Results 101 to 110 of about 18,864 (234)

Mapping the Beck Depression Inventory to the Eq-5d-3l in Patients with Depressive Disorders [PDF]

Value in Health, 2015
For cost-utility analyses, data on health state utilities, as provided by the EQ-5D-3L, is needed but not always available. This study specified mapping algorithms from the Beck Depression Inventory (BDI) index to the EQ-5D-3L index adjusted for specific socio-demographic variables for patients with depressive disorders.The objective of this study was ...
Grochtdreis, T, Brettschneider, C, Hajek, A, Schierz, K, Hoyer, J, König, H   +5 more
openaire   +2 more sources

GATA4‐Driven Transcription of HtrA1 Promotes Cellular Senescence in Ménière's Disease and Age‐Related Audio‐Vestibular Dysfunction

Advanced Science, EarlyView.
This study identifies the HDAC6/GATA4/HtrA1 axis as a critical driver of cellular senescence in the inner ear. GATA4 nuclear translocation, facilitated by HDAC6 downregulation, transcriptionally activates HtrA1, promoting hair cell senescence, SASP, and audio‐vestibular dysfunction in models of Ménière's disease and age‐related audio‐vestibular ...
Na Zhang, Na Li, Yan Wang, Jing Zhang, Jiahui Liu, Lei Chen, Yongdong Song, Yurong Mu, Yuechen Han, Yafeng Lyu, Xiaofei Li, Hanyue Wang, Jing Wang, Yao Lu, Zhaomin Fan, Daogong Zhang, Haibo Wang   +16 more
wiley   +1 more source

Validity of the EQ-5D-5L and EQ-5D-3L in patients with Crohn’s disease [PDF]

Quality of Life Research, 2018
The EuroQol five-dimension questionnaire (EQ-5D) is the most commonly used instrument to obtain utility values for cost-effectiveness analyses of treatments for Crohn's disease (CD). We aimed to compare the measurement properties of the two adult versions of EQ-5D (EQ-5D-3L and EQ-5D-5L) in patients with CD.Between 2016 and 2017, a multicentre cross ...
Fanni Rencz, Peter L. Lakatos, László Gulácsi, Valentin Brodszky, Zsuzsanna Kürti, Szilvia Lovas, János Banai, László Herszényi, Tamás Cserni, Tamás Molnár, Márta Péntek, Károly Palatka   +11 more
openaire   +3 more sources

TRMT6‐Mediated m1A Modification of CDK9 mRNA Is a Dual‐Pronged Pathogenic Driver for HBV‐Related Hepatocellular Carcinoma

Advanced Science, EarlyView.
TRMT6‐mediated m1A modification in CDK9 mRNA enhances its mRNA stability and translation efficiency, thereby increasing the protein levels of CDK9. Upregulated CDK9 promotes the progression of HCC by elevating the levels of oncogenic factors including p‐STAT3, MCL1, and BCL‐2. On the other hand, CDK9 phosphorylates TARDBP at Ser254 to activate HBV core
Rui Zhang, Dandan Zong, Rui Liu, Yubo Wang, Qingqing Gu, Yao Yao, Wenfang Zheng, Mengmeng Yuan, Simeng Wang, Rongrong Cui, Daxu Li, Siwen Dang, Peng Hou   +12 more
wiley   +1 more source

Convergent validity of the EQ-5D-3L in a randomized-controlled trial of the Housing First model

BMC Health Services Research, 2019
Background Health utility assessments are important for economic evaluations but few instruments have been validated in homeless people with mental illness.
Nicole Kozloff, Andrew D. Pinto, Vicky Stergiopoulos, Stephen W. Hwang, Patricia O’Campo, Ahmed M. Bayoumi   +5 more
doaj   +1 more source

Crosswalk EQ-5D-5L Value Set for Slovenia

Slovenian Journal of Public Health, 2020
Due to the availability of the EQ-5D-5L instrument official translation into Slovenian its use is widespread in Slovenia. However, the health profiles obtained in many studies cannot be ascribed their appropriate values as the EQ-5D-5L value set does not
Prevolnik Rupel Valentina, Ogorevc Marko
doaj   +1 more source

Validity and reliability of the EQ-5D-3L™ among a paediatric injury population [PDF]

Health and Quality of Life Outcomes, 2013
The purpose of this study was to determine the construct validity of the EQ-5D-3L™ for use among a population of injured young people and to examine the reliability of different modes of administration including paper and pencil, online and telephone. Methods: In total, 345 participants (aged 0 – 16) were recruited from a paediatric hospital in a large
Brussoni, Mariana, Kruse, Sami, Walker, Kerry   +2 more
openaire   +2 more sources

A Nanoparticle‐Integrated Complete Manufacturing Pipeline of Chemically Engineered Exosomes

Advanced Science, EarlyView.
We report a novel manufacture technology of chemically engineered exosomes. The four steps of manufacturing, i.e., biogenesis, loading, isolation, and storage, are integrated by the use of a nanoparticle. The manufacture technology incorporates three innovative components, i.e., a new nano‐bio effect, a new composite nanoparticle, and a new isolation ...
Xiaowei Wen, Zixing Xu, Zerun Hao, Yanming Chen, Kai Xie, Haofan Yin, Xueying Wang, Jie Min, Sihan Sun, Baiding Chen, Chengxiu Ling, Mingming Xu, Yizhao Chen, Gang Ruan   +13 more
wiley   +1 more source

Weather sensitivity associated with quality of life in patients with fibromyalgia

BMC Rheumatology, 2021
Background Fibromyalgia is characterized by chronic widespread pain, and more than half of patients with fibromyalgia report that weather-related variables aggravate their symptoms.
Kazuhiro Hayashi, Kenji Miki, Noriyuki Hayashi, Ryota Hashimoto, Masao Yukioka   +4 more
doaj   +1 more source

EQ-5D-5L versus 3L: the impact on cost-effectiveness [PDF]

, 2017
Objectives To model the relationship between EQ-5D-3L and EQ-5D-5L and examine how differences impact on cost-effectiveness in case studies. Methods We used two datasets that included both EQ-5D-3L and EQ-5D-3L from the same respondents.
Barton, G., Gomes, M., Grimm, S., Hernandez Alava, M., Irvine, L., Meads, D., O'Dwyer, J., Pudney, S., Sadique, Z., Wailoo, A.J.   +9 more
core