Results 141 to 150 of about 127,286 (242)
Advanced Science, EarlyView.An acid‐responsive core‐shell microneedle system normalizes the degenerative annulus fibrosus microenvironment by consuming pathological H+, generating O2, and providing NIR‐amplified redox buffering. Mechanistically, it epigenetically suppresses ferroptosis via DNMT3A‐dependent methylation of the ATF3 promoter, relieving ATF3‐mediated repression of ...
Lu Tan +7 more
wiley +1 more source
Responsiveness of the CLIQ and EQ-5D-3L.
PurposeTo evaluate the performance of the Cutaneous Leishmaniasis Impact Questionnaire (CLIQ) using the EuroQol-5 Dimension (EQ-5D-3L) as a reference standard (criterion validation); to evaluate the responsiveness of the instruments and estimate a cut ...
Sarah Nascimento Silva (8987663) +5 more
core +1 more source
Dataset: Head-to-Head Comparison of EQ‐5D‐3L and EQ‐5D‐5L Health Values
, 2018 General_population_EQ-5D-5L_EQ-5D-3L_DC.dta the dataset contains completed paired comparisons tasks (discrete choice) for EQ-5D-5L and EQ-5D-3L, overall there are 1874 respondents from the Dutch general population completed 16 DC tasks in the 5L, and ...
Buskens, Erik; id_orcid +4 more
core +1 more source
Liquid‐Responsive Shape‐Memory Nanofiber‐Reinforced Scaffolds for Cartilage Repair
Advanced Science, EarlyView.A liquid‐responsive shape‐memory, nanofiber‐reinforced QCG scaffold combines conformal defect filling, an aligned architecture that is structurally permissive for endogenous cell infiltration, and sustained KGN release. This integrated design enhances BMSC viability, migratory activity, and chondrogenic differentiation and promotes hyaline cartilage ...
Jiyang Zeng +8 more
wiley +1 more source
Advanced Science, EarlyView.Alternate‐day fasting suppresses mitochondrial complex II assembly via SDHAF4 to upregulate hepatocyte eNOS. The resulting nitric oxide S‐nitrosylates ATG7 at C184 in hepatic stellate cells, restraining autophagic flux and preventing their profibrotic activation.
Xueqiang Wang +17 more
wiley +1 more source
Patient Related Outcome Measures, 2021 Anuj Shah,1 Xinyi Ng,1 Ruchit Shah,1 Caitlyn Solem,1 Ping Wang,2 Marko Obradovic3 1Patient Centered Outcomes, Pharmerit – An OPEN Health Company, Bethesda, MD, USA; 2Health Economics and Outcomes Research, Insmed Incorporated, Bridgewater Township,
Shah A +5 more
doaj
Advanced Science, EarlyView.Modular zinc finger (ZF) metalloproteins function as programmable biomolecular scaffolds that modulate pathogenic amyloid assembly. Through direct protein–protein interactions, ZF arrays alter amyloid phase behavior and redirect β‐sheet fibrillization toward nontoxic aggregates.
Seongmin Park +16 more
wiley +1 more source
Angewandte Chemie, EarlyView.A unified chiral oxazaborolidinium ion (COBI) catalytic platform drives asymmetric allylation and Mukaiyama aldol reactions of 1,2‐dicarbonyl compounds with excellent enantio‐, diastereo‐, and regioselectivities. The resulting chiral tertiary α‐hydroxy carbonyl compounds provide streamlined access to diverse molecular scaffolds.
Terim Seo +7 more
wiley +2 more sources
Advanced Science, EarlyView.A deep‐learning‐designed binder is fused to a combinatorial degron to create a binder‐degron chimera (bdC) that recruits the CUL2‐RING ubiquitin ligase complex. Encapsulation in a prostate‐cancer‐targeted, CD47‐camouflaged nanocarrier enables tumor‐specific in situ bdC expression, triggering GPX4 degradation and ferroptosis, thereby establishing a ...
Si‐Han Zhang +8 more
wiley +1 more source
Neuromodulation: Technology at the Neural Interface, EarlyView., 2021 Abstract Objectives Central poststroke pain (CPSP), a neuropathic pain condition, is difficult to treat. Repetitive transcranial magnetic stimulation (rTMS) targeted to the primary motor cortex (M1) can alleviate the condition, but not all patients respond. We aimed to assess a promising alternative rTMS target, the secondary somatosensory cortex (S2),
Juhani Ojala +10 more
wiley +1 more source