Results 91 to 100 of about 18,864 (234)

A Nano‐Interception Strategy for Chronic Heart Failure: Prussian Blue Nanoparticles Disrupt Fibroblast‐Immune Communication via CCL2 Sequestration

Advanced Materials, EarlyView.
A nano‐interception strategy disrupts pathogenic fibroblast–macrophage crosstalk in chronic heart failure. Scalable Prussian blue nanoparticles selectively sequester CCL2 via ultrahigh‐affinity binding, preventing CCR2+ macrophage recruitment and breaking a key fibro‐inflammatory circuit. This approach demonstrates robust efficacy in murine and porcine
Bo Chen, Gao Wei, Guowei Zeng, Haoyu Li, Rongrong Wu, Hongyu Yan, Zijie Zhou, Kai Luo, Xiaoyang Zhang, Cong Li, Longming Huang, Lingyan Cheng, Xinjie Zhang, Jinghao Zheng, Bozhong Shi, Xiaojun Cai, Xiaomin He   +16 more
wiley   +1 more source

Generating EQ-5D-3L Utility Scores from the Dermatology Life Quality Index:A Mapping Study in Patients with Psoriasis

, 2018
OBJECTIVES: To develop an algorithm to predict the three-level EuroQol five-dimensional questionnaire (EQ-5D-3L) utility scores from the Dermatology Life Quality Index (DLQI) in psoriasis.METHODS: This mapping study used data from the British Association

core   +4 more sources

Health related quality of life among pregnant women living with HIV in Kenya, results from comparing a patient generated index and the Euroqol 5 dimension 3 level

BMC Women's Health, 2022
Background Standardized tools are used to measure health-related quality of life (HRQoL) and they focus on selected physical, emotional, and social functioning. This approach may miss out on the heterogeneity of HRQoL among various sub-populations.
Jonathan Mwangi, Laura Ternent, Patricia Opondo Awiti Ujiji, Edwin Were, Anna Mia Ekström   +4 more
doaj   +1 more source

Matrix Viscoelasticity Regulates Dendritic Cell Migration and Immune Priming

Advanced Materials, EarlyView.
Matrix viscoelasticity is a key mechanical feature of the tumor microenvironment but remains poorly understood in immune regulation. Here, we develop a tunable collagen platform to decouple viscoelasticity from stiffness and show that slow‐relaxing matrices constrain dendritic cell migration by limiting actomyosin‐driven matrix remodeling, thereby ...
Wei‐Hung Jung, Emie Humann, Joshua M. Price, Yoav Binenbaum, Azra Haseki, Sanjana Iyer, David J. Mooney   +6 more
wiley   +1 more source

Spironolactone for People Age 70 Years and Older With Osteoarthritic Knee Pain:A Proof‐of‐Concept Trial [PDF]

, 2016
Objective: To determine whether spironolactone could benefit older people with osteoarthritis (OA), based on a previous study showing that spironolactone improved quality of life. Methods: This parallel-group, randomized, placebo-controlled, double-blind
Argo, Ishbel, Cvoro, Vera, Donnan, Peter T., Littleford, Roberta, McMurdo, Marion E. T., Rauchhaus, Petra, Struthers, Allan D., Sumukadas, Deepa, Waldie, Helen, Witham, Miles D.   +9 more
core   +1 more source

Multimodal Haptic Perception Through Synergistic Nanocomposite Sensor Arrays

Advanced Materials Technologies, EarlyView.
Multi‐modal fingertip haptics are advanced through a bioinspired &vertical‐via' electronic skin architecture. A confined PDMS/MWCNT/NiNP nanocomposite, sitting at the percolation threshold, enables tactile, thermal, and magnetic sensing. A unique via‐density gradient and dedicated &Un‐Touch' reference nodes provide robust spatial resolution and signal ...
Amos Bardea, Fernando Patolsky
wiley   +1 more source

The societal monetary value of a QALY associated with EQ-5D-3L health gains [PDF]

The European Journal of Health Economics, 2019
There is an extensive body of empirical research that focuses on the societal monetary value of a quality-adjusted life year (MVQALY). Many of these studies have found the estimates to be inversely associated with the size of the health gain, and thus not conforming to the linearity assumption imposed in the QALY model.
Vallejo-Torres, L, García-Lorenzo, B, Rivero-Arias, O, Pinto-Prades, J   +3 more
openaire   +4 more sources

Convergent and discriminative validity of the Frail-VIG index with the EQ-5D-3L in people cared for in primary health care [PDF]

, 2021
Background The Frail-VIG frailty index has been developed recently. It is an instrument with a multidimensional approach and a pragmatic purpose that allows rapid and efficient assessment of the degree of frailty in the context of clinical practice.
Amblàs-Novellas, Jordi, Gea Caballero, Vicente, Julián Rochina, Iván, Pérez Tortajada, Gemma, Zabaleta-del-Olmo, Edurne, Zamora-Sánchez, Juan José   +5 more
core   +4 more sources

CDK4/6 Inhibition Induces CD8+ T Cell Antitumor Immunity via MIF‐Induced Functional Orchestration of Tumor‐Associated Macrophages

Advanced Science, EarlyView.
CDK4/6 inhibition promotes CD8+ T cell expansion through tumor‐macrophage crosstalk by activating HIF‐1α and enhancing MIF‐CD44/CD74 signaling. This reprograms TAMs to boost MHC‐I antigen presentation, and CDK4/6 inhibitor‐trained M1 TAM supernatant therapy synergizes with low‐dose PD‐1 blockade to restore antitumor immunity.
Lin He, Yuzhong Peng, Lat‐lun Leong, Jingbo Zhou, Dongyang Tang, Weilu Wang, Xiaoran Wu, Josh haipeng Lei, Yongqin Ye, Yangyang Feng, Yunfeng Qiao, Xiangpeng Chu, Di Mu, Qi Zhao, Tzuming Liu, Yan Chen, Paul Kwonghang Tam, Chu‐Xia Deng   +17 more
wiley   +1 more source

Five-year follow-up results of the PROFHER trial comparing operative and non-operative treatment of adults with a displaced fracture of the proximal humerus [PDF]

, 2017
AIMS: The PROximal Fracture of the Humerus Evaluation by Randomisation (PROFHER) randomised clinical trial compared the operative and non-operative treatment of adults with a displaced fracture of the proximal humerus involving the surgical neck. The aim
Billingham LJ, Chen Z, Corbacho B, Dawson J, Dawson J, Handoll H, Handoll H, Handoll HH, Hodgson SA, Neer CS II, Peters SA, Rangan A   +11 more
core   +3 more sources