Results 51 to 60 of about 129,955 (287)

Patients as partners in a research advisory council role: describing the APERSU Patient Engagement Network

Journal of Patient-Reported Outcomes
Patient and public involvement and engagement (PPIE) is crucial for developing patient-centered healthcare research and improving health outcomes. While patient-reported outcome measures (PROMs) capture patients’ perspectives, meaningfully engaging ...
Sadia Ahmed, Marcia Bruce, D’Arcy Duquette, Veronika Kiryanova, Meron Seyoum, Simron Sidhu, Gloria Wilkinson, Fatima Al Sayah, Jeffrey A. Johnson, Arto Ohinmaa, Allison Soprovich   +10 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

A pilot study on the validity and psychometric properties of the electronic EQ-5D-5L in routine clinical practice

Health and Quality of Life Outcomes, 2021
Background Electronic measurement of health-related quality of life (HRQOL) may facilitate timely and regular assessments in routine clinical practice. This study evaluated the validity and psychometric properties of an electronic version of the EQ-5D-5L
Cindy Lo Kuen Lam, Emily Tsui Yee Tse, Carlos King Ho Wong, Joyce Sau Mei Lam, Sikky Shiqi Chen, Laura Elizabeth Bedford, Jason Pui Yin Cheung, Calvin Kalun Or, Paul Kind   +8 more
doaj   +1 more source

Quality of life and well-being of carers of people with dementia: are there differences between working and nonworking carers? Results from the IDEAL program [PDF]

, 2020
The aim of this study was to identify the differences in quality of life (QoL) and well-being between working and nonworking dementia carers and the relative contribution of psychological characteristics, caregiving experience, and social support ...
Bech P., Doewick A., Dugan A. G., Healthways, Hillage J., Johannessen A., Masselot A., Newbronner L., NurFatihah O. A., Rattinger G. B., Schwarzer R.   +10 more
core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

An analysis of the complementarity of ICECAP-A and EQ-5D-3L in an adult population of patients with knee pain [PDF]

, 2016
BACKGROUND: The ICECAP measures potentially offer a broader assessment of quality of life and well-being, in comparison to measures routinely used in economic evaluation, such as the EQ-5D-3 L.
Al-Janabi, Hareth, Coast, Joanna, Foster, Nadine E., Jowett, Susan, Keeley, Thomas, Nicholls, Elaine   +5 more
core   +5 more sources

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Using Patient‐Reported Outcomes in Two Program Examples Measuring Health Status in Primary Care: An Observational Study

Health Science Reports
Background and Aims Patient‐reported outcome measures (PROMs) are increasingly used in primary care practices; however, the broad characteristics of this population pose unique challenges. Generic PROMs (e.g., EQ‐5D‐5L) measure general health status from
Allison L. Soprovich, Hilary Short, Al‐Bakir Ali, Krista Brower, Arto Ohinmaa, Jeffrey A. Johnson   +5 more
doaj   +1 more source

Exploring the relation between the EQ-5D-5L pain/discomfort and pain and itching in a sample of burn patients

Health and Quality of Life Outcomes, 2020
Background The EQ-5D domain pain/discomfort (PD) uses one item to capture pain and other aspects of discomfort, like itching. This study explored how pain, itching and the EQ-5D-5L PD domain relate to each other in a sample of burn patients.
I. Spronk, G. J. Bonsel, S. Polinder, M. E. van Baar, M. F. Janssen, J. A. Haagsma   +5 more
doaj   +1 more source

Modelling the relationship between the WOMAC osteoarthritis index and EQ-5D [PDF]

, 2014
Objective Economic evaluation typically is conducted using health state utilities to estimate treatment benefits. However, such outcomes are often missing from studies of clinical effectiveness.
Alava, M. H., Escobar Martinez, A., Wailoo, A.   +2 more
core   +1 more source