Results 71 to 80 of about 6,731 (217)

Evaluation of CYP2C19 Clinical Decision Support Alerts to Guide P2Y12 Inhibitor Prescribing

Clinical Pharmacology &Therapeutics, Volume 118, Issue 2, Page 470-479, August 2025.
P2Y12 inhibitor selection involves numerous factors, including CYP2C19 genetics, since evidence demonstrates reduced clopidogrel efficacy in patients with decreased or no function CYP2C19 variants. In 2020, Indiana University health embedded interruptive clinical decision support (CDS) alerts in the electronic health record (EHR) to recommend ...
Ashley N. Springer, Leah A. Alicea, Yemi Gafari, Tayler B. Smith, Sheryl Lynch, Amy M. Breman, Jennelle C. Hodge, Victoria M. Pratt, Nicholas R. Powell, Rolf P. Kreutz, Daniel P. Kobold, Michael T. Eadon, Emma M. Tillman, Tyler Shugg, Todd C. Skaar   +14 more
wiley   +1 more source

Immediate outcomes of eptifibatide therapy during intracoronary stent implantation

Advanced Biomedical Research, 2016
Background: The objective of the present study was to assess the major immediate outcomes of eptifibatide therapy during intracoronary stent implantation.
Hooman Shariati, Hamid Sanei, Ali Pourmoghadas, Leila Salehizadeh, Afshin Amirpour   +4 more
doaj   +1 more source

Platelets stop us leaking [PDF]

, 2016
In this issue of Blood, Welsh and colleagues determine how platelet thrombi limit the loss of plasma-borne proteins from the microvasculature. 1 The concept that platelets prevent leakage from blood vessels following a penetrating injury will come as ...
Bellido-Martín, Falati, Falati, Jonathan M. Gibbins, Law, Stalker, Stalker, Tomaiuolo, van Gestel, Welsh, Welsh   +10 more
core   +1 more source

High‐throughput screen identifies MAS9 as a novel inhibitor of the C‐type lectin receptor‐2 (CLEC‐2)–podoplanin interaction

British Journal of Pharmacology, Volume 182, Issue 16, Page 3838-3851, August 2025.
Abstract Background and Purpose The C‐type lectin‐like receptor‐2 (CLEC‐2) is a platelet receptor for the endogenous ligand podoplanin. This interaction contributes to several (patho)physiological processes, such as lymphangiogenesis, preservation of blood and lymphatic vessel integrity organ development, and tumour metastasis.
Marcin A. Sowa, Yan Wu, Jan van Groningen, Ying Di, Helma van den Hurk, Johannes A. Eble, Jonathan M. Gibbins, Ángel García, Alice Y. Pollitt   +8 more
wiley   +1 more source

Pharmacotherapy of Acute Coronary Syndromes: Medical Economics with an Emphasis on Clopidogrel [PDF]

, 2018
Summary: Acute coronary syndromes account worldwide for a significant burden of hospital- and societal costs. Pharmacotherapy of acute coronary syndromes consists of a combined antithrombotic therapy.
Bramkamp, Matthias, Dedes, Konstantin, Szucs, Thomas   +2 more
core  

Assessing a 600-mg Loading Dose of Clopidogrel 24 Hours Prior to Pipeline Embolization Device Treatment [PDF]

, 2018
Background: Clopidogrel/aspirin antiplatelet therapy routinely is administered 7-10 days before pipeline aneurysm treatment. Our study assessed the safety and efficacy of a 600-mg loading dose of clopidogrel 24 hours before Pipeline Embolization Device ...
Atallah, MD, Elias, Bekelis, MD, Kimon, Chalouhi, MD, Nohra, Hasan, MD, David, Jabbour, Pascal, MD, Rosenwasser, MD, MBA, FACS, FAHA, Robert H., Saad, MD, Hassan, Smith, MD, Michelle, Tjoumakaris, MD, Stavropoula, Zarzour, MD, Hekmat   +9 more
core   +2 more sources

Eptifibatide use in ischemic stroke patients undergoing endovascular thrombectomy: A matched cohort analysis [PDF]

, 2022
Ameena Rana, Siyuan Yu, Savina Reid-Herrera, Scott Kamen, Krystal Hunter, Hamza Shaikh, Tudor G. Jovin, Olga R. Thon, Parth Patel, James E. Siegler, Jesse Thon   +10 more
openalex   +1 more source

First Phosphonic‐Type Inhibitors and Activity‐Based Probes Specific to the O'nyong‐nyong Virus Capsid Protease

ChemMedChem, Volume 20, Issue 12, June 17, 2025.
The serine capsid protease (CP) catalyzes a crucial process of the alphaviral replication cycle; therefore, it constitutes an interesting therapy target. Herein, the O'nyong‐nyong virus CP profile activity with a specific fluorogenic substrate is analyzed and examines the inhibitory activity of a new series of phosphonic analogs of tryptophan and ...
Karolina Torzyk‐Jurowska, Agnieszka Łupicka‐Słowik, Renata Grzywa, Yuliya Chykunova, Krzysztof Pyrć, Marcin Sieńczyk   +5 more
wiley   +1 more source

A disintegrin derivative as a case study for PHIP labeling of disulfide bridged biomolecules

Scientific Reports, 2022
A specific labeling strategy for bioactive molecules is presented for eptifibatide (integrilin) an antiplatelet aggregation inhibitor, which derives from the disintegrin protein barbourin in the venom of certain rattlesnakes. By specifically labeling the
Max Fleckenstein, Kevin Herr, Franziska Theiß, Stephan Knecht, Laura Wienands, Martin Brodrecht, Michael Reggelin, Gerd Buntkowsky   +7 more
doaj   +1 more source

Successful Aspiration Thrombectomy for Cocaine‐Induced Right Coronary Artery Embolism Secondary to Left Ventricular Thrombus: A Case Report and Literature Review

Clinical Case Reports, Volume 13, Issue 5, May 2025.
ABSTRACT Coronary embolism (CE) is a rare yet significant contributor to acute myocardial infarction (AMI), particularly in younger patients. We report a 42‐year‐old male who experienced an AMI following recent cocaine use. Investigations revealed a left ventricular apical thrombus, identified as the source of a distal embolus occluding the right ...
Abraam Rezkalla, Ahmad Nouri, Fadi Hadya, Islam Rajab, Emile Doss   +4 more
wiley   +1 more source