Results 131 to 140 of about 18,864 (234)

Progress in Strain Engineering of 2D‐Integrated Heterostructures for Ultrasensitive Sensors

Advanced Science, EarlyView.
 . ABSTRACT Two‐dimensional (2D) integrated heterostructures have emerged as a cornerstone in the advancement of next‐generation sensor technologies. These heterostructures, which combine materials with different dimensionalities, have led to significant breakthroughs in sensing performance and device integration.
That Buu Ton, Tuan Sang Tran, Duc Khanh Tran, Van Thanh Dau, Dzung Viet Dao   +4 more
wiley   +1 more source

Establishing the relationship of inhaler satisfaction, treatment adherence, and patient outcomes : A prospective, real-world, cross-sectional survey of US adult asthma patients and physicians [PDF]

, 2015
Date of Acceptance: 26/06/2015 Acknowledgements The disease-specific program, on which the analyses were based, was designed and run by Adelphi Real World. The program was supported by a number of pharmaceutical companies, including Meda Pharmaceuticals.
Harrow, Brooke, Higgins, Victoria, Pike, James, Price, David, Small, Mark   +4 more
core   +1 more source

Rewiring NADH Metabolism Through NQO1‐Mediated Redox Cycling for Targeted Follicular Lymphoma Therapy

Advanced Science, EarlyView.
ABSTRACT Follicular lymphoma (FL) remains an incurable B‐cell malignancy with high relapse rates, and conventional therapies are often limited by significant toxicity, highlighting the need for novel treatments. We identified that FL exhibits markedly low expression of NAD(P)H: quinone oxidoreductase 1 (NQO1), a key enzyme required for activating ...
Jinxing Zhang, Ziqi Wang, Ye Weng, Yulin Fu, Yuelong Jiang, Beilin Zhuang, Wenzi Zeng, Xiangchun Zhang, Bing Xu, Jie Zha, Hongjun Zhuang   +10 more
wiley   +1 more source

An occupational therapy intervention for residents with stroke related disabilities in UK care homes (OTCH): cluster randomised controlled trial [PDF]

, 2015
Objective To evaluate the clinical efficacy of an established programme of occupational therapy in maintaining functional activity and reducing further health risks from inactivity in care home residents living with stroke sequelae.
Barton, Garry, Burton, C. R., Burton, Christopher R., Fletcher-Smith, J., Fletcher-Smith, Joanna, Irvine, L., Irvine, Lisa, Lett, K., Mant, J., Mant, Jonathan, Masterson-Algar, Patricia, Peryer, G., Peryer, Guy, Rashid, Farzana, Roalfe, A. K., Roalfe, Andrea K., Sackley, Catherine M., Sharp, L., Sharp, Leslie, Sheehan, B., Sheehan, Bart, Stant, K. E., Stant, Katie E., Steel, Kerry, Steele, K., Walker, M. F., Walker, Marion F., Watkins, C. L., Watkins, Caroline L., Wheatley, K., Wheatley, Keith, Wilde, K., Wilde, Kate, Williams, Jane   +33 more
core   +5 more sources

PIEZO1 is Required for Acute Myeloid Leukemia Progression and Leukemia Stem Cell Maintenance via HIF1A‐SLC7A11 Axis‐Mediated Ferroptosis Defense

Advanced Science, EarlyView.
This study identifies the mechanosensor PIEZO1 as a key factor in promoting acute myeloid leukemia progression and uncovers a ferroptosis defense system mediated by PIEZO1‐HIF1A‐SLC7A11 axis that is essential for leukemia stem cell maintenance. This ferroptotic defense system may represent a unique vulnerability for leukemia stem cells, providing a ...
Tiantian Zhang, Ziyan Cao, Kexin Gao, Shuxin Yao, Yanbing Zheng, Manman Cui, Rong Yin, Guoqiang Han, Jin Hu, Chengyi Wang, Haojian Zhang   +10 more
wiley   +1 more source

Postural stability in older adults with a distal radial fracture [PDF]

