Results 111 to 120 of about 48,393 (270)

Single cell eQTL analysis identifies cell type-specific genetic control of gene expression in fibroblasts and reprogrammed induced pluripotent stem cells

bioRxiv, 2020
Background The discovery that somatic cells can be reprogrammed to induced pluripotent stem cells (iPSCs) has provided a foundation for in vitro human disease modelling, drug development and population genetics studies.
Drew R. Neavin, Q. Nguyen, Maciej S Daniszewski, Helena H. Liang, H. Chiu, Y. K. Wee, A. Senabouth, S. Lukowski, Duncan E. Crombie, Grace E. Lidgerwood, Damián Hernández, J. Vickers, A. Cook, N. Palpant, A. Pébay, A. Hewitt, J. Powell   +16 more
semanticscholar   +1 more source

MendelR: A One‐Stop R Toolkit for Mendelian Randomization Analysis

Med Research, EarlyView.
ABSTRACT MendelR is a fully automated R package specifically developed for Mendelian randomization (MR) studies, designed to address the technical challenges of causal inference in biomedical research. As a powerful causal inference method, Mendelian randomization can effectively reduce confounding bias in observational studies.
Xiaohong Ke, Kailai Li, Anqi Lin, Yasi Zhang, Peng Luo   +4 more
wiley   +1 more source

Insight into genetic regulation of miRNA in mouse brain

BMC Genomics, 2019
Background micro RNA (miRNA) are important regulators of gene expression and may influence phenotypes and disease traits. The connection between genetics and miRNA expression can be determined through expression quantitative loci (eQTL) analysis, which ...
Gordon Kordas, Pratyaydipta Rudra, Audrey Hendricks, Laura Saba, Katerina Kechris   +4 more
doaj   +1 more source

Comprehensive Evidence for Mortality and Underlying Morbidity Related to Visceral Fat Distribution

Med Research, EarlyView.
ABSTRACT Linking obesity to mortality is an intriguing and controversial topic. This study tried to comprehensively assess 8 adiposity surrogates and mortality association among middle‐to‐old‐aged adults to identify a superior one, and explore explanatory disorders. Data sources included the National Health and Nutrition Examination Survey (NHANES), UK
Haolong Zhou, Danyang Ling, Qin Huang, Jiaojun Liang, Guanhua Su, Zhangbo Cui, Ziwei Chen, Xiaowen Ma, Zhou Jiang, Shuo Zheng, Haodong Tian, Qi Wang   +11 more
wiley   +1 more source

Comparison of quantitative trait loci methods: Total expression and allelic imbalance method in brain RNA-seq.

PLoS ONE, 2019
BackgroundOf the 108 Schizophrenia (SZ) risk-loci discovered through genome-wide association studies (GWAS), 96 are not altering the sequence of any protein. Evidence linking non-coding risk-SNPs and genes may be established using expression quantitative
Jesper R Gådin, Alfonso Buil, Carlo Colantuoni, Andrew E Jaffe, Jacob Nielsen, Joo-Heon Shin, Thomas M Hyde, Joel E Kleinman, BrainSeq Consortium, Niels Plath, Per Eriksson, Søren Brunak, Michael Didriksen, Daniel R Weinberger, Lasse Folkersen   +14 more
doaj   +1 more source

Mendelian randomization integrating GWAS and eQTL data revealed genes pleiotropically associated with major depressive disorder

Translational Psychiatry, 2020
Previous genome-wide association studies (GWAS) have identified potential genetic variants associated with the risk of major depressive disorder (MDD), but the underlying biological interpretation remains largely unknown.
Huarong Yang, Di Liu, Chuntao Zhao, Bowen Feng, Wenjin Lu, Xiaohan Yang, Minglu Xu, Wei Zhou, Huiquan Jing, Jingyun Yang   +9 more
semanticscholar   +1 more source

Identification of genetically predicted protein biomarkers and drug targets for prostate cancer via Mendelian randomization

VIEW, EarlyView.
Prostate cancer, a leading cause of cancer in men globally, urgently requires improved diagnostic and treatment strategies. This study analyzed large genetic datasets and identified five key proteins (THBD, DST, IFI27L2, OSBPL10, PPP1R14A) that either increase or decrease cancer risk, while also exploring their roles in immune response and potential ...
Maoping Cai, Tianming Peng, Zhiyue Xie, Chuqian Zhen, Chen Yao, Nan Peng, Qianyi Li, Yuzhong Yu, Jiming Bao, Xian‐Lu Song, Mingkun Chen, Shan‐Chao Zhao   +11 more
wiley   +1 more source

eQTLs in Glioblastoma Multiforme

, 2013
Like all cancers, Glioblastoma multiforme (GBM), the most common and deadly primary brain tumor, is an evolutionary disease: mutations in glial cell lineages change gene expression, leading to tumor growht and metastatic disease. How genomic changes influence gene expression is not well understood.
Lab, Claus Wilke, Shpak, Max, Hall, Amelia, Goldberg, Marcus, Derryberry, Dakota Z., Cowperthwaite, Matthew C.   +5 more
openaire   +1 more source

TreeQTL: hierarchical error control for eQTL findings [PDF]

Bioinformatics, 2015
Abstract Summary: Commonly used multiplicity adjustments fail to control the error rate for reported findings in many expression quantitative trait loci (eQTL) studies. TreeQTL implements a hierarchical multiple testing procedure which allows control of appropriate error rates defined relative to a grouping of the eQTL hypotheses.
Peterson, Christine, Bogomolov, Marina, Benjamini, Yoav, Sabatti, Chiara   +3 more
openaire   +3 more sources

(Re)-conciliation of genetics and genomics approaches for cotton fiber quality improvement [PDF]

, 2008
The integration of genomics and plant breeding is driven by the increasing availability of sequence resources and by technological developments. The simultaneous measurement of the expression of thousands of genes is possible, and comparisons between ...
Al-Ghazi, Yves, Arioli, Tony, Claverie, Michel, Dennis, Elizabeth, Derycker, Ruud, Forestier-Chiron, Nelly, Giband, Marc, Jacobs, John, Jean, Janine, Lacape, Jean-Marc, Llewellyn, Danny, Viot, Christopher   +11 more
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