Results 61 to 70 of about 129,955 (287)

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Stakeholders’ perspectives on implementing and integrating patient-reported outcome measures (PROMs) in health systems - insights from Alberta, Canada

Journal of Patient-Reported Outcomes
Background Patient-reported outcome measures (PROMs) are valuable tools for evaluating outcomes of healthcare interventions and have been increasingly used in health systems around the world.
Fatima Al Sayah, Hilary Short, Arto Ohinmaa, Stafford Dean, Brenda Hubley, Markus Lahtinen, Jeffrey A. Johnson   +6 more
doaj   +1 more source

An assessment of validity and responsiveness of generic measures of health-related quality of life in hearing impairment [PDF]

, 2013
This article is made available through the Brunel Open Access Publishing Fund. This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the ...
A Vuorialho, A Vuorialho, AK Cheng, AS Pickard, BG Bichey, CA Marra, CS Palmer, D Feeny, D Feeny, D Papaioannou, DL Streiner, DS Dalton, G Hawthorne, G Kobelt, GR Barton, GR Barton, GW Torrance, GWJA Damen, HY Lee, J Brazier, J Brazier, J Brazier, JE Brazier, JE Brazier, John Brazier, JPC Grutters, L Longworth, L Smith-Olinde, Louise Longworth, M Joore, MA Joore, MA Joore, MAB Joore, MKS Hol, P Dolan, PFM Krabbe, PK Sand, R Brooks, R Harper, RES Lovett, TH Sach, Y Yang, Yaling Yang   +42 more
core   +3 more sources

Quantitative proteomic analysis reveals different characteristics of bladder cancer cells after exposure to bisphenol A

FEBS Open Bio, EarlyView.
Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu, Lanlan Li, Wenjuan Jia, Hanzhong Feng, Xiaoquan Yu, Youli Zhao, Fengzhi Yuan, Hui Ding, Junqiang Tian, Yong‐Xing He, Zhiping Wang   +10 more
wiley   +1 more source

Validation of the EQ-5D in Taiwan using item response theory

BMC Public Health, 2021
Background Our study aims to provide validity evidence for the EuroQol five dimensions questionnaire (EQ-5D) in the National Health Interview Survey of Taiwan in the 2013 wave and further interpret the EQ-5D scores for patients with chronic diseases ...
Tzu-Hung Liu, Andrew D. Ho, Yu-Tien Hsu, Chih-Cheng Hsu   +3 more
doaj   +1 more source

EQ-5D-3L Derived Population Norms for Health Related Quality of Life in Sri Lanka [PDF]

, 2014
Background Health Related Quality of Life (HRQoL) is an important outcome measure in health economic evaluation that guides health resource allocations.
CK Ranawaka, E Abdin, H Jayasekara, HG Koenig, HH Konig, J Gundgaard, J Sorensen, Jennifer A. Whitty, Karin Bammann, L Ekanayake, N Luo, Newell W. Johnson, P Kind, P Kind, Paul A. Scuffham, R Norman, Ruwan Jayasinghe, S Clemens, S Kularatna, S Sun, Sanjeewa Kularatna, SD Nanayakkara, T Tasiemski, TGAN Chandrasena   +23 more
core   +3 more sources

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Comparing responsiveness of the EQ-5D-5L, EQ-5D-3L and EQ VAS in stroke patients [PDF]

, 2015
Aims: To date, evidence to support the construct validity of the EQ-5D-5L has primarily focused on cross-sectional data. The aims of this study were to examine the responsiveness of EQ-5D-5L in patients with stroke and to compare it with responsiveness ...
Buczek, J. (Julia), Golicki, D. (Dominik), Janssen, M.F. (Bas), Karlińska, A. (Anna), Kobayashi, A. (Adam), Niewada, M. (Maciej), Pickard, A.S. (Simon)   +6 more
core   +3 more sources

Value of MRI Outcomes for Preventive and Early‐Stage Trials in Spinocerebellar Ataxias 1 and 3

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To examine the value of MRI outcomes as endpoints for preventive and early‐stage trials of two polyglutamine spinocerebellar ataxias (SCAs). Methods A cohort of 100 participants (23 SCA1, 63 SCA3, median Scale for the Assessment and Rating of Ataxia (SARA) score = 5, 42% preataxic, and 14 gene‐negative controls) was scanned at 3T up ...
Thiago J. R. Rezende, Emilien Petit, Young Woo Park, Sophie Tezenas du Montcel, James M. Joers, Jonathan M. DuBois, H. Moore Arnold, Michal Povazan, Ipek Özdemir, Guita Banan, Romain Valabregue, Philipp Ehses, Jennifer Faber, Chiadi U. Onyike, Peter B. Barker, Jeremy D. Schmahmann, Eva‐Maria Ratai, Sub H. Subramony, Thomas H. Mareci, Khalaf O. Bushara, Henry Paulson, Thomas Klockgether, Alexandra Durr, Tetsuo Ashizawa, Christophe Lenglet, Gülin Öz, READISCA Investigators   +26 more
wiley   +1 more source

Use of patient-reported outcome measures (PROMs) in primary care-based mental health programming: an environmental scan of Alberta, Canada

BMC Primary Care
Background Many Primary Care Networks (PCNs) in Alberta collect Patient Reported Outcome Measures (PROMs) to support patient-centered care. However, there is limited knowledge on what tools are currently being administered across PCNs and how the data is
Oacia Fair, Al-Bakir Ali, Michel Haener, Kara Plotnikoff, Nolan Schaaf, Margo Schmitt-Boshnick, Allison Soprovich   +6 more
doaj   +1 more source