Results 51 to 60 of about 5,923 (201)

Comparison between the effect of intracoronary bolus of tirofiban versus eptifibatide as adjunctive antiplatelet therapy on the outcome of primary coronary intervention in patients with acute anterior ST segment elevation myocardial infarction

The Egyptian Heart Journal, 2011
Background: Primary percutaneous coronary intervention (PCI) in patients with acute myocardial infarction (AMI) has been shown to be the preferred reperfusion strategy.
Tarek M. Zaki, Adel Gamal, Walid A. El Hamady, Sherief Mansour, Tamer M. Abu Arab   +4 more
doaj   +1 more source

Inhibition of platelet adhesion, thrombus formation, and fibrin formation by a potent αIIbβ3 integrin inhibitor from ticks

Research and Practice in Thrombosis and Haemostasis, 2021
Background Ticks puncture the skin of their hosts and secrete saliva, containing antiplatelet proteins, into the blood. Here, we studied disagregin, a potent platelet‐inhibiting protein derived from the salivary glands of Ornithodoros moubata, an African
Danique L. van denKerkhof, Magdolna Nagy, Kanin Wichapong, Sanne L.N. Brouns, Johan W. M. Heemskerk, Tilman M. Hackeng, Ingrid Dijkgraaf   +6 more
doaj   +1 more source

Critical Analysis of Thrombocytopenia Associated With Glycoprotein IIb/IIIa Inhibitors and Potential Role of Zalunfiban, a Novel Small Molecule Glycoprotein Inhibitor, in Understanding the Mechanism(s)

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2023
Thrombocytopenia is a rare but serious complication of the intravenous glycoprotein IIb/IIIa (GPIIb/IIIa; integrin αIIbβ3) receptor inhibitors (GPIs), abciximab, eptifibatide, and tirofiban. The thrombocytopenia ranges from mild (50 000–100 000 platelets/
Sem A. O. F. Rikken, Arnoud W. J. van 't Hof, Jurriën M. ten Berg, Dean J. Kereiakes, Barry S. Coller   +4 more
doaj   +1 more source

Association of LDL‐C With Angiographic Thrombus Burden in Patients With ST‐Segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention

Journal of Interventional Cardiology, Volume 2026, Issue 1, 2026.
Background High thrombus burden (HTB) during primary percutaneous coronary intervention (PCI) for ST‐segment elevation myocardial infarction (STEMI) is associated with adverse outcomes. Low‐density lipoprotein cholesterol (LDL‐C) is a key driver of atherosclerosis, but its direct role in acute thrombus formation remains unclear.
Tuo Han, Hytham H. Al-Samawi, Jing Xiao, Xiyu Gao, Gen Liu, Di Bai, Chunyan Zhang, Wei Jiang, Yan Zhang, Irfan Ahmad   +9 more
wiley   +1 more source

Profound thrombocytopenia after primary exposure to eptifibatide

Drug, Healthcare and Patient Safety, 2010
Nicholas B Norgard, Brian T BadgleyUniversity at Buffalo, School of Pharmacy and Pharmaceutical Sciences, Buffalo, NY, USAAbstract: Eptifibatide is a glycoprotein IIb/IIIa receptor antagonist used to reduce the incidence of ischemic events in patients ...
Nicholas B Norgard, Brian T Badgley
doaj  

Platelet glycoprotein IIb/IIIa receptor blockade in coronary artery disease [PDF]

, 2001
Glycoprotein IIb/IIIa inhibitors represent a new promising class of antiplatelet medications. Their use in acute coronary syndromes and for patients undergoing percutaneous coronary intervention has been the subject of a number of large controlled trials
Salam Amar M, Suwaidi Jassim
core   +2 more sources

Repurposing Acebutolol for Osteoporosis Treatment: Insights From Multi‐Omics and Multi‐Modal Data Analysis

Clinical Pharmacology &Therapeutics, Volume 118, Issue 6, Page 1463-1476, December 2025.
Overview of a multi‐omics based drug repurposing strategy. The systematic drug repurposing strategy included the following steps: (1) osteoporosis driver signaling networks were identified from multi‐omics data; (2) drug functional modules were obtained using a network fusion approach to integrate drug similarity information; (3) all drugs were ranked ...
Dan‐Yang Liu, Hui Shen, Jonathan Greenbaum, Qiao‐Rong Yi, Shuang Liang, Yue Zhang, Jia‐Chen Liu, Chuan Qiu, Lan‐Juan Zhao, Qing Tian, Kuan‐Jui Su, Zhe Luo, Li Wu, Xiang‐He Meng, Hong‐Mei Xiao, Yun Deng, Yang Li, Dragana Lovre, Vivian Fonseca, Fernando L. Sanchez, Li‐Jun Tan, Hong‐Wen Deng   +21 more
wiley   +1 more source

Local Intracoronary Eptifibatide versus Mechanical Aspiration in Patients with Acute ST-Elevation Myocardial Infarction

International Journal of Vascular Medicine, 2014
Objectives. We compared local delivery of intracoronary eptifibatide via perfusion catheter to thrombus aspiration in primary PCI. Background. Perfusion catheter increases local concentration of the drugs at the culprit site and prolongs their residency ...
Mohamed A. Hamza, Ayman Galal, Salwa Suweilam, Mohamed Ismail   +3 more
doaj   +1 more source

Platelets stop us leaking [PDF]

, 2016
In this issue of Blood, Welsh and colleagues determine how platelet thrombi limit the loss of plasma-borne proteins from the microvasculature. 1 The concept that platelets prevent leakage from blood vessels following a penetrating injury will come as ...
Bellido-Martín, Falati, Falati, Jonathan M. Gibbins, Law, Stalker, Stalker, Tomaiuolo, van Gestel, Welsh, Welsh   +10 more
core   +1 more source

Safety and efficacy of enoxaparin versus unfractionated heparins in conservatively managed patients with acute coronary syndrome: a systematic review

Journal of Pharmacy Practice and Research, Volume 55, Issue 6, Page 447-457, December 2025.
Abstract Aim Guidelines recommend initial anticoagulant management of acute coronary syndrome (ACS) with low molecular weight heparin (LMWH) such as enoxaparin or unfractionated heparin (UFH). Systematic reviews evaluate early trials in the context of multiple other medications or during percutaneous coronary intervention (PCI) only.
Krishna Doshi, Mark Jones, Laetitia Hattingh   +2 more
wiley   +1 more source