Results 181 to 190 of about 46,677 (295)

Integrative Single-Cell Analysis: Dissecting CD8+ Memory Cell Roles in LUAD and COVID-19 via eQTLs and Mendelian Randomization [PDF]

, 2023
Jintao Wu, Xiaocheng Mao, Xiaohua Liu, Junying Mao, Xianxin Yang, Xiangwu zhou, Lu Tianzhu, Yulong Ji, Li Zhao, Huijuan Xu   +9 more
openalex   +1 more source

Sex‐ and APOE Genotype–Dependent Pain Susceptibility and Alzheimer's Risk Mediated by the Lipid Metabolism Enzyme LPCAT2

Aging Cell, Volume 24, Issue 11, November 2025.
We aimed to uncover the molecular mechanisms linking age‐related pain susceptibility with cognitive decline in Alzheimer's disease (AD). By integrating transcriptomic, human AD brain, genomic, and Mendelian randomization analyses, we identified the lipid‐modifying enzyme LPCAT2 as a sex‐ and APOE genotype–dependent causal mediator of both heightened ...
Rai‐Hua Lai, Ren‐Hua Chung, Wan‐Yu Pai, Yi‐Chung Chen, Ka‐Hei Lam, Cheng‐Nong Lai, Jyh‐Lyh Juang   +6 more
wiley   +1 more source

Characterizing the Relationship between Expression Quantitative Trait Loci (eQTLs), DNA Methylation Quantitative Trait Loci (mQTLs), and Breast Cancer Risk Variants [PDF]

Peh Joo Ho, Alexis Jiaying Khng, Benita Kiat Tee Tan, Chiea Chuen Khor, Ern Yu Tan, Geok Hoon Lim, Jian‐Min Yuan, Su‐Ming Tan, Xuling Chang, Veronique Kiak Mien Tan, Xueling Sim, Rajkumar Dorajoo, Woon‐Puay Koh, Mikael Hartman, Jingmei Li   +14 more
openalex   +1 more source

eMAGMA: An eQTL-informed method to identify risk genes using genome-wide association study summary statistics [PDF]

, 2019
Zachary Gerring, Angela Mina-Vargas, Eske M. Derks   +2 more
openalex   +1 more source

Genotype‐by‐sex interaction analyses for alcohol use disorder across biobanks

Alcohol, Clinical and Experimental Research, Volume 49, Issue 11, Page 2485-2493, November 2025.
Alcohol use disorder (AUD) differs by sex in prevalence and clinical features, yet genetic studies on these differences are limited. Using genome‐wide genotype‐by‐sex interaction analyses in over 1 million participants from the Million Veteran Program and UK Biobank, we identified four significant loci with sex‐specific effects on AUD risk.
Hang Zhou, Lu Wang, Zhongzheng Mao, P. J. Michael Deans, Rachel L. Kember, Qingyu Chen, Yasmin Zakiniaeiz, Robert Kohler, MacKenzie R. Peltier, Terril L. Verplaetse, VA Million Veteran Program, Marc N. Potenza, Kristen J. Brennand, Amy C. Justice, Henry R. Kranzler, Joel Gelernter, Sherry A. McKee, Sumitra Muralidhar, Jennifer Moser, Jennifer E. Deen, Philip S. Tsao, Sumitra Muralidhar, J. Michael Gaziano, Elizabeth Hauser, Amy Kilbourne, Michael Matheny, Dave Oslin, Deepak Voora, J. Michael Gaziano, Philip S. Tsao, Jessica V. Brewer, Mary T. Brophy, Mary T. Brophy, Lori Churby, Scott L. DuVall, Saiju Pyarajan, Robert Ringer, Luis E. Selva, Shahpoor (Alex) Shayan, Brady Stephens, Stacey B. Whitbourne, Themistocles L. Assimes, Adriana Hung, Henry Kranzler   +43 more
wiley   +1 more source

Review for "Integrating GWAS and eQTL to predict genes and pathways for non‐syndromic cleft lip with or without palate"

, 2020
Renato Assis Machado
openalex   +1 more source

Genetic Crosstalk Between Type 1 Diabetes and Sjögren's Syndrome: A Systematic Exploration of Risk Genes and Common Pathways

Journal of Cellular and Molecular Medicine, Volume 29, Issue 22, November 2025.
ABSTRACT Sjögren's Syndrome (SS) and Type 1 Diabetes (T1D) are autoimmune disorders that can co‐occur in patients, leading to complex clinical presentations. Despite observational evidence of their co‐occurrence, the underlying genetic mechanisms remain poorly understood.
Aamir Fahira, Kai Zhuang, Xuemin Jian, Syed Mansoor Jan, Yong Liu, Jianbo Sun, Yongyong Shi, Zunnan Huang   +7 more
wiley   +1 more source

Identification of Expression Quantitative Trait Loci (eQTL) for Adipose-Specific Regulatory Mechanisms in Hanwoo (Korean Cattle). [PDF]

Animals (Basel)
Lee J, Jeong T, Park W, Jang S, Lee PY, Lim D.   +5 more
europepmc   +1 more source

Cell-type-specific cis-eQTLs in pancreatic cell types identify novel risk genes for type 2 diabetes

Xiaocao Miao, Hui Li, Qing Li, Lei Zhu, Yanqiu Yu, Jianguang Ji, Tao Chen, Zhigang Zhang, Dong‐Xue Li   +8 more
openalex   +1 more source

Colocalization of GWAS and eQTL Signals Detects Target Genes

bioRxiv, 2016
F. Hormozdiari, M. van de Bunt, A. Segrè, Xiao Li, J. W. Joo, Michael Bilow, J. Sul, S. Sankararaman, B. Pasaniuc, E. Eskin   +9 more
semanticscholar   +1 more source