Results 41 to 50 of about 5,685 (219)

Early recovery of microvascular perfusion induced by t-PA in combination with abciximab or eptifibatide during postischemic reperfusion

BMC Cardiovascular Disorders, 2002
Background GPIIb/IIIa inhibitors abciximab and eptifibatide have been shown to inhibit platelet aggregation in ischemic heart disease. Our aim was to test the efficacy of abiciximab (Reo Pro) or eptifibatide (Integrilin) alone or in combination with ...
Giusti Andrea, Bertuglia Silva
doaj   +1 more source

Surface modification of polyurethane with eptifibatide-loaded degradable nanoparticles reducing risk of blood coagulation.

Colloids and Surfaces B: Biointerfaces, 2021
The main purpose of the work was to develop a drug releasing coatings on the surface of medical devices exposed to blood flow, what should enable effective inhibition of blood coagulation process.
K. Reczyńska, R. Major, M. Kopernik, E. Pamuła, G. Imbir, H. Plutecka, F. Bruckert, M. Surmiak   +7 more
semanticscholar   +1 more source

How safe is eptifibatide during urgent carotid artery stenting?

Frontiers in Neurology, 2013
Background: Glycoprotein IIB/IIIA inhibitors are occasionally utilized during carotid artery stenting (CAS) in the presence or absence of a visualized intra-operative thrombus. Objective: We assess the hemorrhagic and clinical outcomes associated with
Hesham eAllam, Nirav eVora, Randall eEdgell, Richard Charles Callison, Yasir eAl Khalili, Michelle eStorkan, Amer eAlshekhlee, Amer eAlshekhlee   +7 more
doaj   +1 more source

Association of Ebtifibatide Administration Timing and TIMI Flow of Infarct Related Artery During Primary PCI

Majalah Kardiologi Indonesia, 2013
Background. Optimal administration timing of Glicoprotein IIb/IIIa inhibitor in STEMI patients undergoing Primary PCI is controversial. Several stud -ies have shown that early administration of eptifibatide, which is given to patients with pain awitan of
Abdul Hakim Alkatiri, Yoga Yuniadi, Dicky A Hanafy, Doni Firman, Sunarya Soerianata   +4 more
doaj   +1 more source

A Study of the Impact of Additives on the Physicochemical Properties of Eptifibatide-Loaded Microspheres for Drug Delivery

Journal of Pharmaceutical and BioTech Industry
Poor drug entrapment, burst release, and variable drug release profiles are the most critical challenges associated with biodegradable-polymer-based microspheres. In this study, biodegradable-polymer-based microspheres were used to entrap an antiplatelet
Anand U. Kyatanwar, B. Prabhakar
semanticscholar   +1 more source

An Optimized Scalable Fully Automated Solid-Phase Microwave-Assisted cGMP-Ready Process for the Preparation of Eptifibatide

Organic Process Research & Development, 2020
We investigated several strategies, based on the use of microwave-assisted solid-phase peptide synthesis (MW-SPPS) and scalable to kilogram-scale manufacturing, for the preparation of Eptifibatide,...
G. Sabatino, Annunziata D’Ercole, L. Pacini, M. Zini, A. Ribecai, A. Paio, P. Rovero, A. Papini   +7 more
semanticscholar   +1 more source

Corrections to “An Optimized Safe Process from Bench to Pilot cGMP Production of API Eptifibatide Using a Multigram-Scale Microwave-Assisted Solid-Phase Peptide Synthesizer”

Organic Process Research & Development, 2021
[This corrects the article DOI: 10.1021/acs.oprd.1c00368.].
Annunziata D’Ercole, L. Pacini, G. Sabatino, M. Zini, L. Milli, F. Nuti, A. Ribecai, A. Paio, P. Rovero, A. Papini   +9 more
semanticscholar   +1 more source

Design of termo-sensitive molecularly imprinted polymers(MIP) and in vitro evaluation of controlled release of Eptifibatide drug [PDF]

شیمی کاربردی روز
In this research, a nano polymer was fabricated via the molecular imprinted polymer (MINP) method to transport and control the release of the drug eptifibatide.
Sharif Kaamyabi, Negar Karimi Hajishoreh, Abolfazl Akbarzadeh   +2 more
doaj   +1 more source

Cryo-EM structures of full-length integrin αIIbβ3 in native lipids

Nature Communications, 2023
Platelet integrin αIIbβ3 is maintained in a bent inactive state (low affinity to physiologic ligand), but can rapidly switch to a ligand-competent (high-affinity) state in response to intracellular signals (“inside-out” activation).
Brian D. Adair, Jian-Ping Xiong, Mark Yeager, M. Amin Arnaout   +3 more
doaj   +1 more source

Selective Inhibition of Integrin β3 Topology Provides a Safer Antithrombotic Strategy

Advanced Science, EarlyView.
Current integrin αIIbβ3 inhibitors effectively reduce thrombosis but also increase bleeding risk. During thrombosis, high shear blood flow can directly activate the integrin αIIbβ3 via a distinct topological change in the β3 transmembrane domain, independent of hemostatic platelet signaling.
Joonha Lee, Chul‐Gyun Lim, Pothiappan Vairaprakash, Jong‐Min Kim, Jiyoon Kim, Ji‐Young Park, Klaus M. Hahn, Hyunbo Shim, Hae Woong Choi, Tobias S. Ulmer, Soon Jun Hong, Chungho Kim   +11 more
wiley   +1 more source