Results 61 to 70 of about 6,731 (217)

Comparison between Bolus Intracoronary versus Bolus Intravenous Injection Regimens of Eptifibatide during Primary Percutaneous Coronary Intervention in Patients with Anterior ST-Segment Elevation Myocardial Infarction

Рациональная фармакотерапия в кардиологии, 2019
Background. Eptifibatide achieves high local concentration via direct intracoronary (I/V) injection as it promotes clot disaggregation, but it remains unclear if it is of superior benefit than the routine intravenous (I/V) administration. Aim.
Mohamed Hassan Nab, Shaimaa Mostafa, Khaled Elrabat, Hamza Kabil, Neama Elmelegy   +4 more
doaj   +1 more source

Intracoronary Versus Intravenous Administration of Eptifibatide During Percutaneous Coronary Intervention in Patients With Acute Coronary Syndromes

Acta Medica Iranica, 2020
Introduction: Platelets activation and aggregation play a major role in thrombosis formation of coronary arteries in patients with Acute Coronary Syndrome (ACS)   and is responsible for most ischemic complications during PCI.
tooran makhdoumi
doaj   +1 more source

Mechanisms of Xenogeneic Baboon Platelet Aggregation and Phagocytosis by Porcine Liver Sinusoidal Endothelial Cells [PDF]

, 2012
Background: Baboons receiving xenogeneic livers from wild type and transgenic pigs survive less than 10 days. One of the major issues is the early development of profound thrombocytopenia that results in fatal hemorrhage.
Buhler, Leo, Csizmad, Eva, Deng, Shaoping, Enjyoj, Keiichi, Lee, Kang Mi, Machaidze, Zurab, Markmann, James, Peng, Qiang, Robson, Simon Christopher, Schuetz, Christian, Wei, Lingling, Yeh, Heidi   +11 more
core   +3 more sources

Diagnosis and Management of Hypersensitivity to Antiplatelet Drugs: EAACI Position Paper

Allergy, Volume 80, Issue 11, Page 2973-2987, November 2025.
ABSTRACT Antiplatelet drug (APD) therapy is the cornerstone for the prevention of atherosclerotic cardiovascular disease. The main APDs are aspirin and thienopyridines, particularly clopidogrel. These drugs may induce hypersensitivity reactions (HSRs).
Gabriele Cortellini, Alla Nakonechna, Annick Barbaud, Sevim Bavbek, Gianfranco Calogiuri, Inmaculada Doña, Violeta Kvedariene, Jose Julio Laguna Martinez, Serena Liberati, Mauro Pagani, Antonino Romano   +10 more
wiley   +1 more source

Clinical and economic studies of eptifibatide in coronary stenting

Therapeutics and Clinical Risk Management, 2014
Tilak Pasala, Prasongchai Sattayaprasert, Pradeep K Bhat, Ganesh Athappan, Sanjay Gandhi The Heart and Vascular Center, Case Western Reserve University/MetroHealth, Cleveland, OH, USA Abstract: Platelet adhesion and aggregation at the site of coronary ...
Pasala T, Sattayaprasert P, Bhat PK, Athappan G, Gandhi S   +4 more
doaj  

Biomimetic Cell Membrane‐Coated Scaffolds for Enhanced Tissue Regeneration

Advanced Materials, Volume 37, Issue 40, October 9, 2025.
This review examines the development and use of cell membrane‐coated scaffolds in tissue engineering. Bioinspired phospholipid and glycocalyx coatings enhance anti‐fouling, anti‐thrombogenic, and selective molecular recognition properties. Native cell membrane coatings further support cell‐specific interactions, immune modulation, and reduced bacterial
Carmen Alvarez‐Lorenzo, Alejandro Ramirez‐Romero, Diana Peixoto, Maria Vivero‐Lopez, Isabel Rodríguez‐Moldes, Angel Concheiro   +5 more
wiley   +1 more source

CLINICAL CASE HISTORY OF EPTIFIBATIDE USE DURING CORONARY INTERVENTION IN PATIENT WITH CORONARY FAILURE

Рациональная фармакотерапия в кардиологии, 2015
Clinical case history of endovascular intervention in infarct related coronary artery with 4 sirolimus-eluting stents implantation and their further thrombosis during early postoperative period is described.
K. A. Kireev, A. V. Krasnopeev, T. S. Kireeva   +2 more
doaj   +1 more source

A Critical Review on BH3 Mimetic Drugs and the Treatment of Cancer‐Associated Thrombosis (CAT): A Proposed Design for a Drug Delivery System Capable of Simultaneously Targeting Tumor Cells and Activated Platelets

Cancer Medicine, Volume 14, Issue 18, September 2025.
Targeting Cancer associated thrombosis (CAT): The left panel (A) shows cancer‐associated thrombosis with activated platelets expressing αIIbβ3 in close contact with tumoral vasculature expressing αvβ3 integrin, where both cells release a significant amount of thrombin.
Mehran Ghasemzadeh, Nazanin Heidari, Jalal Naghinezhad, Alireza Ghasemzadeh, Ehteramolsadat Hosseini   +4 more
wiley   +1 more source

The Effectiveness and Safety of Adjuvant Therapy with t-PA in Acute Ischemic Stroke: A Systematic Review and Network Meta-Analysis

Journal of Clinical Question
Introduction: Acute ischemic stroke (AIS) is a leading cause of disability and death worldwide. While tissue plasminogen activator (t-PA) remains a cornerstone of treatment, its efficacy is limited by risks such as intracranial hemorrhage (ICH).
Xiaoju Zhen, Meng Zhao, Toshiyuki Kawashima   +2 more
doaj   +1 more source

The chaperone protein HSP47: a platelet collagen binding protein that contributes to thrombosis and haemostasis [PDF]

, 2018
Objective: Heat shock protein 47 (HSP47) is an intracellular chaperone protein that is vital for collagen biosynthesis in collagen secreting cells. This protein has also been shown to be present on the surface of platelets.
AlOuda, K. S., Bye, A. P., Farndale, R. W., Gibbins, J. M., Holbrook, L. M., Kaiser, W. J., Kriek, N., Nagata, K., Sage, T., Sasikumar, P., Unsworth, A. J., Ushioda, R. W.   +11 more
core   +2 more sources