, 2016
BACKGROUND: The physical risk factors leading to distal radial fractures are poorly understood. The goal of this study was to compare postural stability between older adults with and without a prior distal radial fragility fracture.
Allum, Andre K. Guthrie, Benson, Bliuc, Broglio, Charnock, Cho, Chung, Craig R. Louer, Cuddihy, Cummings, de Groot, Gillespie, Graafmans, Greig, John R. Motley, Kelsey, Khazzani, Komatsu, Larkin, Lindley B. Wall, Maki, Mallmin, Mallmin, Nguyen, Nordvall, Norman, O’Neill, Rozental, Rozental, Ryan P. Calfee, Sean L. Boone, Silman, Sinaki, Stevens, Tinetti, Washburn, Wilson, Wolf, Ziere   +39 more
core   +2 more sources

Neuromorphic Near‐Sensor and In‐Sensor Computing Enabled by Next‐Generation Material‐Based Sensors

Advanced Science, EarlyView.
This Review presents a structural framework that classifies neuromorphic sensing into near‐sensor and in‐sensor architectures, clarifying physical coupling between sensing and computation. The framework connects neural and synaptic device functions with recent advances in optical, mechanical, and chemical sensing, compares energy consumption and ...
Su Yeon Jung, Gwang Ya Kim, Sejin Kim, Hyunjong Seo, Se Gi Lee, Sang Min Won, Dongjoon Rhee, Joohoon Kang   +7 more
wiley   +1 more source

ID151 Avaliação da inequidade em saúde no Brasil: O instrumento EQ-5D-3L é capaz de detectar diferenças na qualidade de vida entre diferentes grupos socioeconômicos?

Jornal de Assistência Farmacêutica e Farmacoeconomia
Introdução Os instrumentos genéricos para mensuração da qualidade de vida relacionada à saúde são cada vez mais utilizados para avaliação da inequidade.
Milene Rangel da Costa, Bernardo Rangel Tura, Sylvia Lordello, Danillo Barros, Yuri Souza, Marisa da Silva Santos   +5 more
doaj   +1 more source

Aerobic and strength training exercise programme for cognitive impairment in people with mild to moderate dementia : the DAPA RCT [PDF]

, 2018
Background Approximately 670,000 people in the UK have dementia. Previous literature suggests that physical exercise could slow dementia symptom progression.
Alleyne, Sharisse, Atherton, Nicky, Brown, Deborah, Copsey, Bethan, Dosanjh, Sukhdeep, Finnegan, Susanne, Fordham, Beth, Griffiths, Frances, Hennings, Susie, Khan, Iftekhar, Khan, Kamran, Lall, Ranjit, Lamb, S. E. (Sallie E.), Lyle, Samantha A., Mistry, Dipesh, Nichols, Vivien P., Petrou, Stavros, Sheehan, Bart, Zeh, Peter   +18 more
core   +2 more sources

Aptamer‐Targeted PrPC Drives Colorectal Cancer Metastasis via a LYN‐STAT3 Complex and Enables Liquid Biopsy Detection

Advanced Science, EarlyView.
The aptamer WHY‐3E identifies PrPC as a CRC driver. Stabilized by USP18, endocytosed PrPC forms a LYN/STAT3 complex, upregulating MSN transcription to promote metastasis. Crucially, WHY‐3E sensitively detects PrPC‐positive circulating exosomes, establishing a robust theoretical foundation for non‐invasive clinical diagnostics.
Chunlin Wang, Hongyu Wu, Chaojing Zheng, Hao Zhang, Xiaoqiu Wu, Jiaqi Wang, Zewen Chang, Jun Xiang, Yunxiao Liu, Chenkai Zhang, Yuliuming Wang, Hao Jiang, Yuchen Zhong, Jun Luo, Ying Chen, NaNa Zhang, Weiyuan Zhang, Ziming Yuan, ChaoXia Zou, Weihong Tan, Meng Wang, Hanqing Hu, Tao Bing, Guiyu Wang   +23 more
wiley   +1 more source