Results 71 to 80 of about 128,279 (290)

Experience-based VAS values for EQ-5D-3L health states in a national general population health survey in China [PDF]

, 2014
Purpose: To investigate the feasibility of deriving experience-based visual analogue scale (VAS) values for EQ-5D-3L health states using national general population health survey data in China.
A Gandjour, A Szende, B Leung, C Gutenbrunner, C Naylor, D Parkin, D Polsky, EA Stolk, F Xie, FA Md Yusof, FL Zhao, GA Wit De, H Wang, I Cleemput, J Brazier, J Tobin, Jiaying Chen, JM Hilbe, JW Shaw, JW Shaw, K Burström, K Burström, K Rand-Hendriksen, Kristina Burström, Ling Xu, MF Drummond, N Luo, N Zethraeus, P Dolan, P Dolan, P Dolan, P Dolan, PA Ubel, Paul Kind, R Leidl, R Mann, R Rabin, S Sun, S Sun, SAS Institute Inc, Sun Sun, W Greiner, W Greiner, X Badia, Yaoguang Zhang   +44 more
core   +2 more sources

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Use of patient-reported outcome measures (PROMs) in primary care-based mental health programming: an environmental scan of Alberta, Canada

BMC Primary Care
Background Many Primary Care Networks (PCNs) in Alberta collect Patient Reported Outcome Measures (PROMs) to support patient-centered care. However, there is limited knowledge on what tools are currently being administered across PCNs and how the data is
Oacia Fair, Al-Bakir Ali, Michel Haener, Kara Plotnikoff, Nolan Schaaf, Margo Schmitt-Boshnick, Allison Soprovich   +6 more
doaj   +1 more source

Health-related quality of life and Chlamydia trachomatis infection in sexually experienced female inner-city students: a community-based cross-sectional study. [PDF]

, 2016
This cross-sectional study was undertaken to compare health-related quality of life (EQ-5D) in women with and without undiagnosed Chlamydia trachomatis infection.
Kerry, SR, Nightingale, C, Oakeshott, P, Southgate, E, Sri, T   +4 more
core   +2 more sources

EQ-5D-5L Value Set for Slovenia

PharmacoEconomics, 2023
The aim of this valuation study was to produce a value set to support the use of EQ-5D-5L data in decision making in Slovenia.The study design followed the published EuroQol research protocol, and a quota sample was defined according to age, sex, and region.
Valentina Prevolnik Rupel, Marko Ogorevc
openaire   +2 more sources

Cutaneous Phosphorylated Alpha‐Synuclein in Lewy Body Dementia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To determine the test performance of cutaneous phosphorylated alpha‐synuclein (P‐SYN) in dementia with Lewy bodies (DLB), individuals with reduced Montreal Cognitive Assessment (MoCA) and healthy controls. Methods This is the first subgroup analysis of the Synuclein‐One study, a prospective, blinded study evaluating P‐SYN detection ...
Christopher H. Gibbons, Todd Levine, Charles H. Adler, Bailey Bellaire, Ningshan Wang, Pinky Agarwal, Georgina M. Aldridge, Alexandru Barboi, Daniel Claassen, Virgilio G. H. Evidente, Douglas Galasko, Alejandra Gonzalez‐Duarte, Ramon Gil, Mark Gudesblatt, Stuart H. Isaacson, Horacio Kaufmann, Pravin Khemani, Rajeev Kumar, Guillaume Lamotte, Andy J. Liu, Nikolaus R. McFarland, Mitchell G. Miglis, Adam Reynolds, Gregory A. Sahagian, Marie‐Helene Saint‐Hilaire, Julie B. Schwartzbard, Wolfgang Singer, Michael J. Soileau, Steven Vernino, Patricio Millar Vernetti, Oleg Yerstein, Roy Freeman   +31 more
wiley   +1 more source

An assessment of validity and responsiveness of generic measures of health-related quality of life in hearing impairment [PDF]

, 2013
This article is made available through the Brunel Open Access Publishing Fund. This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the ...
A Vuorialho, A Vuorialho, AK Cheng, AS Pickard, BG Bichey, CA Marra, CS Palmer, D Feeny, D Feeny, D Papaioannou, DL Streiner, DS Dalton, G Hawthorne, G Kobelt, GR Barton, GR Barton, GW Torrance, GWJA Damen, HY Lee, J Brazier, J Brazier, J Brazier, JE Brazier, JE Brazier, John Brazier, JPC Grutters, L Longworth, L Smith-Olinde, Louise Longworth, M Joore, MA Joore, MA Joore, MAB Joore, MKS Hol, P Dolan, PFM Krabbe, PK Sand, R Brooks, R Harper, RES Lovett, TH Sach, Y Yang, Yaling Yang   +42 more
core   +3 more sources

Value of MRI Outcomes for Preventive and Early‐Stage Trials in Spinocerebellar Ataxias 1 and 3

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To examine the value of MRI outcomes as endpoints for preventive and early‐stage trials of two polyglutamine spinocerebellar ataxias (SCAs). Methods A cohort of 100 participants (23 SCA1, 63 SCA3, median Scale for the Assessment and Rating of Ataxia (SARA) score = 5, 42% preataxic, and 14 gene‐negative controls) was scanned at 3T up ...
Thiago J. R. Rezende, Emilien Petit, Young Woo Park, Sophie Tezenas du Montcel, James M. Joers, Jonathan M. DuBois, H. Moore Arnold, Michal Povazan, Ipek Özdemir, Guita Banan, Romain Valabregue, Philipp Ehses, Jennifer Faber, Chiadi U. Onyike, Peter B. Barker, Jeremy D. Schmahmann, Eva‐Maria Ratai, Sub H. Subramony, Thomas H. Mareci, Khalaf O. Bushara, Henry Paulson, Thomas Klockgether, Alexandra Durr, Tetsuo Ashizawa, Christophe Lenglet, Gülin Öz, READISCA Investigators   +26 more
wiley   +1 more source

EQ-5D-5L versus EQ-5D-3L: The Impact on Cost Effectiveness in the United Kingdom [PDF]

Value in Health, 2018
To model the relationship between the three-level (3L) and the five-level (5L) EuroQol five-dimensional questionnaire and examine how differences have an impact on cost effectiveness in case studies.We used two data sets that included the 3L and 5L versions from the same respondents.
Hernandez Alava, M., Wailoo, A., Grimm, S., Pudney, S., Gomes, M., Sadique, Z., Meads, D., O'Dwyer, J., Barton, G., Irvine, L.   +9 more
openaire   +7 more sources

Epilepsy‐Associated Variants of a Single SCN1A Codon Exhibit Divergent Functional Properties

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Pathogenic variants in SCN1A, which encodes the voltage‐gated sodium channel NaV1.1, are associated with multiple epilepsy syndromes exhibiting a range of clinical severity. SCN1A variants are reported in different syndromes, including Dravet syndrome, which is associated with loss‐of‐function, whereas neonatal/infantile‐onset ...
Lanie N. Liebovitz, Christopher H. Thompson, Linda C. Laux, Alfred L. George Jr.   +3 more
wiley   +1 more source