Results 81 to 90 of about 8,424 (263)
A critical appraisal of platelet glycoprotein IIb/IIIa inhibition [PDF]
, 2000 Despite the success of abciximab in preventing ischemic events after percutaneous coronary interventions, attempts to develop intravenous, small-molecule glycoprotein IIb/IIIa antagonists and diversify the clinical indications for these agents have ...
Chew, Derek P, Moliterno, David J
core +1 more source
Association of Anaesthetists guidelines: the use of blood components and their alternatives
Anaesthesia, Volume 80, Issue 4, Page 425-447, April 2025.Summary Background The administration of blood components and their alternatives can be lifesaving. Anaemia, bleeding and transfusion are all associated with poor peri‐operative outcomes. Considerable changes in the approaches to optimal use of blood components and their alternatives, driven by the findings of large randomised controlled trials and ...
Akshay Shah +12 more
wiley +1 more source
Immediate outcomes of eptifibatide therapy during intracoronary stent implantation
Advanced Biomedical Research, 2016 Background: The objective of the present study was to assess the major immediate outcomes of eptifibatide therapy during intracoronary stent implantation.
Hooman Shariati +4 more
doaj +1 more source
Organic Process Research & Development, 2020 We investigated several strategies, based on the use of microwave-assisted solid-phase peptide synthesis (MW-SPPS) and scalable to kilogram-scale manufacturing, for the preparation of Eptifibatide,...
G. Sabatino +7 more
semanticscholar +1 more source
A disintegrin derivative as a case study for PHIP labeling of disulfide bridged biomolecules
Scientific Reports, 2022 A specific labeling strategy for bioactive molecules is presented for eptifibatide (integrilin) an antiplatelet aggregation inhibitor, which derives from the disintegrin protein barbourin in the venom of certain rattlesnakes. By specifically labeling the
Max Fleckenstein +7 more
doaj +1 more source
Platelets promote macrophage polarization toward pro-inflammatory phenotype and increase survival of septic mice [PDF]
, 2019 We investigated the contribution of human platelets to macrophage effector properties in the presence of lipopolysaccharide (LPS), as well as the beneficial effects and time frame for platelet transfusion in septic animals.
Carestia, Agostina +9 more
core +1 more source
European Journal of Neurology, Volume 31, Issue 12, December 2024.Abstract Background and purpose The impact of bridging thrombolysis prior to endovascular thrombectomy (EVT) compared to EVT alone on intracerebral haemorrhage (ICH), subarachnoid haemorrhage (SAH), and death in anticoagulated atrial fibrillation (AF) patients with acute ischaemic stroke (AIS) is not well defined.
Muath Alobaida +6 more
wiley +1 more source
Рациональная фармакотерапия в кардиологии, 2020 Recently, there has been a positive trend to reduce mortality from myocardial infarction. One of the reasons for such dynamics is the development of angiographic service in our country and the increase in the number of primary percutaneous coronary ...
A. S. Tereshchenko +2 more
doaj +1 more source
Platelets induce apoptosis during sepsis in a contact-dependent manner that is inhibited by GPIIb/IIIa blockade. [PDF]
PLoS ONE, 2012 PurposeEnd-organ apoptosis is well-described in progressive sepsis and Multiple Organ Dysfunction Syndrome (MODS), especially where platelets accumulate (e.g. spleen and lung).
Matthew Sharron +7 more
doaj +1 more source
Annals of Neurology, Volume 96, Issue 5, Page 871-886, November 2024.Clinicians fear thrombolysis after direct oral anticoagulant (DOAC) use due to experience with warfarin. In contrast to vitamin K antagonists such as warfarin, DOACs prevent thrombosis by blocking thrombin. Clinical observational data suggest that thrombolysis may be safe in the setting of DOAC use.
Sanaz Monjazeb +2 more
wiley +1 more source