Results 71 to 80 of about 6,458 (228)

A disintegrin derivative as a case study for PHIP labeling of disulfide bridged biomolecules

Scientific Reports, 2022
A specific labeling strategy for bioactive molecules is presented for eptifibatide (integrilin) an antiplatelet aggregation inhibitor, which derives from the disintegrin protein barbourin in the venom of certain rattlesnakes. By specifically labeling the
Max Fleckenstein, Kevin Herr, Franziska Theiß, Stephan Knecht, Laura Wienands, Martin Brodrecht, Michael Reggelin, Gerd Buntkowsky   +7 more
doaj   +1 more source

Assessing a 600-mg Loading Dose of Clopidogrel 24 Hours Prior to Pipeline Embolization Device Treatment [PDF]

, 2018
Background: Clopidogrel/aspirin antiplatelet therapy routinely is administered 7-10 days before pipeline aneurysm treatment. Our study assessed the safety and efficacy of a 600-mg loading dose of clopidogrel 24 hours before Pipeline Embolization Device ...
Atallah, MD, Elias, Bekelis, MD, Kimon, Chalouhi, MD, Nohra, Hasan, MD, David, Jabbour, Pascal, MD, Rosenwasser, MD, MBA, FACS, FAHA, Robert H., Saad, MD, Hassan, Smith, MD, Michelle, Tjoumakaris, MD, Stavropoula, Zarzour, MD, Hekmat   +9 more
core   +2 more sources

Association of Anaesthetists guidelines: the use of blood components and their alternatives

Anaesthesia, Volume 80, Issue 4, Page 425-447, April 2025.
Summary Background The administration of blood components and their alternatives can be lifesaving. Anaemia, bleeding and transfusion are all associated with poor peri‐operative outcomes. Considerable changes in the approaches to optimal use of blood components and their alternatives, driven by the findings of large randomised controlled trials and ...
Akshay Shah, Andrew A. Klein, Seema Agarwal, Andrew Lindley, Aamer Ahmed, Kerry Dowling, Emma Jackson, Sumit Das, Divya Raviraj, Rachel Collis, Anna Sharrock, Simon J. Stanworth, Paul Moor   +12 more
wiley   +1 more source

Platelets induce apoptosis during sepsis in a contact-dependent manner that is inhibited by GPIIb/IIIa blockade. [PDF]

PLoS ONE, 2012
PurposeEnd-organ apoptosis is well-described in progressive sepsis and Multiple Organ Dysfunction Syndrome (MODS), especially where platelets accumulate (e.g. spleen and lung).
Matthew Sharron, Claire E Hoptay, Andrew A Wiles, Lindsay M Garvin, Mayya Geha, Angela S Benton, Kanneboyina Nagaraju, Robert J Freishtat   +7 more
doaj   +1 more source

Microfluidic thrombosis under multiple shear rates and antiplatelet therapy doses. [PDF]

PLoS ONE, 2014
The mainstay of treatment for thrombosis, the formation of occlusive platelet aggregates that often lead to heart attack and stroke, is antiplatelet therapy. Antiplatelet therapy dosing and resistance are poorly understood, leading to potential incorrect
Melissa Li, Nathan A Hotaling, David N Ku, Craig R Forest   +3 more
doaj   +1 more source

Mechanisms of Xenogeneic Baboon Platelet Aggregation and Phagocytosis by Porcine Liver Sinusoidal Endothelial Cells [PDF]

, 2012
Background: Baboons receiving xenogeneic livers from wild type and transgenic pigs survive less than 10 days. One of the major issues is the early development of profound thrombocytopenia that results in fatal hemorrhage.
Buhler, Leo, Csizmad, Eva, Deng, Shaoping, Enjyoj, Keiichi, Lee, Kang Mi, Machaidze, Zurab, Markmann, James, Peng, Qiang, Robson, Simon Christopher, Schuetz, Christian, Wei, Lingling, Yeh, Heidi   +11 more
core   +3 more sources

Impact of bridging thrombolysis versus endovascular thrombectomy alone on outcomes in anticoagulated patients with atrial fibrillation and acute ischaemic stroke

European Journal of Neurology, Volume 31, Issue 12, December 2024.
Abstract Background and purpose The impact of bridging thrombolysis prior to endovascular thrombectomy (EVT) compared to EVT alone on intracerebral haemorrhage (ICH), subarachnoid haemorrhage (SAH), and death in anticoagulated atrial fibrillation (AF) patients with acute ischaemic stroke (AIS) is not well defined.
Muath Alobaida, Stephanie L. Harrison, Deirdre A. Lane, Fiona Rowe, Philip Austin, Azmil H. Abdul‐Rahim, Gregory Y. H. Lip   +6 more
wiley   +1 more source

Platelet aggregation inhibition by Eptifibatide versus high dose Tirofiban during primary percutaneous interventions

The Egyptian Heart Journal, 2014
Background: Platelet aggregation occurs as a central role in acute coronary syndrome (ACS), and glycoprotein GP IIb/IIIa inhibitors may enhance the benefits expected from early recanalisation. Aim: To compare the degree of platelet aggregation inhibition
Yasser Sadek Nassar, Mohamed Laimud, Mohamed Afify, Mohamed Ashraf Shawky   +3 more
doaj   +1 more source

Potentiation of thrombus instability: a contributory mechanism to the effectiveness of antithrombotic medications [PDF]

, 2018
© The Author(s) 2018The stability of an arterial thrombus, determined by its structure and ability to resist endogenous fibrinolysis, is a major determinant of the extent of infarction that results from coronary or cerebrovascular thrombosis.
A Gast, AD Michelson, B Labarthe, B Shen, C Patrono, CT Ammollo, D Capodanno, D Gailani, DA Gorog, Diana A. Gorog, DM Coenen, E Álvarez, ER Bates, F Kabirian, F Müller, F Semeraro, G Stephens, H Brogren, HE Speich, HE Speich, HJ Weiss, HJ Weiss, HR Baumgartner, J Zilberman-Rudenko, JD McFadyen, JI Weitz, JM Cosemans, JP Collet, JP Collet, K Hosokawa, K Nagatsuka, KS Sakariassen, L Valerio, LF Brass, M Cattaneo, M Farag, M Humbert, M Larsson, M Li, M Ungerer, MA Bailey, MI Furman, MJ Price, ML Montfoort von, MS Sabatine, P Andre, P Seizer, PA Borne von dem, PP Wadowski, R Hellmuth, R Nergiz-Unal, RA Ajjan, S Goto, S Goto, SA Shaya, SB Larsen, SJ Marciniak, T Heitzer, T Renné, VT Turitto, VT Turitto, WA Schumacher, WS Nesbitt, X Wang, Y Yano, YC Lau, ZM Ruggeri   +66 more
core   +2 more sources

Before, during, and after: An Argument for Safety and Improved Outcome of Thrombolysis in Acute Ischemic Stroke with Direct Oral Anticoagulant Treatment

Annals of Neurology, Volume 96, Issue 5, Page 871-886, November 2024.
Clinicians fear thrombolysis after direct oral anticoagulant (DOAC) use due to experience with warfarin. In contrast to vitamin K antagonists such as warfarin, DOACs prevent thrombosis by blocking thrombin. Clinical observational data suggest that thrombolysis may be safe in the setting of DOAC use.
Sanaz Monjazeb, Heather V. Chang, Patrick D. Lyden   +2 more
wiley   +1 more source