Results 101 to 110 of about 41,400 (238)

Mining Potential Therapeutic Targets for T Cell Exhaustion in Osteoarthritis by Integrating Mendelian Randomization and Single‐Cell Sequencing

The FASEB Journal, Volume 40, Issue 2, 31 January 2026.
This study conducted an integrated analysis using multi‐source data, with specific data sources including the GEO database (encompassing datasets GSE55235, GSE55457, and GSE152805), literature‐mined gene sets, and the IEU OpenGWAS database (dataset ebi‐a‐GCST005814).
Jiahong Li, Yi Ye, Yan Zhang, Wei Fang, Fei Lan, Qian Yang, Lun Wan, Jiang Hu, Chengwei Xiao, Kun Zhang   +9 more
wiley   +1 more source

A framework for integrating directed and undirected annotations to build explanatory models of cis-eQTL data.

PLoS Computational Biology, 2020
A longstanding goal of regulatory genetics is to understand how variants in genome sequences lead to changes in gene expression. Here we present a method named Bayesian Annotation Guided eQTL Analysis (BAGEA), a variational Bayes framework to model cis ...
David Lamparter, Rajat Bhatnagar, Katja Hebestreit, T Grant Belgard, Alice Zhang, Victor Hanson-Smith   +5 more
doaj   +1 more source

Cell-type-specific cis-eQTLs in eight human brain cell types identify novel risk genes for psychiatric and neurological disorders

, 2022
Julien Bryois, Daniela Calini, Will Macnair, Lynette C. Foo, Eduard Urich, Ward Ortmann, Victor A. Iglesias, Suresh Selvaraj, Erik Nutma, Manuel Marzin, Sandra Amor, Anna Williams, Gonçalo Castelo‐Branco, Vilas Menon, Philip L. De Jager, Dheeraj Malhotra   +15 more
openalex   +2 more sources

Single‐Cell Genetic Mapping of Gasdermin Expression Across Immune‐Mediated Inflammatory Diseases

The FASEB Journal, Volume 40, Issue 1, 15 January 2026.
This figure illustrates the lineage‐specific causal effects of gasdermin (GSDM) expression on the risk of eight immune‐mediated inflammatory diseases (IMIDs). The analysis, based on single‐cell genetic data, shows how GSDMA, GSDMB, and GSDMD affect disease risk in various immune cell types, highlighting distinct protective or risk‐enhancing roles in ...
Xin Gao, Xiaofeng Guo, Kaige Yin, Xiaoxu Jin   +3 more
wiley   +1 more source

A Pan‐TE Map Reveals the Important Role of Transposable Elements in Gene Expression and Phenotypic Diversity in 2,311 Rapeseed Accessions

Advanced Science, Volume 13, Issue 4, 19 January 2026.
This study presents the first pan‐transposable element (TE) atlas in rapeseed, profiling over 8 million TEs across 2311 accessions. Integrative analyses reveal that TEs broadly shape gene expression through diverse regulatory mechanisms, with key insertions in BnaA03.FLC and BnaA09.CYP78A9 linked to flowering time and silique development.
Zhiquan Yang, Haiyan Fan, Yifan Chen, Jiawei Li, Minjian Chen, Yingying Tan, Liang Guo, Jintao Li, Kede Liu, Qing‐Yong Yang   +9 more
wiley   +1 more source

Dysregulated protocadherin-pathway activity as an intrinsic defect in induced pluripotent stem cell-derived cortical interneurons from subjects with schizophrenia. [PDF]

