Results 151 to 160 of about 46,677 (295)

Dysregulated protocadherin-pathway activity as an intrinsic defect in induced pluripotent stem cell-derived cortical interneurons from subjects with schizophrenia. [PDF]

, 2019
We generated cortical interneurons (cINs) from induced pluripotent stem cells derived from 14 healthy controls and 14 subjects with schizophrenia. Both healthy control cINs and schizophrenia cINs were authentic, fired spontaneously, received functional ...
Apud, Jose, Berman, Karen F, Bin Kim, Woong, Cho, Jun-Hyeong, Chung, Sangmi, Cohen, Bruce M, Cote, Sarah E, Coyle, Joseph T, Eggan, Kevin C, Eisenberg, Leonard M, Fukuda, Emi, Ghosh, Sulagna, Hirayama, Teruyoshi, Huang, Weihua, Kim, Hae-Young, Lanz, Thomas A, McPhie, Donna L, Moghadam, Alexander A, Nguyen, Christine, Ni, Peiyan, Noh, Haneul, Noyes, Elizabeth, Ongur, Dost, Park, James M, Park, Joshua J, Parsons, Teagan, Perlis, Roy H, Rapoport, Judith L, Shao, Zhicheng, Stanton, Patric K, Straub, Richard E, Weinberger, Daniel R, Xi, Hualin Simon, Yagi, Takeshi, Yin, Changhong, Zhao, Joyce, Zheng, Kelvin   +36 more
core   +1 more source

Identifying Thyroid Carcinoma-Related Genes by Integrating GWAS and eQTL Data [PDF]

, 2021
Fei Shen, Xiao‐Xiong Gan, Ruiying Zhong, Jianhua Feng, Zhen Chen, Mengli Guo, Yayi Li, Zhao‐Feng Wu, Wen-song Cai, Bo Xu   +9 more
openalex   +1 more source

M2 Macrophages are Major Mediators of Germline Risk of Endometriosis and Explain Pleiotropy With Comorbid Traits

Advanced Science, Volume 12, Issue 41, November 6, 2025.
Genes associated with endometriosis risk are highly expressed in M2 macrophages, particularly ligands IL1A and IL1B. Endometrial‐type epithelium and stroma are likely recipients of these ligands. While IL1B treatment disturbs epithelial organization, blockage of the signaling results in a dose‐dependent decrease in spontanesous and evoked pain, reduces
Soledad Ochoa, Fernanda S. Rasquel‐Oliveira, Brett McKinnon, Marcela Haro, Sugarniya Subramaniam, Pak Yu, Simon Coetzee, Michael S. Anglesio, Kelly N. Wright, Raanan Meyer, Anne E. Porter, Caroline E. Gargett, Sally Mortlock, Grant W. Montgomery, Michael S. Rogers, Kate Lawrenson   +15 more
wiley   +1 more source

Massively parallel reporter assays combined with cell-type specific eQTL informed multiple melanoma loci and identified a pleiotropic function of HIV-1 restriction gene,MX2, in melanoma promotion [PDF]

, 2019
Jiyeon Choi, Tongwu Zhang, Andrew Vu, Julien Ablain, Matthew Makowski, Leandro M. Colli, Mai Xu, Harriet Rothschild, Cathrin Gräwe, Michael A. Kovacs, Myriam Brossard, John Taylor, Bogdan Paşaniuc, Raj Chari, Stephen J. Chanock, Clive Hoggart, Florence Démenais, Jennifer H. Barrett, Matthew H. Law, Mark M. Iles, Kai Yu, Michiel Vermeulen, Leonard I. Zon, Kevin M. Brown   +23 more
openalex   +1 more source

Trans-eQTLs of the CYP3A4 and CYP3A5 associated with tacrolimus trough blood concentration in Chinese renal transplant patients

, 2021
Huijie Lu, Haixia Jiang, Siyao Yang, Chengcheng Li, Chuanjiang Li, Ruifan Shao, Pai Zhang, Daoyi Wang, Zhiwei Liu, Huana Qi, Yinuan Cai, Wenbin Xu, Xiaojie Bao, Hailan Wang, Liang Li   +14 more
openalex   +1 more source

