Background Prophylactic carotid artery stenting (CAS) is an effective strategy to reduce perioperative stroke in patients with severe carotid stenosis who require cardiothoracic surgery (CTS).
M. Caton, K. Narsinh, A. Baker, M. Amans, S. Hetts, J. Rapp, J. Ianuzzi, E. Tseng, W. Gasper, D. Cooke, Travis Caton   +10 more
semanticscholar   +1 more source