, 2019
We generated cortical interneurons (cINs) from induced pluripotent stem cells derived from 14 healthy controls and 14 subjects with schizophrenia. Both healthy control cINs and schizophrenia cINs were authentic, fired spontaneously, received functional ...
Apud, Jose, Berman, Karen F, Bin Kim, Woong, Cho, Jun-Hyeong, Chung, Sangmi, Cohen, Bruce M, Cote, Sarah E, Coyle, Joseph T, Eggan, Kevin C, Eisenberg, Leonard M, Fukuda, Emi, Ghosh, Sulagna, Hirayama, Teruyoshi, Huang, Weihua, Kim, Hae-Young, Lanz, Thomas A, McPhie, Donna L, Moghadam, Alexander A, Nguyen, Christine, Ni, Peiyan, Noh, Haneul, Noyes, Elizabeth, Ongur, Dost, Park, James M, Park, Joshua J, Parsons, Teagan, Perlis, Roy H, Rapoport, Judith L, Shao, Zhicheng, Stanton, Patric K, Straub, Richard E, Weinberger, Daniel R, Xi, Hualin Simon, Yagi, Takeshi, Yin, Changhong, Zhao, Joyce, Zheng, Kelvin   +36 more
core   +1 more source

Integrative Omics Defines Metabolic Biomarkers and Genetic Regulatory Mechanisms of Mortality Risk

Advanced Science, Volume 13, Issue 3, 14 January 2026.
Understanding mortality mechanisms remains a fundamental challenge. Through multi‐omics analysis of a three‐generation chicken model, are identified 45,585 mQTLs and establish a 16‐metabolite predictor of mortality. An inflammation‐growth trade‐off and evolutionarily conserved pathways involving butyrate–microbiota interactions and L‐cysteine's dual ...
Peihao Liu, Bingxing An, Jumei Zheng, Qiao Wang, Zhirui Yang, Zhengda Li, Dawei Liu, Fan Ying, Jie Wen, Lingzhao Fang, Guiping Zhao   +10 more
wiley   +1 more source

Genetic Association Between Polymyositis/Dermatomyositis and Epilepsy: Insights From Mendelian Randomization and Bioinformatic Analyses

Brain and Behavior, Volume 16, Issue 1, January 2026.
This Mendelian randomization study provides robust evidence for a causal link between polymyositis (PM) and epilepsy, highlighting the role of immune‐mediated mechanisms in epilepsy development, while no such association was found for dermatomyositis (DM). Through bioinformatic and statistical analyses, key genes and pathways were identified, with IER3,
Ying Liu, Yuhang Yu, Chulong Fang, Qingzhong Wu, Lingli Ou, Jianhao Xiao, Kui Duan, Ting Jiang, Lan Ye, Xiao Hu, Zhanhui Feng   +10 more
wiley   +1 more source

Unraveling Novel Genetic Determinants of Thiopurine Response Via TWAS

Clinical Pharmacology &Therapeutics, Volume 119, Issue 1, Page 84-88, January 2026.
Acute lymphoblastic leukemia (ALL) is the most common childhood cancer. Thiopurines such as 6‐mercaptopurine (6MP) are essential in ALL maintenance therapy. However, dose‐limiting toxicities can significantly disrupt treatment. While genetic variants in TPMT and NUDT15 are known to affect thiopurine response, many patients with normal function ...
Carlotta Bidoli, Wenjian Yang, Seth E. Karol, Marianna Lucafò, Gabriele Stocco, Jun J. Yang   +5 more
wiley   +1 more source

Integrative Evidence From Metabolome‐Wide Mendelian Randomization and Animal Models Implicates Tyrosine in Cardiac Hypercontractility and Arrhythmia Risk

Food Frontiers, Volume 7, Issue 1, January 2026.
Plasma metabolome‐wide Mendelian randomization analysis established a causal link between tyrosine and arrhythmia. GWAS meta‐analysis identified tyrosine‐associated loci linked to cardiovascular risk factors. Animal studies confirmed that oral tyrosine intake modulates heart rhythm via adrenergic signaling activation.
Zhikang Cao, Huiying Liu, Peng Chen, Liyue Chen, Zhixin Chen, Jiaqiang Lin, Zixuan Fu, Zhipeng Li   +7 more
wiley   +1 more source