Transcriptome‐Wide Association Uncovers LncRNAs Controlling Seed Weight in Soybean

Advanced Science, Volume 12, Issue 41, November 6, 2025.
This study employs transcriptome‐wide association studies (TWAS) to identify 201 long non‐coding RNAs (lncRNAs) associated with seed weight. Expression quantitative trait locus (eQTL) analysis reveals dynamic and static regulatory variants controlling lncRNA expression across development.
Xiang Wang, Xinyu Jiang, Xiaobo Yuan, Zhipeng Zhou, Zhenwei Zhao, Longfei Wang, Wu Jiao, Wenxue Ye, Qingxin Song   +8 more
wiley   +1 more source

SCRIPT: Predicting Single‐Cell Long‐Range Cis‐Regulation Based on Pretrained Graph Attention Networks

Advanced Science, Volume 12, Issue 41, November 6, 2025.
SCRIPT is a novel method inferring single‐cell cis‐regulatory relationships (CRRs) from transcriptomic and chromatin accessibility data. SCRIPT incorporates two key innovations: graph causal attention networks supported by empirical CRR evidence, and representation learning enhanced through pretraining on atlas‐scale single‐cell data.
Yu Zhang, Baole Wen, Yifeng Jiao, Yuchen Liu, Xin Guo, Yushuai Wu, Jiyang Li, Limei Han, Yinghui Xu, Xin Gao, Yuan Qi, Yuan Cheng, Ying He, Weidong Tian   +13 more
wiley   +1 more source

Allele‐Specific Regulation of PAXIP1‐AS1 by SMC3/CEBPB at rs112651172 in Psychiatric Disorders Drives Synaptic and Behavioral Dysfunctions in Mice

Advanced Science, Volume 12, Issue 44, November 27, 2025.
This study identifies a functional noncoding variant, rs112651172 (C/G), that drives allele‐specific expression of PAXIP1‐AS1 in monozygotic twin pairs discordant for schizophrenia and bipolar disorder. The risk G allele enhances CEBPB binding, leading to lncRNA upregulation, CNTNAP3 derepression, and synaptic and behavioral deficits in mice.
Chaoying Ni, He Chen, Qiaqi Chen, Yangyang Liao, Yunqian Wang, Linyan Ye, Xiaohui Wu, Hongyu Ni, Tingyun Jiang, Shufen Li, Qiong Yang, Hong Xue, Zhongju Wang, Feng Yi, Cunyou Zhao   +14 more
wiley   +1 more source

PICALO: principal interaction component analysis for the identification of discrete technical, cell-type, and environmental factors that mediate eQTLs

Genome Biology
Expression quantitative trait loci (eQTL) offer insights into the regulatory mechanisms of trait-associated variants, but their effects often rely on contexts that are unknown or unmeasured.
Martijn Vochteloo, Patrick Deelen, Britt Vink, BIOS Consortium, Ellen A. Tsai, Heiko Runz, Sergio Andreu-Sánchez, Jingyuan Fu, Alexandra Zhernakova, Harm-Jan Westra, Lude Franke   +10 more
doaj   +1 more source

Marker Metabolite‐Based Multi‐Omics Analysis Identifies New Loci Controlling Thousand Seed Weight in Brassica Napus

Advanced Science, Volume 12, Issue 42, November 13, 2025.
Marker metabolite‐based multi‐omics (genome, transcriptome, and metabolome) analysis is conducted firstly to unravel the genetic basis of thousand seed weight (TSW) in Brassica napus. The released metabolite‐QTL‐gene network represents a valuable genetic resource, and the newly validated BnaTGA6 is a promising target for the improvement of TSW in ...
Long Li, Zhitao Tian, Xiaowei Wu, Zengdong Tan, Xu Han, Yuyan Xiang, Jie Chen, Hu Zhao, Wei Chen, Liang Guo, Xuan Yao   +10 more
wiley   +1 more source