Results 11 to 20 of about 48,393 (270)

Matrix eQTL: ultra fast eQTL analysis via large matrix operations [PDF]

Bioinformatics, 2011
MOTIVATION Expression quantitative trait loci (eQTL) analysis links variations in gene expression levels to genotypes. For modern datasets, eQTL analysis is a computationally intensive task as it involves testing for association of billions of transcript-
A. Shabalin
semanticscholar   +10 more sources

Large eQTL meta-analysis reveals differing patterns between cerebral cortical and cerebellar brain regions

Scientific Data, 2020
The availability of high-quality RNA-sequencing and genotyping data of post-mortem brain collections from consortia such as CommonMind Consortium (CMC) and the Accelerating Medicines Partnership for Alzheimer’s Disease (AMP-AD) Consortium enable the ...
Solveig K Sieberts, Steven G Younkin, Minerva M Carrasquillo   +2 more
exaly   +2 more sources

Transcription factor regulation of eQTL activity across individuals and tissues.

PLoS Genetics, 2022
Tens of thousands of genetic variants associated with gene expression (cis-eQTLs) have been discovered in the human population. These eQTLs are active in various tissues and contexts, but the molecular mechanisms of eQTL variability are poorly understood,
Elise D Flynn, Athena L Tsu, Silva Kasela, Sarah Kim-Hellmuth, Francois Aguet, Kristin G Ardlie, Harmen J Bussemaker, Pejman Mohammadi, Tuuli Lappalainen   +8 more
doaj   +2 more sources

Contribution of trans regulatory eQTL to cryptic genetic variation in C. elegans

BMC Genomics, 2017
Background Cryptic genetic variation (CGV) is the hidden genetic variation that can be unlocked by perturbing normal conditions. CGV can drive the emergence of novel complex phenotypes through changes in gene expression.
Basten L. Snoek, Mark G. Sterken, Roel P. J. Bevers, Rita J. M. Volkers, Arjen van’t Hof, Rachel Brenchley, Joost A. G. Riksen, Andrew Cossins, Jan E. Kammenga   +8 more
doaj   +2 more sources

Landscape of Conditional eQTL in Dorsolateral Prefrontal Cortex and Co-localization with Schizophrenia GWAS

American Journal of Human Genetics, 2018
Causal genes and variants within genome-wide association study (GWAS) loci can be identified by integrating GWAS statistics with expression quantitative trait loci (eQTL) and determining which variants underlie both GWAS and eQTL signals.
Laura M Huckins, James Boocock, Laura G Sloofman   +2 more
exaly   +2 more sources

An eQTL Landscape of Kidney Tissue in Human Nephrotic Syndrome

American Journal of Human Genetics, 2018
Expression quantitative trait loci (eQTL) studies illuminate the genetics of gene expression and, in disease research, can be particularly illuminating when using the tissues directly impacted by the condition.
Rajasree Menon, Edgar A Otto, Viji Nair
exaly   +2 more sources

eQTL epistasis – challenges and computational approaches [PDF]

Frontiers in Genetics, 2013
The determination of eQTL epistasis - a form of functional interaction between genetic loci that affect gene expression - is an important step towards the thorough understanding of gene regulation.
Yang eHuang, Stefan eWuchty, Teresa M Przytycka   +2 more
doaj   +3 more sources

Single-cell eQTL models reveal dynamic T cell state dependence of disease loci

Nature, 2022
Aparna Nathan, Samira Asgari, Kazuyoshi Ishigaki   +2 more
exaly   +2 more sources

Integration of summary data from GWAS and eQTL studies predicts complex trait gene targets

Nature Genetics, 2016
Zhihong Zhu, Futao Zhang, Han Hu
exaly   +2 more sources

Data-driven assessment of eQTL mapping methods [PDF]

BMC Genomics, 2010
Background The analysis of expression quantitative trait loci (eQTL) is a potentially powerful way to detect transcriptional regulatory relationships at the genomic scale.
Schughart Klaus, Alberts Rudi, Michaelson Jacob J, Beyer Andreas   +3 more
doaj   +5 more sources