Results 121 to 130 of about 9,127 (183)

Anterior cingulate cortex neuron subtypes differentially regulate seizures

Epilepsia, EarlyView.
Abstract Objective This study aimed to investigate the regulatory roles of distinct neuronal subtypes within the anterior cingulate cortex (ACC) in acute seizures and to identify cell type‐specific mechanisms underlying seizure modulation in this region. Methods Acute seizure models were established in mice via pentylenetetrazol injection.
Ziqian Yan, Ting Tang, Kaishan Wang, Bin Fu, Zesheng Li, Mingshan Liu, Hongyi Huang, Yanfeng Yang, Qiang Zheng, Yangmin Zheng, Yongzhi Shan, Yumin Luo, Guoguang Zhao   +12 more
wiley   +1 more source

Developing mapping algorithms to predict EQ-5D health utility values from Bath Ankylosing Spondylitis Disease Activity Index and Bath Ankylosing Spondylitis Functional Index among patients with Ankylosing Spondylitis

Health and Quality of Life Outcomes
Background Preference-based measures of health-related quality of life (HRQoL), such as the EQ-5D or the SF-6D, are essential for health economic evaluation. However, they are rarely included in clinical trials of ankylosing spondylitis (AS).
Lingjia Yu, Huizhi Yang, Liyong Lu, Yingying Fang, Xianyu Zhang, Shunping Li, Chaofan Li   +6 more
doaj   +1 more source

Treatment‐Related Adverse Events and Health‐Related Quality of Life Associated With Immune Checkpoint Inhibitor Treatment for Mucosal Head and Neck Squamous Cell Carcinoma: A Scoping Review

Head &Neck, EarlyView.
ABSTRACT Background Supportive care needs of patients receiving immune checkpoint inhibitors (ICIs) for head and neck squamous cell carcinoma (HNSCC) are ill‐defined. Hence, known treatment‐related adverse events (TRAEs) and health‐related quality of life (HRQoL) associated with ICI treatment for HNSCC were examined to inform future supportive care ...
N. D. O'Donnell, E. C. Ward, L. R. Wishart, R. Perera, C. Barrett, K. A. Edmiston, E. Mitchell, A. Pigott, R. Pitt, K. Russell, B. A. Chan, R. Ladwa   +11 more
wiley   +1 more source

Holistic bone developing microenvironment engineered apoptotic extracellular vesicles recapitulate multidimensional developmental signatures in adult and senile bone repair

Interdisciplinary Medicine, EarlyView.
The developing bone was identified as an M2a‐like macrophage driven immune microenvironment with multidimensional developmental signatures. hME‐ApoEVs were successfully fabricated via stimulating the M2a‐like developing microenvironment in vitro and confirmed its recapitulation of developmental features.
Xiaoran Yu, Jieyun Xu, Yuan Zhao, Xinyu Guo, Hongcheng Chen, Junlong Xue, Yong Ao, Linjun Zhang, Xiaomeng Gao, Xueli Mao, Songtao Shi, Zetao Chen   +11 more
wiley   +1 more source

Health-state utility values and their time to deterioration in informal caregivers of older patients with chronic diseases

Frontiers in Public Health
ObjectivesThis study aimed to assess health state utility values (HSUVs) in caregivers of older patients with chronic diseases receiving or not receiving social worker support.MethodsThis multicentric open-label randomized study assigned caregivers to ...
Astrid Pozet, Antoine Falcoz, Cécile Roller, Taha Jai, Aurelia Meurisse, Virginie Nerich   +5 more
doaj   +1 more source

Patients with previous anterior cruciate ligament reconstruction achieve equally good outcomes after total knee arthroplasty: A Swedish registry‐based study of 7755 patients

Knee Surgery, Sports Traumatology, Arthroscopy, EarlyView.
Abstract Purpose Patients who have undergone anterior cruciate ligament reconstruction (ACLR) may later require total knee arthroplasty (TKA) due to osteoarthritis (OA). The impact of previous ACLR on patient‐reported outcomes (PROs) after TKA remains uncertain.
Ioannis Syrikas, Ioannis Karikis, Neel Desai, Georgios Tsikandylakis   +3 more
wiley   +1 more source

Indirect Striatal Projection Neurons Drive a D2 Receptor‐Dependent Pathway to Dyskinesia and Dystonia

Movement Disorders, EarlyView.
D2 receptor ablation in indirect‐pathway striatal neurons reduces or abolishes dyskinetic and dystonic behaviors induced by L‐DOPA or D2 receptor agonists, respectively. Contralateral turning is reduced, while forward locomotion is increased. These effects are associated with modulation of neuronal activity in dorsal striatum and external globus ...
Laura Andreoli, Teodor Nyman, Elena Espa, Johan Jakobsson, Osama F. Elabi, Maria Angela Cenci   +5 more
wiley   +1 more source

Physical activity and exercise participation—Impact on motor and non‐motor outcomes in early‐stage Parkinson disease: A cross‐sectional study

PM&R, EarlyView.
Abstract Background Aerobic exercise is beneficial in managing Parkinson disease (PD), yet its potential remains less clear in early stages. This study investigates the impact of long‐term aerobic exercise habits in individuals with early‐stage PD compared with healthy controls. Design Cross‐sectional study.
Cecilie Thrue, Frederik Bonde‐Jensen, Lars G. Hvid, Ulrik Dalgas, Martin Langeskov‐Christensen   +4 more
wiley   +1 more source

Ti3C2Tx (MXene)‐Polystyrene Based Passivation for Perovskite Solar Cells With Enhanced Stability

Small, EarlyView.
A new class of surface passivation strategy by integrating conductive 2D Ti3C2Tx and hydrophobic polystyrene for stable perovskite solar cells is introduced in this work. Polystyrene‐MXene passivated devices retained more than 93% of their initial efficiencies after storing in ambient air with high humidity conditions for 30 days.
Selengesuren Suragtkhuu, Purevlkham Myagmarsereejid, Isaac Etchells, Paul E. Shaw, Yu Lin Zhong, Munkhbayar Batmunkh   +5 more
wiley   +1 more source

Psilocybin‐assisted psychotherapy for methamphetamine use disorder: A pilot open‐label safety and feasibility study

Addiction, EarlyView.
Abstract Background & Aims There are few effective treatments for methamphetamine use disorder, despite increasing global demand. Here, we assessed the safety and feasibility of outpatient psilocybin‐assisted psychotherapy for methamphetamine use disorder. Design Single arm, open label pilot study.
Elizabeth Knock, Krista J. Siefried, Gill Bedi, Steven Albert, Richard O. Day, Nadine Ezard, Margaret Ross, Paul Liknaitzky, Jonathan Brett   +8 more
wiley   +1 more source