Results 41 to 50 of about 76,926 (244)

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Stakeholders’ perspectives on implementing and integrating patient-reported outcome measures (PROMs) in health systems - insights from Alberta, Canada

Journal of Patient-Reported Outcomes
Background Patient-reported outcome measures (PROMs) are valuable tools for evaluating outcomes of healthcare interventions and have been increasingly used in health systems around the world.
Fatima Al Sayah, Hilary Short, Arto Ohinmaa, Stafford Dean, Brenda Hubley, Markus Lahtinen, Jeffrey A. Johnson   +6 more
doaj   +1 more source

Exploring the relation between the EQ-5D-5L pain/discomfort and pain and itching in a sample of burn patients

Health and Quality of Life Outcomes, 2020
Background The EQ-5D domain pain/discomfort (PD) uses one item to capture pain and other aspects of discomfort, like itching. This study explored how pain, itching and the EQ-5D-5L PD domain relate to each other in a sample of burn patients.
I. Spronk, G. J. Bonsel, S. Polinder, M. E. van Baar, M. F. Janssen, J. A. Haagsma   +5 more
doaj   +1 more source

A pilot study on the validity and psychometric properties of the electronic EQ-5D-5L in routine clinical practice

Health and Quality of Life Outcomes, 2021
Background Electronic measurement of health-related quality of life (HRQOL) may facilitate timely and regular assessments in routine clinical practice. This study evaluated the validity and psychometric properties of an electronic version of the EQ-5D-5L
Cindy Lo Kuen Lam, Emily Tsui Yee Tse, Carlos King Ho Wong, Joyce Sau Mei Lam, Sikky Shiqi Chen, Laura Elizabeth Bedford, Jason Pui Yin Cheung, Calvin Kalun Or, Paul Kind   +8 more
doaj   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Using Patient‐Reported Outcomes in Two Program Examples Measuring Health Status in Primary Care: An Observational Study

Health Science Reports
Background and Aims Patient‐reported outcome measures (PROMs) are increasingly used in primary care practices; however, the broad characteristics of this population pose unique challenges. Generic PROMs (e.g., EQ‐5D‐5L) measure general health status from
Allison L. Soprovich, Hilary Short, Al‐Bakir Ali, Krista Brower, Arto Ohinmaa, Jeffrey A. Johnson   +5 more
doaj   +1 more source

Validity and responsiveness of the EQ-5D in assessing and valuing health status in patients with somatoform disorders

Health and Quality of Life Outcomes, 2013
Background The EQ-5D is a generic questionnaire providing a preference-based index score applicable to cost-utility analysis. This is the first study to validate the EQ-5D in patients with somatoform disorders.
Brettschneider Christian, König Hans-Helmut, Herzog Wolfgang, Kaufmann Claudia, Schaefert Rainer, Konnopka Alexander   +5 more
doaj   +1 more source

Quantitative proteomic analysis reveals different characteristics of bladder cancer cells after exposure to bisphenol A

FEBS Open Bio, EarlyView.
Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu, Lanlan Li, Wenjuan Jia, Hanzhong Feng, Xiaoquan Yu, Youli Zhao, Fengzhi Yuan, Hui Ding, Junqiang Tian, Yong‐Xing He, Zhiping Wang   +10 more
wiley   +1 more source

Validation of the EQ-5D in Taiwan using item response theory

BMC Public Health, 2021
Background Our study aims to provide validity evidence for the EuroQol five dimensions questionnaire (EQ-5D) in the National Health Interview Survey of Taiwan in the 2013 wave and further interpret the EQ-5D scores for patients with chronic diseases ...
Tzu-Hung Liu, Andrew D. Ho, Yu-Tien Hsu, Chih-Cheng Hsu   +3 more
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source