DNA methylation modulated genetic variant effect on gene transcriptional regulation
Genome Biology, 2023 Background Expression quantitative trait locus (eQTL) analysis has emerged as an important tool in elucidating the link between genetic variants and gene expression, thereby bridging the gap between risk SNPs and associated diseases.
Yong Zeng +9 more
doaj +1 more source
Expression quantitative trait loci in sheep liver and muscle contribute to variations in meat traits
Genetics Selection Evolution, 2021 Background Variants that regulate transcription, such as expression quantitative trait loci (eQTL), have shown enrichment in genome-wide association studies (GWAS) for mammalian complex traits. However, no study has reported eQTL in sheep, although it is
Zehu Yuan +13 more
doaj +1 more source
ForestPMPlot: A Flexible Tool for Visualizing Heterogeneity Between Studies in Meta-analysis. [PDF]
, 2016 Meta-analysis has become a popular tool for genetic association studies to combine different genetic studies. A key challenge in meta-analysis is heterogeneity, or the differences in effect sizes between studies.
Eskin, Eleazar +5 more
core +3 more sources
Optimizing expression quantitative trait locus mapping workflows for single-cell studies
Genome Biology, 2021 Background Single-cell RNA sequencing (scRNA-seq) has enabled the unbiased, high-throughput quantification of gene expression specific to cell types and states.
Anna S. E. Cuomo +5 more
doaj +1 more source
Using genomic annotations increases statistical power to detect eGenes. [PDF]
, 2016 MotivationExpression quantitative trait loci (eQTLs) are genetic variants that affect gene expression. In eQTL studies, one important task is to find eGenes or genes whose expressions are associated with at least one eQTL. The standard statistical method
Duong, Dat +6 more
core +1 more source
Joint analysis of SNP and gene expression data in genetic association studies of complex diseases [PDF]
, 2014 Genetic association studies have been a popular approach for assessing the association between common Single Nucleotide Polymorphisms (SNPs) and complex diseases.
Huang, Yen-Tsung +2 more
core +1 more source
Expression quantitative trait loci (eQTL) mapping in Puerto Rican children. [PDF]
PLoS ONE, 2015 Expression quantitative trait loci (eQTL) have been identified using tissue or cell samples from diverse human populations, thus enhancing our understanding of regulation of gene expression.
Wei Chen +8 more
doaj +1 more source
Molecular Relationships between Bronchial Asthma and Hypertension as Comorbid Diseases
Journal of Integrative Bioinformatics, 2018 Comorbidity, a co-incidence of several disorders in an individual, is a common phenomenon. Their development is governed by multiple factors, including genetic variation.
Bragina Elena Yu. +14 more
doaj +1 more source
Frontiers in Genetics, 2021 Motivation: Genome-wide association studies (GWAS) have achieved remarkable success in identifying SNP-trait associations in the last decade. However, it is challenging to identify the mechanisms that connect the genetic variants with complex traits as ...
Yi Yang, Kar-Fu Yeung, Jin Liu
doaj +1 more source
Genome-wide linkage analysis of global gene expression in loin muscle tissue identifies candidate genes in pigs. [PDF]
PLoS ONE, 2011 BACKGROUND: Nearly 6,000 QTL have been reported for 588 different traits in pigs, more than in any other livestock species. However, this effort has translated into only a few confirmed causative variants.
Juan Pedro Steibel +10 more
doaj +1 more source